Absence of crabtree effect in human melanoma cells adapted to growth at low pH: Reversal by respiratory inhibitors

Cancer Research

Volumn 61, Issue 14, 2001, Pages 5630-5635

  Burd, Randy ^a   Wachsberger, Phyllis R ^a   Biaglow, John E ^b   Wahl, Miriam L ^a   Lee, Intae ^b   Leeper, Dennis B ^a  

^a THOMAS JEFFERSON UNIVERSITY   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

(3 IODOBENZYL)GUANIDINE; 2,4 DINITROPHENOL; GLUCOSE; LACTIC ACID;

ACIDIFICATION; ARTICLE; CELL GROWTH; CONTROLLED STUDY; GLYCOLYSIS; HUMAN; HUMAN CELL; HYPERGLYCEMIA; MELANOMA CELL; METABOLIC INHIBITION; MITOCHONDRIAL RESPIRATION; OXYGEN CONSUMPTION; OXYGENATION; PH; PRIORITY JOURNAL;

3-IODOBENZYLGUANIDINE; CELL CYCLE; CELL DIVISION; DOSE-RESPONSE RELATIONSHIP, DRUG; GLUCOSE; HUMANS; HYDROGEN-ION CONCENTRATION; IODINE RADIOISOTOPES; LACTIC ACID; MELANOMA; MITOCHONDRIA; OXYGEN CONSUMPTION; TIME FACTORS; TUMOR CELLS, CULTURED;

EID: 0035879044     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (29)

1. Blood flow, oxygen and nutrient supply, and metabolic microenvironment of human tumors: A review
2. Über den stoffwechsel der carcinomzelle
3. pH studies in human malignant tumours
4. Sensitization of clonogenic malignant cells to hyperthermia by glucose-mediated, tumor-selective pH reduction
5. Tumor-selective modification of cellular microenvironment in vivo: Effect of glucose infusion on the pH in normal and malignant rat tissues
6. Human tumor extracellular pH as a function of blood glucose concentration
7. pH in human tumour xenografts: Effect of intravenous administration of glucose
8. Comparison between tumor pH and cell sensitivity to heat in R1F-1 tumors
9. Response of tumours to hyperglycaemia: Characterization, significance and role in hyperthermia
10. Hydrogen ion-mediated enhancement of cytotoxicity of bischloroethylating drugs in rat mammary carcinoma cells in vitro
11. pH dependence of mitomycin C-induced cross-linking activity in EMT6 tumor cells
12. Potentiation of DNA-adduct formation and cytoxicity of platinum containing drugs by low pH
13. Regulation of pH in murine tumor and muscle
14. Are cancer cells acidic?
15. Altered proton extrusion in cells adapted to growth at low extracellular pH
16. The role of intracellular pH and its variance in low pH sensitization of killing by hyperthermia
17. Impaired mitochondrial respiration and stimulated glycolysis by m-iodobenzylguanidine (MIBG)
18. MIBG inhibits respiration: Potential for radio- and hyperthermic sensitization
19. Reduction of intratumoral pH by the mitochondrial inhibitor m-iodobenzylguanidine and moderate hyperglycemia
20. Bioavailability and toxicity after oral administration of m- iodobenzylguanidine (MIBG)
21. 125I]iodobenzylguanidine in the human neuroblastoma cell line SK-N-SH
22. Modification of radiation response through glucose-controlled respiration
23. Intracellular inhibition of mono(ADP-ribosylation) by meta- iodobenzylguanidine: Specificity, intracellular concentration and effects on glucocorticoid-mediated cell lysis
24. Observation on the carbohydrate metabolism of tumours
25. Hexokinase binding to mitochondria: A basis for proliferative energy metabolism
26. Glucose phosphorylation in tumor cells. Cloning, sequencing, and overexpression in active form of a full-length cDNA encoding a mitochondrial bindable form of hexokinase
27. Intracellular pH governs the subcellular distribution of hexokinase in a glioma cell line
28. Early stimulation of acidification rate by novel cytotoxic pyridyl cyanoguanidines in human tumor cells: Comparison with m-iodobenzylguanidine
29. Effect of glucose +/- MIBG on the radiation response of R3230 AC tumors