Drug-induced alterations in tumour perfusion yield increases in tumour cell radiosensitivity

British Journal of Cancer

Volumn 85, Issue 10, 2001, Pages 1577-1584

  Bennewith, K L ^a   Durand, R E ^a  

^a BRITISH COLUMBIA CANCER RESEARCH CENTRE   (Canada)

Author keywords

Diltiazem; Hypoxia; Pentoxifylline; Radiosensitivity; Tumour perfusion

Indexed keywords

DILTIAZEM; PENTOXIFYLLINE; RUBIDIUM CHLORIDE;

ANIMAL MODEL; ARTICLE; BLOOD FLOW; CELL SELECTION; COMPARATIVE STUDY; CONTROLLED STUDY; FLOW KINETICS; HUMAN; HUMAN CELL; HYPOXIC CELL; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; OXYGENATION; PRIORITY JOURNAL; RADIOSENSITIVITY; TUMOR CELL; TUMOR XENOGRAFT;

ANIMALS; CALCIUM CHANNEL BLOCKERS; DILTIAZEM; DOSE-RESPONSE RELATIONSHIP, DRUG; FLOW CYTOMETRY; HEMATOLOGIC AGENTS; HUMANS; KINETICS; MICE; NEOPLASMS; PENTOXIFYLLINE; PERFUSION; RADIATION TOLERANCE; REGIONAL BLOOD FLOW; RUBIDIUM RADIOISOTOPES; TUMOR CELLS, CULTURED; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 0035900817     PISSN: 00070920     EISSN: None     Source Type: Journal    
DOI: 10.1054/bjoc.2001.2123     Document Type: Article

References (36)

1. Diltiazem hydrochloride
2. Pentoxifylline
3. Effect of pentoxifylline on the flow of polymorphonuclear leukocytes through a model capillary
4. Cell selection from a murine tumor using the fluorescent probe Hoechst 33342
5. Acute hypoxia in tumors: Implications for modifiers of radiation effects
6. Use of a cell sorter for assays of cell clonogenicity
7. Cell kinetics and repopulation during multifraction irradiation of spheroids: Implications for clinical radiotherapy
8. The influence of microenvironmental factors during cancer therapy
9. Modulation of tumor hypoxia by conventional chemotherapeutic agents
10. Contribution of transient blood flow to tumour hypoxia in mice
11. Intermittent tumour blood flow: Implications for therapy
12. The effect of pentoxifylline on the flow properties of human blood
13. Studies on a new human cell line (SiHa) derived from carcinoma of uterus. L Its establishment and morphology
14. Calcium channels and calcium antagonists
15. Studies on the exchange of fluids between host and tumor. II. The blood flow of hepatomas and other tumors in rats and mice
16. Effect of hypoxia on erythrocyte deformability in different species
17. Pentoxifylline: Its pharmacokinetics and ability to improve tumour perfusion and radiosensitivity in mice
18. 2 in a manner compatible with its ability to increase relative tumour perfusion
19. Regional perfusion and oxygenation of tumors upon methylxanthine derivative administration
20. Increases in tumor response by pentoxifylline alone or in combination with nicotinamide
21. Improved turnout oxygenation and radiosensitization by combination with nicotinamide and pentoxifylline
22. Changes in turnout blood flow, oxygenation and interstitial fluid pressure induced by pentoxifylline
23. Diltiazem enhances tumor blood flow: MRI study in a murine tumor
24. Characterization of the WIDR: A human colon carcinoma cell line
25. Pharmacokinetics, binding and distribution of Hoechst 33342 in spheroids and murine turnouts
26. Regional blood flow by fractional distribution of indicators
27. Increase in tumor oxygenation and radiosensitivity caused by pentoxifylline
28. Increase in tumor blood flow by pentoxifylline
29. The histological structure of some human lung cancers and the possible implications for radiotherapy
30. The use of fluorescent probes to identify regions of transient perfusion in murine tumors
31. Use of a carbocyanine dye as a marker of functional vasculature in murine tumours
32. United Kingdom co-ordinating committee on cancer research (UKCCR) guidelines for the welfare of animals in experimental neoplasia
33. Improvement of tissue perfusion with inhibitors of calcium ion influx
34. Modification of tumour response by calcium antagonists in the SCCVII/St tumour implanted at two different sites
35. Cells at intermediate oxygen levels can be more important than the "hypoxic fraction" in determining tumor response to fractionated radiotherapy
36. 86Rb