Monomeric class I molecules mediate TCR/CD3ε/CD8 interaction on the surface of T cells

Journal of Immunology

Volumn 167, Issue 2, 2001, Pages 821-826

  Block, M S ^a   Johnson, A J ^a   Mendez Fernandez, Y ^a   Pease, L R ^a  

^a MAYO CLINIC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALLOPHYCOCYANIN; CD3 ANTIGEN; CD8 ANTIGEN; FLUORESCEIN ISOTHIOCYANATE; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; T LYMPHOCYTE RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIGEN BINDING; ARTICLE; CELL SURFACE; CONTROLLED STUDY; FLOW CYTOMETRY; FLUORESCENCE; GEL FILTRATION; MOUSE; NONHUMAN; PHOSPHORYLATION; PRIORITY JOURNAL; T LYMPHOCYTE ACTIVATION; TRANSGENIC MOUSE;

EID: 0035879126     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.167.2.821     Document Type: Article

References (28)

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2. CD4 and CD8 accessory molecules function through interactions with major histocompatibility complex molecules which are not directly associated with the T cell receptor-antigen complex
3. Recognition by CD8 on cytotoxic T lymphocytes is ablated by several substitutions in the class I alpha 3 domain: CD8 and the T-cell receptor recognize the same class I molecule
4. A binding site for the T-cell co-receptor CD8 on the α3 domain of HLAA2
5. CD8 enhances formation of stable T-cell receptor/MHC class I molecule complexes
6. T cell receptor and coreceptor CD8 αα bind peptide-MHC independently and with distinct kinetics
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13. lck to the activated T cell receptor/ CD3/ζ complex
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