Development and release characterization of hyaluronan-doxycycline gels based on metal coordination

Journal of Controlled Release

Volumn 76, Issue 3, 2001, Pages 337-347

  Miyazaki, Tamaki ^a   Yomota, Chikako ^a   Okada, Satoshi ^a  

^a NATIONAL INSTITUTE OF HEALTH SCIENCES   (Japan)

Author keywords

Coordinate bond; Doxycycline; Gel; Hyaluronan; Release test

Indexed keywords

CARBOXYL GROUP; DIKETONE; DOXYCYCLINE; HYALURONIC ACID; METAL ION; PHENOL DERIVATIVE; WATER;

AQUEOUS SOLUTION; ARTICLE; CHELATION; CROSS LINKING; DIFFUSION; DRUG MIXTURE; DRUG RELEASE; DRUG STRUCTURE; ELECTRICITY; GEL; HYDROGEL; MOLECULAR WEIGHT; PRIORITY JOURNAL; WATER CONTENT;

ALGORITHMS; ANTI-BACTERIAL AGENTS; CATIONS, DIVALENT; CROSS-LINKING REAGENTS; DOXYCYCLINE; GELS; HYALURONIC ACID; METALS; MOLECULAR WEIGHT;

EID: 0035914231     PISSN: 01683659     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0168-3659(01)00453-9     Document Type: Article

References (37)

1. The effects of thickness and hardness of the coating film on the drug release rate of theophylline granules coated with chitosan-sodium tripolyphosphate complex
2. Therapeutic applications of implantable drug delivery systems
3. Characteristics of polyion complexes of chitosan with sodium alginate and sodium polyacrylate
4. Enhancement of dissolution rates of several drugs by low-molecular chitosan and alginate
5. Effect of interpolymer complex formation on bioadhesive property and drug release phenomenon of compressed tablet consisting of chitosan and sodium hyaluronate
6. Inflammation responsive degradation of crosslinked hyaluronic acid gels
7. Effects of viscous hyaluronate-sodium solutions on the nasal absorption of vasopressin and an analogue
8. Sustained release effect of the direct compressed tablet based on chitosan and sodium alginate
9. Development and mechanical characterization of bioadhesive semi-solid, polymeric systems containing tetracycline for the treatment of periodontal diseases
10. A novel in situ-forming ophthalmic drug delivery system from alginates undergoing gelation in the eye
11. Hyaluronate-alginate gel as a novel biomaterial: Mechanical properties and formation mechanism
12. In vitro release kinetics of gentamycin from a sodium hyaluronated gel delivery system suitable for the treatment of peripheral vestibular disease
13. Targeting of tumor necrosis factor to tumor by use of dextran and metal coordination
14. Simple mixing of IFN with a polysaccharide having high liver affinity enables IFN to target to the liver
15. Interaction between sodium hyaluronate and tetracyclines
16. Inhibition of tumor growth in vivo by hyaluronan oligomers
17. Mechanisms of hyaluronan-induced up-regulation of ICAM-1 and VCAM-1 expression by murine kidney tubular epithelial cells: Hyaluronan triggers cell adhesion molecule expression through a mechanism involving activation of nuclear factor-κB and activating protein-1
18. Effects of hyaluronan on periosteal grafts for large full-thickness defects in rabbit articular cartilage
19. Induction and regulation of macrophage metalloelastase by hyaluronan fragments in mouse macrophages
20. Hyaluronan stimulates tumor cell migration by modulating the fibrin fiber architecture
21. Effects of hyaluronan fragments on synovial fibroblasts in rheumatoid arthritis
22. Oligosaccharides of hyaluronan are potent activators of dendritic cells
23. A modified uronic acid carbazole reaction
24. Acidity constants of the tetracycline antibiotics
25. Hydrogenolysis studies in the tetracycline series: 6-deoxytetracyclines
26. pH-partition behavior of tetracyclines
27. Polyelectrolyte properties of sodium hyaluronate. 2. Potentiometric titration of hyaluronic acid
28. Interaction between hyaluronan and cationic surfactants
29. Phase behavior of systems of cationic surfactant and anionic polyelectrolyte: Influence of surfactant chain length and polyelectrolyte molecular weight
30. Gel formation in aqueous systems of a polyanion and an oppositely charged surfactant
31. Amphiphile arzneistoffe
32. Degradation of hyaluronic acid at the metal surface
33. The influence of additives on the cloud point, disintegration and dissolution of hydroxypropylmethylcellulose gels and matrix tablets
34. Swelling behavior of hyaluronic acid gels
35. Studies on novel phosphatidylcholine-modified acrylamide-based hydrogels
36. Preparation and characterization of hyaluronate-hydroxyethyl acrylate blend hydrogel for controlled release device