Combined FTY720/cyclosporine treatment promotes graft survival and lowers the peripheral lymphocyte count in a murine cardiac allotransplantation model

Transplantation

Volumn 72, Issue 1, 2001, Pages 168-171

  Nikolova, Zariana ^a   Hof, Akiko ^a   Baumlin, Yves ^a   Hof, Robert P ^a  

^a NOVARTIS PHARMA AG   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLOSPORIN; FINGOLIMOD;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG BLOOD LEVEL; DRUG EFFICACY; FEMALE; GRAFT SURVIVAL; HEART GRAFT; HEART TRANSPLANTATION; INFLAMMATION; LYMPHOCYTE; LYMPHOCYTE COUNT; MOUSE; NONHUMAN; PRIORITY JOURNAL; RADIOIMMUNOASSAY;

ANIMALS; CYCLOSPORINE; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG COMBINATIONS; FEMALE; GRAFT SURVIVAL; HEART TRANSPLANTATION; IMMUNOSUPPRESSIVE AGENTS; LYMPHOCYTE COUNT; MICE; MICE, INBRED BALB C; MICE, INBRED C3H; PROPYLENE GLYCOLS; SPHINGOSINE; TRANSPLANTATION, HETEROTOPIC; TRANSPLANTATION, HOMOLOGOUS;

EID: 0035879255     PISSN: 00411337     EISSN: None     Source Type: Journal    
DOI: 10.1097/00007890-200107150-00033     Document Type: Article

References (10)

1. FTY720: A novel immunosuppressant, induces sequestration of circulating mature lymphocytes by acceleration of lymphocyte homing in rats. I. FTY720 selectively decreases the number of circulating mature lymphocytes by acceleration of lymphocyte homing
2. FTY720, a novel immunosuppressant, induces sequestration of circulating mature lymphocytes by acceleration of lymphocyte homing in rats. II. FTY720 prolongs skin allograft survival by decreasing T cell infiltration into grafts but not cytokine production in vivo
3. FTY720: A novel transplantation drug that modulates lymphocyte traffic rather than activation
4. A novel immunosuppressant, FTY720, with a unique mechanism of action, induces long-term graft acceptance in rat and dog allotransplantation
5. Prophylaxis of acute renal allograft rejection using FTY720 in combination with subtherapeutic doses of cyclosporine
6. Immunosuppressive effects of FTY720 alone or in combination with cyclosporine and/or sirolimus
7. FTY720, a new immunosuppressant, promotes long-term graft survival and inhibits the progression of graft coronary artery disease in a murine model of cardiac transplantation
8. Prevention of graft vessel disease by combined FTY720/cyclosporine A treatment in a rat carotid artery transplantation model
9. Primarily vascularized allografts of hearts in mice
10. A working formulation for the standardization of nomenclature in the diagnosis of heart and lung rejection: Heart rejection study group