Regulation of human papillomavirus type 1 replication by the viral E2 protein

Virology

Volumn 287, Issue 1, 2001, Pages 214-224

  Van Horn, Gerald ^a   Sheikh, Saifuddin ^a   Khan, Saleem A ^a  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

Author keywords

Cervical cancer; DNA replication; E1 protein; E2 protein; Human papillomaviruses; Origin of replication

Indexed keywords

PROTEIN E2; UNCLASSIFIED DRUG; VIRUS DNA; VIRUS PROTEIN;

ARTICLE; COMPLEX FORMATION; DNA REPLICATION; HUMAN; HUMAN CELL; MODEL; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN PROTEIN INTERACTION; REGULATORY MECHANISM; UTERINE CERVIX CANCER; VIRUS CARCINOGENESIS; VIRUS REPLICATION; WART VIRUS;

EID: 0035881464     PISSN: 00426822     EISSN: None     Source Type: Journal    
DOI: 10.1006/viro.2001.1037     Document Type: Article

References (56)

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19. Transcriptional activation function is not required for stimulation of DNA replication by bovine papillomavirus type 1 E2
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21. Crystal structure at 1.7 Å of the bovine papillomavirus-1 E2 DNA-binding domain bound to its DNA target
22. Selective extraction of polyoma DNA from infected mouse cell cultures
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24. The activation domain of the bovine papillomavirus E2 protein mediates association of DNA-bound dimers to form DNA loops
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28. Bovine papillomavirus type 1 E1 and simian virus 40 large T antigen share regions of sequence similarity required for multiple functions
29. E2 polypeptides encoded by bovine papillomavirus type 1 form dimers through the common carboxyl-terminal domain: Transactivation is mediated by the conserved amino-terminal domain
30. Bovine papillomavirus with a mutation in the E2 serine 301 phosphorylation site replicates at a high copy number
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33. Cooperative binding of the E2 protein of bovine papillomavirus to adjacent E2-responsive sequences
34. DNA bending is induced in an enhancer by the DNA-binding domain of the bovine papillomavirus E2 protein
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37. Amino acids necessary for DNA contact and dimerization imply novel motifs in the papillomavirus E2 trans-activator
38. Bovine papillomavirus E2 repressor mutant displays a high-copy-number phenotype and enhanced transforming activity
39. Co-operative interaction between the initiator E1 and the transcriptional activator E2 is required for replication of bovine papillomavirus in vivo and in vitro
40. The papillomavirus E1 protein forms a DNA-dependent hexameric complex with ATPase and DNA helicase activities
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42. Bovine papillomavirus (BPV)-encoded E1 protein contains multiple activities required for BPV DNA replication
43. Evidence for cooperativity between E2 binding sites in E2 trans-regulation of bovine papillomavirus type 1
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51. The transactivation and DNA binding domains of the BPV-1 E2 protein have different roles in cooperative origin binding with the E1 protein
52. Activation of BPV-1 replication in vitro by the transcription factor E2
53. The E1 protein of bovine papillomavirus 1 is an ATP-dependent DNA helicase
54. Human papillomaviruses