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0041863458
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note
-
TBME was chosen as solvent for the DKR due to the high enantiomeric ratio (E > 200) obtained with the PS-C lipase for our model substrate in this solvent.
-
-
-
-
37
-
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0041863459
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In the case of benzylic acetates, the elimination leads to a highly conjugated double bond
-
In the case of benzylic acetates, the elimination leads to a highly conjugated double bond.
-
-
-
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38
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0042865425
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note
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2O).
-
-
-
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39
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0042865426
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note
-
The kinetic resolution of compound 1a with the recovered enzyme gave the same E value. ee = enantiomeric excess of substrate (S) or product (P) and E = enantiomeric ratio (formula presented)
-
-
-
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40
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0037664931
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0028106548
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Kinetic resolution by acetate hydrolysis of methyl esters similar to compounds 2 having a methyl group in the α-position is known: Akita, H.; Chen, C. Y.; Nagumo, S. Tetrahedron: Asymmetry 1994, 5, 1207-1210.
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45
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0031562040
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For recent catalytic aldol reactions with preformed nonsubstituted silyl enol ethers giving high ee's, see: (a) Singer, R. A.; Carreira, E. M. Tetrahedron. Lett. 1997, 38, 927-930.
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