Bile salt tauroursodeoxycholic acid modulation of bax translocation to mitochondria protects the liver from warm ischemia-reperfusion injury in the rat

Transplantation

Volumn 72, Issue 11, 2001, Pages 1803-1807

  Ishigami, Fumitaka ^a   Naka, Shigeyuki ^a   Takeshita, Kazuyoshi ^a   Kurumi, Yoshimasa ^a   Hanasawa, Kazuyoshi ^a   Tani, Tohru ^a  

^a SHIGA UNIVERSITY OF MEDICAL SCIENCE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ASPARTATE AMINOTRANSFERASE; BILE SALT; COMPLEMENTARY DNA; MESSENGER RNA; PROTEIN BAX; TAUROURSODEOXYCHOLIC ACID;

ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; CONTROLLED STUDY; HISTOLOGY; LIVER CELL; LIVER FUNCTION TEST; LIVER ISCHEMIA; LIVER TRANSPLANTATION; MALE; MITOCHONDRIAL MEMBRANE; NONHUMAN; ORGAN TRANSPLANTATION; PRIORITY JOURNAL; PROTEIN TRANSPORT; RAT; REPERFUSION INJURY; SIGNAL TRANSDUCTION;

EID: 0035892910     PISSN: 00411337     EISSN: None     Source Type: Journal    
DOI: 10.1097/00007890-200112150-00016     Document Type: Article

References (41)

1. A multi-center double-blind controlled trial of ursodeoxycholic acid for primary biliary cirrhosis
2. Effect of tauroursodeoxycholic acid on bile acid-induced apoptosis and cytolysis in rat hepatocytes
3. Effect of tauroursodeoxycholic acid on bile flow and calcium excretion in ischemia-reperfusion injury of rat livers
4. Caspases: Enemies within
5. Mitochondria and apoptosis
6. Bcl-2 gene family in the nervous system
7. The Bcl-2 protein family: Arbiters of cell survival
8. Role of Bcl-2 proteins in apoptosis: Apoptosomes or mitochondria?
9. Bid, a Bcl2 interacting protein, mediates cytochrome c release from mitochondria in response to activation of cell surface death receptors
10. Movement of Bax from the cytosol to mitochondria during apoptosis
11. Bax directly induces release of cytochrome c from isolated mitochondria
12. A multicenter, controlled trial of ursodiol for the treatment of primary biliary cirrhosis
13. Management of intrahepatic cholestasis in pregnancy
14. Effects of ursodeoxycholic acid and taurine on serum liver enzymes and bile acids in chronic hepatitis
15. Tauroursodeoxycholate prevents biliary protein excretion induced by other bile salts in the rat
16. Ursodeoxycholate reduces hepatotoxicity of bile salts in primary human hepatocytes
17. Taurodeoxycholate prevents taurolithocholate-induced cholestasis and toxicity in rat liver
18. Tauroursodeoxycholate reduces ischemic damage in human allografts: A biochemical and ultrastrucrural study
19. Tauroursodeoxycholate ameliorates reperfusion injury after pig liver transplantation
20. In vivo protection of the pig liver against ischemia/reperfusion injury by tauroursodeoxycholate
21. Distinction of apoptotic and necrotic cell death by in situ labeling of fragmented DNA
22. Markers of allograft viability in the rat. Relationship between transplantation viability and liver function in the isolated perfused rat liver
23. Molecular aspects of membrane stabilization by ursodeoxycholate
24. Activation of apoptosis during the reperfusion phase after rat liver ischemia
25. Preservation and reperfusion injuries in liver allografts: An overview and synthesis of current studies
26. Increase in survival time of liver transplants by protease inhibitors and a calcium channel blocker, nisoldipine
27. Evidence of the existence of a soluble mediator of cold preservation injury
28. Inhibition of nonlysosomal calcium-dependent proteolysis by glycine during anoxic injury of rat hepatocytes
29. An increase in cytosolic protease activity during liver preservation: Inhibition by glutathione and glycine
30. The role of calcium ions and calcium channel entry blockers in experimental ischemia-reperfusion-induced liver injury
31. Current status of calcium in hepatocellular injury
32. The role of cysteine proteases in hypoxia-induced rat renal proximal tubular injury
33. Verapamil improves rat hepatic preservation with UW solution
34. Protective effect of aprotinin on ischemic hepatocellular damage
35. Calcium-dependent proteolysis and its inhibition in the ischemic rat myocardium
36. Inhibition of Bax channel-forming activity by Bcl-2
37. Comparison of the ion channel characteristics of pro-apoptotic BAX and anti-apoptotic BCL-2
38. Cytoprotection by Bcl-2 requires the pore-forming α5 and α6 helices
39. Cytosol-to-membrane redistribution of Bax and Bcl-XL during apoptosis
40. Nonionic detergents induce dimerization among membrane of the Bcl-2 family
41. Bax in murine thymus is a soluble monomeric protein that displays differential detergent-induced conformations