Catalytic antibody route to the naturally occurring epothilones: Total synthesis of epothilones A-F

Chemistry - A European Journal

Volumn 7, Issue 8, 2001, Pages 1691-1702

  Sinha, Subhash C ^a   Sun, Jian ^a   Miller, Gregory P ^a   Wartmann, Markus ^b   Lerner, Richard A ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

^b NOVARTIS PHARMA AG   (Switzerland)

Author keywords

Antibodies; Antitumor agents; Chiral resolution; Epothilones; Retro aldol reactions

Indexed keywords

CATALYSIS; CATALYSTS; SYNTHESIS (CHEMICAL);

ALDOL COMPOUNDS;

ANTIBODIES;

ANTINEOPLASTIC AGENT; ANTINEOPLASTIC ANTIBIOTIC; CATALYTIC ANTIBODY; EPOTHILON D; EPOTHILONE A; EPOTHILONE B; EPOTHILONE C; EPOTHILONE D; EPOTHILONE DERIVATIVE; EPOTHILONE E; EPOTHILONE F; EPOXIDE; FRUCTOSE BISPHOSPHATE ALDOLASE; HAPTEN; MACROLIDE; THIAZOLE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CATALYSIS; CHEMICAL STRUCTURE; DRUG SYNTHESIS; ENANTIOMER; MYXOCOCCALES; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; REACTION ANALYSIS; STEREOISOMERISM;

ANTI-BACTERIAL AGENTS; ANTIBIOTICS, ANTINEOPLASTIC; ANTIBODIES, CATALYTIC; ANTINEOPLASTIC AGENTS; EPOTHILONES; EPOXY COMPOUNDS; FRUCTOSE-BISPHOSPHATE ALDOLASE; HAPTENS; MACROLIDES; MAGNETIC RESONANCE SPECTROSCOPY; MOLECULAR STRUCTURE; MYXOCOCCALES; STEREOISOMERISM; THIAZOLES;

EID: 0035901666     PISSN: 09476539     EISSN: None     Source Type: Journal    
DOI: 10.1002/1521-3765(20010417)7:8<1691::AID-CHEM16910>3.0.CO;2-9     Document Type: Article

References (5)

1. a) A. Tramontano, K. D. Janda, R. A. Lerner, Science 1986, 234, 1566;
2. b) S. J. Pollack, J. W. Jacobs, P. G. Schultz, Science 1986, 234, 1570.
3. a) P. G. Schultz, R. A. Lerner, Science 1995, 269, 1835;
4. b) E. Keinan, R. A. Lerner, Isr. J. Chem. 1996, 36, 113;
5. c) J.-L. Raymond, Top. Curr. Chem. 1999, 200, 59.