Cytotoxic responses to aromatic ring and configurational variations in α-conidendrin, podophyllotoxin, and sikkimotoxin derivatives

Journal of Medicinal Chemistry

Volumn 44, Issue 2, 2001, Pages 180-185

  Dantzig, A ^a   LaLonde, R T ^b   Ramdayal, F ^b   Shepard, R L ^a   Yanai, K ^a,c   Zhang, M ^b  

^a ELI LILLY AND COMPANY   (United States)

^b STATE UNIVERSITY OF NEW YORK   (United States)

^c Nippon Paper Industries Co Ltd   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

9 DEOXYPODOPHYLLOL; 9 DEOXYSIKKIMOL; ALPHA CONIDENDRIN; DIMETHYL ALPHA CONIDENDRYL; ETOPOSIDE; PODOPHYLLOTOXIN DERIVATIVE; SIKKIMOTOXIN DERIVATIVE; TETRALIN DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CELL LINE; CONTROLLED STUDY; CYTOTOXICITY; DEHYDRATION; DRUG ACTIVITY; DRUG SCREENING; DRUG SENSITIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; LEUKEMIA CELL; MULTIDRUG RESISTANCE; STRUCTURE ACTIVITY RELATION;

ANTINEOPLASTIC AGENTS; ATP-BINDING CASSETTE TRANSPORTERS; DRUG RESISTANCE, MULTIPLE; DRUG RESISTANCE, NEOPLASM; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; LIGNANS; MAGNETIC RESONANCE SPECTROSCOPY; MASS SPECTROMETRY; MOLECULAR CONFORMATION; MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS; P-GLYCOPROTEIN; PODOPHYLLOTOXIN; STRUCTURE-ACTIVITY RELATIONSHIP; TETRAHYDRONAPHTHALENES; TUMOR CELLS, CULTURED;

EID: 0035905866     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm990563p     Document Type: Article

References (16)

1. Podophyllotoxin
2. In vitro propagation of P. peltatum
3. Nonenolizable podophyllotoxin derivatives
4. Antitumor agents. 124. New 4β-substituted aniline derivatives of 6,7-O,O-demethylene-4′-O-demethylpodophyllotoxin and related compounds as potent inhibitors of human DNA topoisomerase II
5. E-ring desoxyanalogues of etoposide
6. Directed DDQ-promoted benzylic oxygenations of tetrahydronaphthalenes
7. The naturally occurring lignans
8. The naturally occurring lignans
9. Application of tosylate reductions and molecular rotations to the stereochemistry of lignans
10. Antitumor agents. I. DNA topoisomerase II inhibitory activity and the structural relationship of podophyllotoxin derivatives as antitumor agents
11. Zur structure des sikkimotoxins II. Partial-synthese der 6,7-dimethoxy-analogen von podophyllotoxin
12. The asymmetric synthesis of aryltetralin lignans: (-)-Isolariciresinol dimethyl ether and (-)-deoxysikkimotoxin
13. Altered surface membrane glycoprotiens in Vinca alkaloid-resistant human leukemic lymphoblast
14. Rapid colorimetric assay for cell growth and survival. Modifications to the tetrazolium dye procedure giving improved sensitivity and reliability
15. Reversal of P-glycoprotein-mediated multidrug resistance by a potent cyclopropyldibenzosuberan modulator, LY335979