Lipopolysaccharide and interferon-γ-induced nitric oxide production and protein oxidation in mouse peritoneal macrophages are affected by glutathione peroxidase-1 gene knockout

Free Radical Biology and Medicine

Volumn 31, Issue 4, 2001, Pages 450-459

  Fu, Yangxin ^a   McCormick, Charles C ^a   Roneker, Carol ^a   Lei, Xin Gen ^a  

^a Department of Molecular Biology and Genetics   (United States)

Author keywords

Aminoguanidine; Diquat; Free radicals; GPX1; Interferon ; Lipopolysaccharide; Macrophages; Nitric oxide; Protein oxidation

Indexed keywords

AMINOGUANIDINE; DIETHYLDITHIOCARBAMIC ACID; DIQUAT; DNA FRAGMENT; GAMMA INTERFERON; GLUTATHIONE PEROXIDASE; ISOENZYME; LIPOPOLYSACCHARIDE; NITRIC OXIDE;

ANIMAL CELL; ARTICLE; CELL PROTECTION; CELL VIABILITY; CONTROLLED STUDY; ENZYME ACTIVITY; KNOCKOUT GENE; KNOCKOUT MOUSE; MACROPHAGE ACTIVATION; MOUSE; NITRATION; NONHUMAN; OXIDATION; PERITONEUM MACROPHAGE; PRIORITY JOURNAL; PROTEIN SYNTHESIS; WESTERN BLOTTING;

ANIMALS; BLOTTING, WESTERN; CELL SURVIVAL; CELLS, CULTURED; CHELATING AGENTS; DITIOCARB; DNA FRAGMENTATION; ENZYME INHIBITORS; FREE RADICALS; GLUTATHIONE PEROXIDASE; GUANIDINES; INTERFERON TYPE II; LIPOPOLYSACCHARIDES; MACROPHAGES, PERITONEAL; MICE; MICE, KNOCKOUT; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NITRITES; RNA, MESSENGER; SUPEROXIDE DISMUTASE;

EID: 0035882263     PISSN: 08915849     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0891-5849(01)00607-4     Document Type: Article

References (51)

1. Nitric oxide and macrophage function
2. Nitric oxide synthases: Roles, tolls, and controls
3. Nitric oxide: Pathophysiological mechanisms
4. Heat shock proteins and macrophage resistance to the toxic effects of nitric oxide
5. Nitric oxide-mediated apoptosis in murine peritoneal macrophage
6. Nitric oxide induces macrophage death by apoptosis
7. Prevention of the expression of inducible nitric oxide synthase by aminoguanidine or aminoethyl-isothiourea in macrophage and in the rat
8. Peroxynitrite formation from macrophage-derived nitric oxide
9. Reactions between nitric oxide, superoxide, and peroxynitrite: Footprints of peroxynitrite in vivo
10. Superoxide and peroxynitrite generation from inducible nitric oxide synthase in macrophages
11. Reactive species in ischemic rat lung injury: Contribution of peroxynitrite
12. Peroxynitrite contributes to the candidacidal activity of nitric oxide-producing macrophages
13. Bipyridylium quaternary salts and related compounds. V. Pulse radiolysis studies of the reaction of paraquat radical with oxygen. Implications for the mode of action of bipyridyl herbicides
14. Pathogenesis of diquat-induced liver necrosis in selenium-deficient rats: Assessment of the roles of lipid peroxidation and selenoprotein P
15. Knockout of cellular glutathione peroxidase gene renders mice susceptible to diquat-induced oxidative stress
16. Low-level exposure to diquat induces a neurally mediated intestinal hypersecretion in rats: Involvement of nitric oxide and mast cells
17. Protein oxidation in aging, disease, and oxidative stress
18. Differential susceptibility of plasma proteins to oxidative modification: Examination by western blot immunoassay
19. Quantitation of nitrotyrosine levels in the lung sections of patients and animals with acute lung injuries
20. Contribution of reactive oxygen and nitrogen species to particulate-induced lung injury
21. Increased production of the potent oxidant peroxynitrite in the lungs of patients with idiopathic pulmonary fibrosis
22. Peroxynitrite inhibits T lymphocyte activation and proliferation by promoting impairment of tyrosine phosphorylation and peroxynitrite-driven apoptotic death
23. Oxidative damage linked to neurodegeneration by selective alpha-synuclein nitration in synucleinopathy lesions
24. ALS, SOD and peroxynitrite
25. Nitration and inactivation of manganese superoxide dismutase in chronic rejection of human renal allografts
26. Decreased zinc affinity of amyotrophic lateral sclerosis-associated superoxide dismutase mutants leads to enhanced catalysis of tyrosine nitration by peroxynitrite
27. Association of increased immunostaining for inducible nitric oxide synthase and nitrotyrosine with fibroblast growth factor transformation in pancreatic cancer
28. The chemistry of peroxynitrite: A product from the reaction of nitric oxide with superoxide
29. Endogenously produced peroxynitrite induces the oxidation of mitochondiral and nuclear proteins in immunostimulated macrophages
30. Strategies of antioxidant defense
31. Selenium: Biochemical role as a component of glutathione peroxidase
32. Tissue-specific functions of individual glutathione peroxidases
33. Cellular glutathione peroxidase is the mediator of body selenium to protect against paraquat lethality in transgenic mice
34. Superoxide dismutase and hydrogen peroxide cause rapid nitric oxide breakdown, peroxynitrite production and subsequent cell death
35. Oxygen tension limits nitric oxide synthesis by activated macrophages
36. 15N] nitrate in biological fluids
37. Protein measurement with the Folin phenol reagent
38. Glutathione peroxidase activity in rat lens and other tissues in relation to dietary selenium intake
39. Spectrophotometric assay for superoxide dismutase based on tetrazolium salt 3′-1-(phenylamino)-carbonyl-3,4-tetrazlium]-bis (4-methoxy-6-nitro) benzenesulfonic acid hydrate reduction by xanthine-xanthine oxidase
40. Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays
41. Cell mediated cytotoxicity against U 937 cells by human monocytes and macrophages in a modified colorimetric MTT assay
42. Mice deficient in the cellular glutathione peroxidase develop normally and show no increased sensitivity to hyperoxia
43. Cellular glutathione peroxidase knockout mice express normal levels of selenium-dependent plasma and phospholipid hydroperoxide glutathione peroxidase in various tissues
44. Mice with a homozygous null mutation for the most abundant glutathione peroxidase, Gpx1, show increased susceptibility to the oxidative stress-inducing agents paraquat and hydrogen peroxide
45. Augmentation of cytokine-induced nitric oxide synthesis by hydrogen peroxide
46. N-acetyl cysteine inhibits induction of NO production by endotoxin or cytokine stimulated rat peritoneal macrophage, C6 glial cells and astrocytes
47. Promoter of the mouse gene encoding calcium-independent nitric oxide synthase confers inducibility by interferon gamma and bacterial lipopolysaccharide
48. Role of transcription factor NF-kappa B/Rel in induction of nitric oxide synthase
49. Inhibition of I kappa B-alpha phosphorylation and degradation and subsequent NF-kappa B activation by glutathione peroxidase overexpression
50. Selenium-dependent cellular glutathione peroxidase protects mice against a pro-oxidant-induced oxidation of NADPH, NADH, lipids, and protein
51. Superoxide formation and macrophage resistance to nitric oxide-mediated apoptosis