Endogenous release of tissue factor pathway inhibitor by topical application of an ointment containing mucopolysaccharide polysulfate to nonhuman primates

Thrombosis Research

Volumn 103, Issue 2, 2001, Pages 157-163

  Hoppensteadt, Debra A ^a   Fareed, Jawed ^a   Raake, Phillip ^a   Raake, Wolfram ^b  

^a LOYOLA UNIVERSITY CHICAGO   (United States)

^b Sankyo Pharma GmbH   (Germany)

Author keywords

Anti inflammatory; Anticoagulant; Mucopolysaccharide polysulfate; Ointment; Tissue factor pathway inhibitor

Indexed keywords

GLYCOSAMINOGLYCAN POLYSULFATE; PLACEBO; TISSUE FACTOR PATHWAY INHIBITOR;

ANIMAL EXPERIMENT; ANTICOAGULATION; ANTIINFLAMMATORY ACTIVITY; ARTICLE; BLOOD CLOTTING; CONTROLLED STUDY; DRUG MECHANISM; MONKEY; NONHUMAN; PARTIAL THROMBOPLASTIN TIME; PRIORITY JOURNAL; THROMBOCYTE COUNT;

ADMINISTRATION, CUTANEOUS; ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; BLOOD COAGULATION TESTS; DRUG EVALUATION, PRECLINICAL; ENDOTHELIUM, VASCULAR; FACTOR XA; FEMALE; FIBRINOLYTIC AGENTS; GLYCOSAMINOGLYCANS; LIPOPROTEINS; MACACA MULATTA; MALE; OINTMENTS; PLATELET COUNT;

EID: 0035878979     PISSN: 00493848     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0049-3848(01)00280-8     Document Type: Article

References (16)

1. Effects of exercise and polysulfated glycosaminoglycan on the development of osteoarthritis in equine carpal joints with osteochondral defects
2. Polysulfated glycosaminoglycan in the treatment of osteoarthritis
3. Evaluation of polysulfated glycosaminoglycan for the treatment of hip dysplasia in dogs
4. Mobilat cream in the therapy of acute distortions. Placebo-controlled double-blind study
5. Non-steroidal antirheumatic ointments in the treatment of primary periarticular and intramuscular fibrositis
6. Conservative treatment of inflammatory and degenerative diseases in orthopedics and general practice
7. Quantitative systematic overview of topically applied non-steroidal anti-inflammatory drugs
8. Comparison of heparin and a semi-synthetic heparin analogue, A73025: I. Kinetics of clearance from the circulation of man following intravenous injection
9. Inhibition of human elastase from polymorphonuclear leucocytes by a glycosaminoglycan polysulfate (Arteparon)
10. Heparin induces release of extrinsic coagulation pathway inhibitor (EPI)
11. The lipoprotein-associated coagulation inhibitor that inhibits factor VII-tissue factor complex also inhibits factor Xa: Insight into possible mechanisms of action
12. Antithrombotic effect of a mucopolysaccharide polysulfate after systemic, topical and percutaneous application
13. Treatment of superficial thrombophlebitis: A randomized double-blind trial of heparinoid cream
14. A primate model (Macaca mulatta) to study the pharmacokinetics of heparin and its fractions
15. Tissue factor pathway inhibitor for cardiovascular disorders
16. Effect of repeated aprosulate and enoxaparin administration on tissue factor pathway inhibitor antigen levels