Effect of bile acids on the uptake of irinotecan and its active metabolite, SN-38, by intestinal cells

Biochimica et Biophysica Acta - General Subjects

Volumn 1525, Issue 1-2, 2001, Pages 125-129

  Kobayashi, Kunihiko ^a,b,c   Ceryak, Susan ^a   Matsuzaki, Yasushi ^d   Shoji, Kudoh ^b   Bouscarel, Bernard ^a,e  

^a GEORGE WASHINGTON UNIVERSITY MEDICAL CENTER   (United States)

^b NIPPON MEDICAL SCHOOL   (Japan)

^c SAITAMA CANCER CENTER   (Japan)

^d UNIVERSITY OF TSUKUBA   (Japan)

^e GEORGE WASHINGTON UNIVERSITY SCHOOL OF MEDICINE AND HEALTH SCIENCES   (United States)

Author keywords

7 Ethyl 10 hydroxycamptothecin; Bile acid; Intestinal absorption; Irinotecan; Micelle; Taurocholic acid

Indexed keywords

7 ETHYL 10 HYDROXYCAMPTOTHECIN; BILE ACID; CHOLIC ACID; IRINOTECAN; TAUROCHOLIC ACID;

ANIMAL CELL; ARTICLE; CELL ISOLATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; EPITHELIUM CELL; HYDROLYSIS; INTESTINE ABSORPTION; INTESTINE CELL; MICELLE; NONHUMAN; PH MEASUREMENT; PRIORITY JOURNAL;

ANIMALS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; BILE ACIDS AND SALTS; BIOLOGICAL TRANSPORT, ACTIVE; CAMPTOTHECIN; CHOLIC ACID; CRICETINAE; DNA TOPOISOMERASES, TYPE I; ENZYME INHIBITORS; HYDROGEN-ION CONCENTRATION; INTESTINES; MESOCRICETUS; MICELLES; TAUROCHOLIC ACID;

CRICETINAE;

EID: 0035895750     PISSN: 03044165     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-4165(00)00179-3     Document Type: Article

References (20)

1. Intracellular roles of SN-38, a metabolite of the camptothecin derivative CPT-11, in the antitumor effect of CPT-11
2. Conversion of irinotecan (CPT-11) to its active metabolite, 7-ethyl-10-hydroxycamptothecin (SN-38), by human liver carboxylesterase
3. Identification of the metabolites of irinotecan, a new derivative of camptothecin, in rat bile and its biliary excretion
4. Pharmacokinetics of irinotecan and its metabolites in human blood, bile, and urine
5. Involvement of beta-glucuronidase in intestinal microflora in the intestinal toxicity of the antitumor camptothecin derivative irinotecan hydrochloride (CPT-11) in rats
6. PH-dependent uptake of irinotecan and its active metabolite, SN-38, by intestinal cells
7. A kinetic and mechanistic study of the hydrolysis of camptothecin and some analogues
8. Kinetic studies of the hydrolysis and lactonization of camptothecin and its derivatives, CPT-11 and SN-38, in aqueous solution
9. A physicochemical approach to the intraluminal phase of fat absorption
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11. Linolenic acid transport in hamster intestinal cells is carrier-mediated
12. pH dependence of micellar diffusion and dissociation
13. Signal transduction and hepatocellular bile acid transport: Cross talk between bile acids and second messengers
14. Intestinal absorption of bile acids in the rabbit: Different transport rates in jejunum and ileum
15. Distribution and monomer activity of cholesterol in micellar bile salt: Effect of cholesterol level
16. Physicochemical and physiological mechanisms for the effects of food on drug absorption: The role of lipids and pH
17. A phase II study of CPT-11, a new derivative of camptothecin, for previously untreated non-small-cell lung cancer
18. A phase III multicenter randomized study of CPT-11 versus supportive care (SC) alone in patients (Pts) with 5FU-resistant metastatic colorectal cancer (MCRC)
19. Phase I and pharmacologic study of irinotecan in combination with cisplatin for advanced lung cancer
20. Reduced irinotecan-induced side effect by oral alkalization