Effect of intracerebral 6-nitronoradrenaline, an endogenous catechol-O-methyltransferase (COMT) inhibitor, on striatal dopamine metabolism in anaesthetised rats

Journal of Neuroscience Methods

Volumn 109, Issue 1, 2001, Pages 47-52

  Huotari, M ^a   Passlin, M ^a   Nordberg, H L ^a   Forsberg, M ^a   Kotisaari, S ^a   Tuomisto, L ^a   Shintani, F ^b   Tanaka, K F ^b   Reenila I ^b   Laitinen, K ^a   Mannisto P T ^a  

^a KEIO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b UNIVERSITY OF HELSINKI   (Finland)

Author keywords

6 Nitrodopamine; 6 Nitronoradrenaline; Brain microdialysis; COMT inhibition; Dopamine reuptake; Tolcapone

Indexed keywords

5 NITROHOMOVALLINIC ACID; 6 NITRO 3,4 DIHYDROXYPHENYLACETIC ACID; 6 NITRODOPAMINE; 6 NITRONORADRENALINE; AMINE OXIDASE (FLAVIN CONTAINING) ISOENZYME B; CATECHOL; CATECHOL METHYLTRANSFERASE; CATECHOL METHYLTRANSFERASE INHIBITOR; DOPAMINE; DOPAMINE TRANSPORTER; LEVODOPA; NORADRENALIN DERIVATIVE; TOLCAPONE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; CELL LEVEL; CONFERENCE PAPER; CONTROLLED STUDY; CORPUS STRIATUM; DOPAMINE BRAIN LEVEL; DOPAMINE METABOLISM; DOPAMINE UPTAKE; ENZYME INHIBITION; MALE; MICRODIALYSIS; NONHUMAN; PERFUSION; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; RAT;

3,4-DIHYDROXYPHENYLACETIC ACID; ANIMALS; BENZOPHENONES; BINDING, COMPETITIVE; CARRIER PROTEINS; CATECHOL O-METHYLTRANSFERASE; DOPAMINE; DOPAMINE PLASMA MEMBRANE TRANSPORT PROTEINS; DOPAMINE UPTAKE INHIBITORS; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; EXTRACELLULAR SPACE; HOMOVANILLIC ACID; MALE; MEMBRANE GLYCOPROTEINS; MEMBRANE TRANSPORT PROTEINS; MICRODIALYSIS; MONOAMINE OXIDASE; NEOSTRIATUM; NERVE TISSUE PROTEINS; NEURONS; NITRIC OXIDE; NITROPHENOLS; NOREPINEPHRINE; PIPERAZINES; RATS; RATS, WISTAR;

EID: 0035882411     PISSN: 01650270     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0165-0270(01)00400-9     Document Type: Article

References (23)

1. Extracellular concentrations of dopamine and metabolites in the rat caudate after oral administration of a novel catechol-O-methyltransferase inhibitor Ro 40-7592
2. The dopamine inhibitor GBR 12909: Selectivity and molecular mechanism of action
3. Nitration of catecholamines with nitrogen oxides in mild conditions
4. Oxidation and nitration of catecholamines by nitrogen oxides derived from nitric oxide
5. Nitric oxide-induced nitration of catecholamine neurotransmitters: A key to neuronal degeneration?
6. Microdialysis studies on the action of tolcapone on pharmacologically-elevated extracellular dopamine levels in conscious rats
7. Effects of COMT inhibitors on striatal dopamine metabolism: A microdialysis study
8. General properties and clinical possibilities of new selective inhibitors of catechol O-methyltransferase (COMT)
9. 2-norepinephrine increases norepinephrine release and inhibits norepinephrine uptake in rat spinal synaptosomes
10. No change of brain extracellular catecholamine levels after acute COMT inhibition: A microdialysis study in anaesthetized rats
11. Effect of nitecapone and clorgyline, given intracerebroventricularly, on L-dopa metabolism in the rat brain
12. Characteristics of catechol O-methyltransferase (COMT) and properties of selective COMT inhibitors
13. Catechol O-methyltransferase (COMT) and COMT inhibitors
14. Effects of tolcapone, a novel catechol-O-methyltransferase inhibitor on striatal metabolism of L-DOPA and dopamine in rats
15. Determination of monoamine oxidase B activity by high-performance liquid chromatography
16. Determination of catechol-O-methyltransferase activity by high-pressure liquid chromatography with electrochemical detection
17. Nitrite- and peroxide-dependent oxidation pathways of dopamine: 6-Nitrodopamine and 6-hydroxydopamine formation as potential contributory mechanisms of oxidative stress- and nitric oxide induced neurotoxicity in neuronal degeneration
18. Improved assay of reaction products to quantitate catechol-O-methyltransferase (COMT) activity by high-performance liquid chromatography with coulometric detection
19. Bioactive 6-nitronorepinephrine identified in mammalian brain
20. Comparison of two new inhibitors of catechol O-methyltransferase on striatal dopamine metabolism: A microdialysis study in rats
21. Minor effect of tolcapone, a catechol-O-methyltransferase inhibitor, on extracellular dopamine levels modified by amphetamine or pargyline: A microdialysis study in anaesthetized rats
22. Potent COMT inhibition by Ro-40-7592 in the periphery and in the brain: Preclinical and clinical findings