Myelin phagocytosis and remyelination of macrophage-enriched central nervous system aggregate cultures

Journal of Neuroscience Research

Volumn 66, Issue 6, 2001, Pages 1173-1178

  Copelman, Cheryl A ^a   Diemel, Lara T ^a   Gveric, Djordje ^b   Gregson, Norman A ^a   Louise Cuzner, M ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

Central nervous system; Macrophage; Microglia; Multiple sclerosis; Myelination

Indexed keywords

MYELIN; MYELIN BASIC PROTEIN;

ANIMAL CELL; ARTICLE; BRAIN CELL; CELL CULTURE; CELL POPULATION; CENTRAL NERVOUS SYSTEM; CONTROLLED STUDY; CULTURE MEDIUM; DEMYELINATION; MICROGLIA; MULTIPLE SCLEROSIS; NONHUMAN; PATHOGENESIS; PERITONEUM MACROPHAGE; PHAGOCYTOSIS; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN SYNTHESIS; RAT; REMYELINIZATION;

ADULT; ANIMALS; ANTIBODIES; ANTIGENS, CD; ANTIGENS, CD147; ANTIGENS, NEOPLASM; ANTIGENS, SURFACE; AVIAN PROTEINS; BLOOD PROTEINS; BRAIN; CELL COUNT; CELL SIZE; CELLS, CULTURED; ECTODYSPLASINS; FETUS; HUMANS; IMMUNOHISTOCHEMISTRY; MACROPHAGES; MEMBRANE GLYCOPROTEINS; MEMBRANE PROTEINS; MIDDLE AGED; MULTIPLE SCLEROSIS; MYELIN BASIC PROTEINS; MYELIN SHEATH; MYELIN-ASSOCIATED GLYCOPROTEIN; NERVE REGENERATION; PEPTIDE FRAGMENTS; PHAGOCYTOSIS; RATS; RATS, SPRAGUE-DAWLEY;

EID: 0035892675     PISSN: 03604012     EISSN: None     Source Type: Journal    
DOI: 10.1002/jnr.10026     Document Type: Article

References (34)

1. An improved radioimmunoassay for myelin basic protein-like immunoreactive material in cerebrospinal fluid
2. Macrophages: Their myelinotrophicor neurotoxic actions depend upon tissue oxidative stress
3. Differential ultrastructural localization of myelin basic protein, myelin/oligodendroglial glycoprotein, and 2′,3′-cyclic nucleotide 3′-phosphodiesterase in the CNS of adult rats
4. Temporal analysis of growth factor mRNA expression in myelinating rat brain aggregate cultures: Increments in CNTF, FGF-2, IGF-I, and PDGF-AA mRNA are induced by antibody-mediated demyelination
5. Molecular biology of microglia
6. Macrophages in CNS remyelination: Friend or foe?
7. The glial scar and central nervous system repair
8. Failure of remyelination in areas of demyelination produced in the spinal cord of old rats
9. Secreted peptides as regulators of neuron-gila and glia-glia interactions in the developing nervous system
10. Delayed remyelination in rat spinal cord following ethidium bromide injection
11. Stimulation of in vitro myelin synthesis by microglia
12. Biochemical differentiation in serum-free aggregating brain cell cultures
13. Transitory macrophages in the white matter of the developing visual cortex. II. Development and relations with axonal pathways
14. Demyelination induced in aggregating brain cell cultures by a monoclonal antibody against myelin/oligodendrocyte glycoprotein
15. Insulin-like growth factor I (IGF I) stimulates DNA synthesis in fetal rat brain cell cultures
16. Labelling of amoeboid microglial cells in the supraventricular corpus callosum following the application of horseradish peroxidase in the cerebrum and spinal cord in rats
17. Characterization and distribution of phagocytic macrophages in multiple sclerosis plaques
18. Light and electron microscopic demonstration of non-specific esterase in amoeboid microglial cells in the corpus callosum in postnatal rats: A cytochemical link to monocytes
19. Antibody responses in chronic relapsing experimental allergic encephalomyelitis: Correlation of serum demyelinating activity with antibody titre to the myelin/oligodendrocyte glycoprotein (MOG)
20. A novel myelin-associated glycoprotein defined by a mouse monoclonal antibody
21. Myelin basic protein content of aggregating rat brain cell cultures treated with cytokines and/or demyelinating antibody: Effects of macrophage enrichment
22. Myelination and remyelination of aggregate rat brain cell cultures enriched with macrophages
23. Protein measurement with Folin phenol reagent
24. Myelination in rat brain aggregating cell cultures
25. Macrophages and the nervous system
26. The fine structure of chronically active multiple sclerosis plaques
27. Multiple sclerosis: Remyelination of nascent lesions
28. Biology of disease. Analysis of autoimmune demyelination: Its impact upon multiple sclerosis
29. Immunoglobulins promote remyelination in the central nervous system
30. Remyelination occurs as extensively but more slowly in old rats compared to young rats following gliotoxin-induced CNS demyelination
31. Morphometric analysis of normal, mutant, and transgenic CNS: Correlation of myelin basic protein expression to myelinogenesis
32. Interleukin-12 induces relapse in experimental allergic encephalomyelitis in the Lewis rat
33. Morphological differentiation of mechanically dissociated fetal rat brain in aggregating cell cultures
34. The cerebrospinal fluid in multiple sclerosis