Expression of microbial virulence proteins in Saccharomyces cerevisiae models mammalian infection

EMBO Journal

Volumn 20, Issue 8, 2001, Pages 1840-1849

  Lesser, C F ^a   Miller, S I ^a  

^a UNIVERSITY OF WASHINGTON   (United States)

Author keywords

Actin cytoskeleton; Cell cycle; Salmonella; Type III secretion; Yersinia

Indexed keywords

ACTIN; BACTERIAL PROTEIN; GUANOSINE TRIPHOSPHATASE ACTIVATING PROTEIN;

ARTICLE; BACTERIAL INFECTION; BACTERIAL VIRULENCE; CELL CYCLE; CELL MEMBRANE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; CYTOSKELETON; DEPOLYMERIZATION; EUKARYOTIC CELL; NONHUMAN; PATHOGENESIS; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; SACCHAROMYCES CEREVISIAE; SALMONELLA; YEAST; YERSINIA;

ACTINS; ADHESINS, BACTERIAL; BACTERIAL OUTER MEMBRANE PROTEINS; BACTERIAL PROTEINS; BACTERIOLOGICAL TECHNIQUES; CELL CYCLE; CELL DIVISION; CELL POLARITY; CYTOSKELETON; GTPASE-ACTIVATING PROTEINS; RECOMBINANT PROTEINS; SACCHAROMYCES CEREVISIAE; SALMONELLA; VIRULENCE; YERSINIA ENTEROCOLITICA;

BACTERIA (MICROORGANISMS); EUKARYOTA; MAMMALIA; SACCHAROMYCES CEREVISIAE; SALMONELLA; YERSINIA;

EID: 0035901559     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/20.8.1840     Document Type: Article

References (37)

1. Isoform-specific complementation of the yeast sac6 null mutation by human fimbrin
2. High rates of actin filament turnover in budding yeast and roles for actin in establishment and maintenance of cell polarity revealed using the actin inhibitor latrunculin-A
3. The yeast V159N actin mutant reveals roles for actin dynamics in vivo
4. The RhoGAP activity of the Yersinia pseudotuberculosis cytotoxin YopE is required for antiphagocytic function and virulence
5. Diversion of cytoskeletal processes by Shigella during invasion of epithelial cells
6. Role of small G proteins in yeast cell polarization and wall biosynthesis
7. Molecular and cell biology aspects of plague
8. The virulence plasmid of Yersinia, an antihost genome
9. Penetration of protein toxins into cells
10. Human genetic diseases: A cross-talk between man and yeast
11. Morphological and cytoskeletal changes in epithelial cells occur immediately upon interaction with Salmonella typhimurium grown under low-oxygen conditions
12. Type III secretion machines: Bacterial devices for protein delivery into host cells
13. Striking a balance: Modulation of the actin cytoskeleton by Salmonella
14. The Yersinia YpkA Ser/Thr kinase is translocated and subsequently targeted to the inner surface of the HeLa cell plasma membrane
15. Type III protein secretion systems in bacterial pathogens of animals and plants
16. Microbial determinations by flow cytometry
17. A cell cycle checkpoint monitors cell morphogenesis in budding yeast
18. A morphogenesis checkpoint monitors the actin cytoskeleton in yeast
19. Cell-surface-bound Yersinia translocate the protein tyrosine phosphatase YopH by a polarized mechanism into the target cell
20. The cytolethal distending toxin family
21. Fluorescence microscopy methods for yeast
22. Polarization of cell growth in yeast. I. Establishment and maintenance of polarity states
23. The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors
24. The cytotoxic protein YopE of Yersinia obstructs the primary host defence
25. Intracellular targeting of the Yersinia YopE cytotoxin in mammalian cells induces actin microfilament disruption
26. Microinjection of the Yersinia YopE cytotoxin in mammalian cells induces actin microfilament disruption
27. Target cell contact triggers expression and polarized transfer of Yersinia YopE cytotoxin into mammalian cells
28. Nonspecific modification of cellular immunity by Yersinia enterocolitica
29. A system of shuttle vectors and yeast host strains designed for efficient manipulation of DNA in Saccharomyces cerevisiae
30. Targeting of the Yersinia pestis YopM protein into HeLa cells and intracellular trafficking to the nucleus
31. Type HI secretion system in Chlamydia species: Identified members and candidates
32. GAP activity of the Yersinia YopE cytotoxin specifically targets the Rho pathway: A mechanism for disruption of actin microfilament structure
33. Growth site localization of Rho 1 small GTP-binding protein and its involvement in bud formation in Saccharomyces cerevisiae
34. Suppression of T and B lymphocyte activation by a Yersinia pseudotuberculosis virulence factor, yopH
35. The BvgAS virulence control system regulates type III secretion in Bordetella bronchiseptica
36. Role of the S. Typhimurium actin-binding protein SipA in bacterial internalization