Schwann cells express active agrin and enhance aggregation of acetylcholine receptors on muscle fibers

Journal of Neuroscience

Volumn 21, Issue 24, 2001, Pages 9572-9584

  Yang, Jie Fei ^a   Cao, Guan ^a   Koirala, Samir ^a   Reddy, Linga V ^a   Ko, Chien Ping ^a  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

Author keywords

Acetylcholine receptors; Agrin; Complement; Frog; Glia; Muscle; Nerve regeneration; Neuromuscular junction; Schwann cells

Indexed keywords

AGRIN; CHOLINERGIC RECEPTOR;

ANIMAL CELL; ARTICLE; FROG; MUSCLE CELL; NERVE REGENERATION; NEUROMUSCULAR SYNAPSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SCHWANN CELL;

EID: 0035894865     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.21-24-09572.2001     Document Type: Article

References (53)

1. Tripartite synapses: Glia, the unacknowledged partner
2. Perisynaptic Schwann cells at neuromuscular junctions revealed by a novel monoclonal antibody
3. The role of glial cells in synaptic function
4. Effects of purified recombinant neural and muscle agrin on skeletal muscle fibers in vivo
5. Studies on cultured rat Schwann cells. I. Establishment of purified populations from cultures of peripheral nerve
6. The effect of Schwann cells on acetylcholine receptor aggregates in Xenopus nerve-muscle cultures
7. 2+ internal stores at the neuromuscular synapse
8. Extension of synaptic extracellular matrix during nerve terminal sprouting in living frog neuromuscular junctions
9. The remodeling of synaptic extra-cellular matrix and its dynamic relationship with nerve terminals at living frog neuromuscular junctions
10. Accumulation of acetylcholine receptors at nerve-muscle contacts in culture
11. Full-length agrin isoform activities and binding site distributions on cultured Xenopus muscle cells
12. RNA spicing regulates agrin-mediated acetylcholine receptor clustering activity on cultured myotubes
13. The ability of agrin to cluster AChRs depends on alternative splicing and on cell surface proteoglycans
14. Early events in neuromuscular junction formation in vitro: Induction of acetylcholine receptor clusters in the postsynaptic membrane and morphology of newly formed synapses
15. Synaptic regulation of glial protein expression in vivo
16. Sequence and expression patterns of two forms of the middle molecular weight neurofilament protein (N F-M) of Xenopus laevis
17. Acetylcholine receptor-aggregating activity of agrin isoforms and mapping of the active site
18. Acetylcholine receptor-aggregating proteins are associated with the extracellular matrix of many tissue in Torpedo
19. The role of perisynaptic Schwann cells in development of neuromuscular junctions in the frog (Xenopus laevis)
20. Heparin inhibits acetylcholine receptor aggregation at two distinct steps in the agrin-induced pathway
21. Complement-mediated lysis with monoclonal antibodies
22. The localization of cholinesterase activity in rat cardiac muscle by electron microscopy
23. A lectin, peanut agglutinin, as a probe for the extracellular matrix in living neuromuscular junction
24. Synaptic remodeling revealed by repeated in vivo observations and electron microscopy of identified frog neuromuscular junctions
25. Denervated skeletal muscle fibers develop discrete patches of high acetylcholine receptor density
26. The Schwann cell at the neuromuscular junction
27. Reciprocal interactions between perisynaptic Schwann cells and regenerating nerve terminals at the frog neuromuscular junction
28. Distribution of agrin mRNAs in the chick embryo nervous system
29. Distribution of acetylcholine receptors at frog neuromuscular junctions with a discussion of some physiological implications
30. The agrin hypothesis
31. Identification of agrin, a synaptic organizing protein from Torpedo electric organ
32. In vivo observations of terminal Schwann cells at normal, denervated, and reinnervated mouse neuromuscular junctions
33. Do Schwann cells play a role in aggregation of acetylcholine receptors at the neuromuscular junction?
34. Selective ablation of perisynaptic Schwann cells from the frog neuromuscular junction in vivo
35. Terminal Schwann cells elaborate extensive processes following denervation of the motor endplate
36. Modulation of synaptic efficacy and synaptic depression by glial cells at the frog neuromuscular junction
37. Agrin orchestrates synaptic differentiation at the vertebrate neuromuscular junction
38. The agrin gene codes for a family of basal lamina proteins that differ in function and distribution
39. Development of the vertebrate neuromuscular junction
40. Normal conduction of surface action potentials in detubulated amphibian skeletal muscle fibres
41. Cell-specific regulation of agrin RNA splicing in the chick ciliary ganglion
42. Schwann cell processes guide regeneration of peripheral axons
43. Nerve sprouting in muscle is induced and guided by processes extended by Schwann cells
44. Schwann cells induce and guide sprouting and reinnervation of neuromuscular junctions
45. Study on the induction of spontaneous transmitter release at early nerve-muscle contacts in Xenopus cultures
46. cDNA that encodes active agrin
47. Mechanism of agrin-induced acetylcholine receptor aggregation
48. Aggregates of acetylcholine receptors are not observed under anti-agrin staining Schwann cell processes at the frog neuromuscular junction
49. Expression of agrin by Schwann cells at intact, degenerating and developing nerves
50. Neu differentiation factor (NDF) and the neuregulin (NRG) family