Marked anemic hypoxia deteriorates cerebral hemodynamics and brain metabolism during massive intracerebral hemorrhage

Journal of the Neurological Sciences

Volumn 190, Issue 1-2, 2001, Pages 3-10

  Lee, E Jian ^a   Hung, Yu Chang ^a  

^a NATIONAL CHENG KUNG UNIVERSITY   (Taiwan)

Author keywords

Anaerobic glycolysis; Anemic hypoxia; Brain oxygenation; Cerebral hemodynamics; Intracerebral hemorrhage

Indexed keywords

LACTIC ACID; OXYGEN;

ANEMIA; ANIMAL; ARTICLE; BLOOD; BLOOD PRESSURE; BRAIN; BRAIN CIRCULATION; BRAIN HEMORRHAGE; BRAIN HYPOXIA; DISEASE MODEL; DOG; ENERGY METABOLISM; FEMALE; GLYCOLYSIS; HEMODYNAMICS; ISCHEMIC PRECONDITIONING; MALE; METABOLISM; METHODOLOGY; OXYGEN CONSUMPTION; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; VASCULARIZATION;

ANEMIA; ANIMALS; BLOOD PRESSURE; BRAIN; CEREBRAL HEMORRHAGE; CEREBROVASCULAR CIRCULATION; DISEASE MODELS, ANIMAL; DOGS; ENERGY METABOLISM; FEMALE; GLYCOLYSIS; HEMODYNAMIC PROCESSES; HYPOXIA, BRAIN; ISCHEMIC PRECONDITIONING; LACTIC ACID; MALE; OXYGEN; OXYGEN CONSUMPTION;

EID: 0035885720     PISSN: 0022510X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0022-510X(01)00567-6     Document Type: Article

References (36)

1. Brierley JB. Cerebral hypoxia. In: Blackwood W, Corsellis JAN, editors. Greenfield's neuropathology. London: Edward Arnold Publishers 1976:43-85.
2. Maroko PR, Braunwald E. Effects of metabolic and pharmacologic interventions on myocardial infarct size following coronary occlusion. Acta Med Scand, Suppl 1976;587:125-36.
3. Rosenthal DS, Braunwald E. Anemia and cardiovascular disorders. In: Braunwald E, editor. Heart disease: a textbook of cardiovascular medicine. Philadelphia: WB Saunders 1988:781-2.
4. Miller JD, Sweet RC, Narayan R, Becker DP. Early insults to the injured brain. JAMA 1978;240:439-42.
5. Todd MM, Wu B, Warner DS. The hemispheric cerebrovascular response to hemodilution is attenuated by a focal cryogenic brain injury. J Neurotrauma 1994;11:149-60.
6. Reasoner DK, Ryu KH, Hindman BJ, Cutkomp J, Smith T. Marked hemodilution increases neurologic injury after focal cerebral ischemia in rabbits. Anesth Analg 1996;82:61-7.
7. Dearden NM. Mechanisms and prevention of secondary brain damage during intensive care. Clin Neuropathol 1998;17:221-8.
8. Lee EJ, Hung YC, Lee MY. Anemic hypoxia in moderate intracerebral hemorrhage: the alterations of cerebral hemodynamics and brain metabolism. J Neurol Sci 1999;164:117-23.
9. Lee EJ, Hung YC, Lee MY. Early alterations in cerebral hemodynamics, brain metabolism, and blood-brain barrier permeability in experimental intracerebral hemorrhage. J Neurosurg 1999;91:1013-9.
10. Lim RKS, Liu CN, Moffit RL. A stereotaxic atlas of the dog's brain. Illinois: C.C. Thomas 1960.
11. Aaslid R, Markwalder TM, Nornes H. Noninvasive transcranial Doppler ultrasound recording of flow velocity in basal cerebral arteries. J Neurosurg 1982;57:769-74.
12. Osborne KA, Shigeno T, Balarsky AM, Ford I, McCulloch J, Teasdale GM, et al. Quantitative measurement of early brain damage in a rat model of focal cerebral ischemia. J Neurol, Neurosurg Psychiatry 1987;50:402-10.
13. Robertson CS, Narayan RK, Gokaslan ZL, Pahwa R, Grossman RG, Caram Jr. P, et al. Cerebral arteriovenous oxygen difference as an estimate of cerebral blood flow in comatose patients. J Neurosurg 1989;70:222-30.
14. Xu BN, Yabuki A, Mishina H, Miyazaki M, Maeda M, Ishii S. Pathophysiology of brain swelling after acute experimental brain compression and decompression. Neurosurgery 1993;32:289-96.
15. Nath FP, Jenkins A, Mendelow AD, Graham DI, Teasdale GM. Early hemodynamic changes in experimental intracerebral hemorrhage. J Neurosurg 1986;65:697-703.
16. Nath FP, Kelly PT, Jenkins A, Mendelow AD, Graham DI, Teasdale GM. Effects of experimental intracerebral hemorrhage on blood flow, capillary permeability, and histochemistry. J Neurosurg 1987; 66:555-62.
17. Nehls DG, Mendelow AD, Graham DI, Teasdale GM. Experimental intracerebral hemorrhage: early removal of a spontaneous mass lesion improves late outcome. Neurosurgery 1990;27:674-82.
18. Yang GY, Betz AL, Chenevert TL, Brunberg JA, Hoff JT. Experimental intracerebral hemorrhage: relationship between brain edema, blood flow, and blood-brain barrier permeability in rats. J Neurosurg 1994;81:93-102.
19. Lee EJ, Chio CC, Lin HJ, Yang LH, Chen HH. Application of transcranial Doppler sonography in surgical aspects of hypertensive putaminal haemorrhage. Acta Neurochir 1996;138:60-7.
20. Kiyohara Y, Fujishima M, Ishitsuka T, Tamaki K, Sadoshima S, Omae T. Effects of hematocrit on brain metabolism in experimental induced cerebral ischemia in spontaneously hypertensive rats (SHR). Stroke 1985;16:835-40.
21. Hirakata H, Yao H, Osato S, Ibayashi S, Onoyama K, Otsuka M, et al. CBF and oxygen metabolism in hemodialysis patients: effects of anemia correction with recombinant human EPO. Am J Physiol 1992;262:F737-43.
22. Matsuoka T, Saiki C, Mortola JP. Metabolic and ventilatory responses to anemic hypoxia in conscious rats. J Appl Physiol 1994; 77:1067-72.
23. Vorstrup S, Lass P, Waldemar G, Brandi L, Schmidt JF, Johnsen A, et al. Increased cerebral blood flow in anemic patients on long-term hemodialytic treatment. J Cereb Blood Flow Metab 1992;12:745-9.
24. van der Hoeven MA, Maertzdorf WJ, Blanco CE. Relationship between mixed venous oxygen saturation and markers of tissue oxygenation in progressive hypoxic hypoxia and in isovolemic anemic hypoxia in 8- to 12-day-old piglets. Crit Care Med 1999;27: 1885-92.
25. Dexter F, Hindman BJ. Effects of haemoglobin concentration on brain oxygenation in focal stroke: a mathematical modeling study. Br J Anaesth 1997;79:346-51.
26. de Groot H, Littauer A. Hypoxia, reactive oxygen, and cell injury. Free Radical Biol Med 1989;6:541-51.
27. Janssens D, Michiels C, Delaive E, Eliaers F, Drieu K, Remacle J. Protection of hypoxia-induced ATP decrease in endothelial cells by ginkgo biloba extract and bilobalide. Biochem Pharmacol 1995;50: 991-9.
28. McDonough KH, Spitzer JJ. Effects of hypoxia and reoxygenation on adult rat heart cell metabolism. Proc Soc Exp Biol Med 1983; 173:519-26.
29. Cruz J, Jaggi JL, Hoffstad OJ. Cerebral blood flow and oxygen consumption in acute brain injury with acute anemia: an alternative for the cerebral metabolic rate of oxygen consumption? Crit Care Med 1993;21:1218-24.
30. Cruz J, Hoffstad OJ, Jaggi JL. Cerebral lactate-oxygen index in acute brain injury with acute anemia: assessment of false versus true ischemia. Crit Care Med 1994;22:1465-70.
31. Inao S, Marmarou A, Clarke GD, Andersen BJ, Fatouros PP, Young HF. Production and clearance of lactate from brain tissue, cerebrospinal fluid, and serum following experimental brain injury. J Neurosurg 1988;69:736-44.
32. Combs DJ, Dempsey RJ, Maley M, Donaldson D, Smith C. Relationship between plasma glucose, brain lactate, and intracellular pH during cerebral ischemia in gerbils. Stroke 1990;21:936-42.
33. Stys PK. Anoxic and ischemic injury of myelinated axons in CNS white matter: from mechanistic concepts to therapeutics. J Cereb Blood Flow Metab 1998;18:2-25.
34. Ohene-Frempong K, Weiner SJ, Sleeper LA, Miller ST, Embury S, Moohr JW, et al. Cerebrovascular accidents in sickle cell disease: rates and risk factors. Blood 1998;91:288-94.
35. Adams RJ, McKie VC, Hsu L, Files B, Vichinsky E, Pegelow C, et al. Prevention of a first stroke by transfusions in children with sickle cell anemia and abnormal results on transcranial Doppler ultrasonography. N Engl J Med 1998;339:5-11.
36. Bullock MR, Lyeth BG, Muizelaar JP. Current status of neuroprotection trials for traumatic brain injury: lessons from animal models and clinical studies. Neurosurgery 1999;45:207-20.