Effect of Bw4 and Bw6 epitope mismatches on antibody production, acute and chronic rejection, and graft survival in renal allografts

Transplantation

Volumn 72, Issue 3, 2001, Pages 433-437

  Leffell, Mary S ^a,c   Kraus, Edward ^a   Racusen, Lorraine C ^a   Ratner, Lloyd E ^a   Charney, Douglas ^b   Zachary, Andrea A ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b ST LUKE S ROOSEVELT HOSPITAL CENTER   (United States)

^c Immunogenetics Laboratory   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AZATHIOPRINE; CYCLOSPORIN; EPITOPE; HLA B ANTIGEN; HLA BW4 ANTIGEN; HLA BW6 ANTIGEN; IMMUNOGLOBULIN G ANTIBODY; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; UNCLASSIFIED DRUG;

ANTIBODY PRODUCTION; ANTIBODY SPECIFICITY; ARTICLE; CADAVER KIDNEY; CHRONIC KIDNEY DISEASE; COMPLEMENT DEPENDENT CYTOTOXICITY; ENZYME LINKED IMMUNOSORBENT ASSAY; EPITOPE MAPPING; FEMALE; GRAFT REJECTION; GRAFT SURVIVAL; HAPLOTYPE; HLA SYSTEM; HOMOZYGOSITY; HUMAN; HUMORAL IMMUNITY; INCIDENCE; KIDNEY ALLOGRAFT; KIDNEY TRANSPLANTATION; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; RISK ASSESSMENT;

EID: 0035881790     PISSN: 00411337     EISSN: None     Source Type: Journal    
DOI: 10.1097/00007890-200108150-00013     Document Type: Article

References (18)

1. Epitope map of the HLA-B7 CREG using afffinity-purified alloantibody probes
2. The primary structure of HLA-A32 suggests a region involved in formation of the Bw4/Bw6 epitopes
3. Genetic and serological heterogeneity of the supertypic HLA-B locus specificities Bw4 and Bw6
4. HLA-A9 antibodies and epitopes
5. Epitope specificity of HLA Class I alloantibodies: I. Frequency analysis of antibodies to private versus public specificities in potential transplant recipients
6. Bw4/Bw6 matching and renal allograft survival in homozygous recipients
7. The basic lymphocyte microcytotoxicity test
8. Detection of HLA class I-specific antibodies by the QuikScreen enzyme-linked immunosorbent assay
9. Long-term follow-up in London Transplant Group recipients of cadaver renal allografts, the influence of HLA matching on transplant outcome
10. Epitope specificity of HLA class I alloantibodies: II. Stability of cross-reactive group antibody patterns over extended time periods
11. The Bw4/Bw6 difference between HLA-B*0802 and HLA-B*0801 changes the peptides endogenously bound and the stimulation of alloreactive T cells
12. Recognition of an HLA public determinant(Bw4) by human allogeneic cytotoxic T lymphocytes
13. T cells can recognize the allospecificities formed by the substitution of amino acids associated with HLA-Bw4/Bw6 public epitopes
14. The significance of the anti-class I response. II. Clinical and pathologic features of anti-class I-mediated rejection
15. Induction of high affinity fibroblast growth factor receptor expression and proliferation in human endothelial cells by anti-HLA antibodies: A possible mechanism for transplant atherosclerosis
16. Anti-HLA antibodies after solid organ transplantation
17. Characterization of HLA class I-specific antibodies by ELISA using solubilized antigen targets. II. Clinical relevance
18. The humoral immune response against an HLA class I allodeterminant correlates with the HLA-DR phenotype of the responder