Protein kinase inhibitors and the dynamics of tight junction opening and closing in A6 cell monolayers

Journal of Membrane Biology

Volumn 184, Issue 2, 2001, Pages 185-196

  Lacaz Vieira, F ^a   Jaeger, M M ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

Calcium; Claudin 1; Fast Ca++ switch assay; H7; Paracellular conductance; Protein kinase C; Protein kinases; Staurosporine; Tight junction; ZO 1

Indexed keywords

CALCIUM ION; CELL PROTEIN; CLAUDIN; PROTEIN KINASE; PROTEIN KINASE C; PROTEIN KINASE INHIBITOR; PROTEIN Z0 1; STAUROSPORINE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CALCIUM TRANSPORT; CELL MEMBRANE PERMEABILITY; CONTROLLED STUDY; ELECTRIC CONDUCTIVITY; MOLECULAR DYNAMICS; MONOLAYER CULTURE; NONHUMAN; PROTEIN LOCALIZATION; TIGHT JUNCTION;

1-(5-ISOQUINOLINESULFONYL)-2-METHYLPIPERAZINE; ANIMALS; CALCIUM; CARRIER PROTEINS; CELL LINE; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; KINETICS; MEMBRANE PROTEINS; PHOSPHOPROTEINS; PLANT PROTEINS; PROTEIN KINASE C; STAUROSPORINE; TIGHT JUNCTIONS; XENOPUS;

ANIMALIA; PHOCIDAE;

EID: 0035890238     PISSN: 00222631     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00232-001-0082-5     Document Type: Article

References (59)

1. The structure and regulation of tight junctions
2. Tight junctions: Closing in on the seal
3. Structure, regulation, and pathophysiology of tight junctions in the gastrointestinal tract
4. Assembly and sealing of tight junctions: Possible participation of G-proteins, phospholipase C, protein kinase C and calmodulin
5. Assembly of the tight junction: The role of diacylglycerol
6. Transmembrane proteins of tight junctions
7. Physiological and pathological factors affecting the tight junctions
8. Protein kinase C in the transduction of signals toward and within the cell nucleus
9. NO modulates the apicolateral cytoskeleton of isolated hepatocytes by a PKC-dependent, cGMP-independent mechanism
10. 2+ reverses this effect
11. Tight junctions
12. Tight junctions and apical/basolateral polarity
13. Polarized monolayers formed by epithelial cells on a permeable and translucent support
14. Protein kinase inhibitors prevent junction dissociation induced by low extracellular calcium in MDCK epithelial cells
15. The molecular organization of tight junctions
16. Phosphorylation of the tight junction protein cingulin and the effects of protein kinase inhibitors and activators in MDCK epithelial cells
17. Cytoskeletal involvement in the modulation of cell-cell junctions by the protein kinase inhibitor H-7
18. Protein kinase C - A question of specificity
19. Different effects of protein kinase inhibitors on the localization of junctional proteins at cell-cell contact sites
20. Molecular structure and assembly of the tight junction
21. Identification of isoforms of G proteins and PKC that colocalize with tight junctions
22. Transformation-sensitive localization of alpha-protein kinase C at cell-cell contacts in rat renal proximal tubule epithelial cells
23. Cellular variability in the development of tight junctions after activation of protein kinase C
24. Claudin-1 and -2: Novel integral membrane proteins localizing at tight junctions with no sequence similarity to occludin
25. Extracellular calcium and the organization of tight junctions in pancreatic acinar cells
26. MAGUK proteins: Structure and role in the tight junction
27. Tight junction formation in cultured epithelial cells (MDCK)
28. 2+ directly regulates tight junctional permeability in the human cervical cell line CaSki
29. Cell adhesion molecules in epithelia
30. The role of the cell adhesion molecule uvomorulin in the formation and maintenance of epithelial junctional complex
31. Disruption of epithelial tight junctions is prevented by cyclic nucleotide-dependent protein kinase inhibitors
32. Tight junctions of the blood-brain barrier
33. Sodium flux in the apical membrane of the toad skin: Aspects of its regulation and the importance of the ionic strength of the outer solution upon the reversibility of amiloride inhibition
34. 2+-related tight junction events
35. Tight junction dynamics: Oscillations and the role of protein kinase C
36. Small synthetic peptides homologous to segments of the first external loop of occludin impair tight junction resealing
37. Tight junction dynamics in the frog urinary bladder
38. Experimental modulation of occluding junctions in a cultured transporting monolayer
39. ++-dependent disassembly and reassembly of occluding junctions in guinea pig pancreatic acinar cells
40. Overexpression of protein kinase C-delta increases tight junction permeability in LLC-PK1 epithelia
41. Effects of diacylglycerols on LLC-PK1 renal epithelia: Similarity to phorbol ester tumor promoters
42. The effects of teleocidin and aplysiatoxin tumor promoters on epithelial tight junctions and transepithelial permeability: Comparison to phorbol esters
43. Hormonal regulation of paracellular permeability in isolated rat hepatocyte couplets
44. The role of phosphorylation in development of tight junctions in cultured renal epithelial (MDCK) cells
45. 2+-independent regulation of the thyroid epithelial junction complex by protein kinases
46. Vinculin but not □-actinin is a target of PKC phosphorylation during junctional assembly induced by calcium
47. Protein kinase C-alpha activity modulates transepithelial permeability and cell junctions in the LLC-PK1 epithelial cell line
48. Endothelial cells: Adhesion and tight junctions
49. The cell biology of the blood-brain barrier
50. Possible involvement of phosphorylation of occludin in tight junction formation
51. Structure, function, and regulation of cellular tight junctions
52. Effects of calcium depletion on the junctional complex between oxyntic cells of gastric glands
53. Regulation of paracellular permeability in Caco-2 cell monolayers by protein kinase C
54. Identification of ZO-1: A high molecular weight polypeptide associated with the tight junction (Zonula occludens) in a variety of epithelia
55. Regulated assembly of tight junctions by protein kinase C
56. PKC-dependent regulation of transepithelial resistance: Roles of MLC and MLC kinase
57. Identification of a putative cell adhesion domain of uvomorulin
58. Synergistic effects of Ca2+ ionophore and activators of protein kinase C on epithelial paracellular permeability