Site-directed removal of N-glycosylation sites in BST-1/CD157: Effects on molecular and functional heterogeneity

Biochemical Journal

Volumn 357, Issue 2, 2001, Pages 385-392

  Yamamoto Katayama, S ^a   Sato, A ^a   Ariyoshi, M ^a   Suyama, M ^a   Ishihara, K ^a   Hirano, T ^a   Nakamura, H ^a   Morikawa, K ^a   Jingami, H ^a  

^a Biomolec Engg Research Institute   (Japan)

Author keywords

ADP ribosyl cyclase; Crystallization; Cyclic ADP ribose; Glycosylphosphatidylinositol anchored protein; Post translational modification

Indexed keywords

ANIMAL CELL CULTURE; BIOASSAY; CALCIUM; ENZYMES; MUTAGENESIS; VIRUSES;

FUNCTIONAL HETEROGENEITY;

MOLECULAR BIOLOGY;

ADENOSINE DIPHOSPHATE RIBOSE; ADENOSINE DIPHOSPHATE RIBOSYL CYCLASE; BONE MARROW STROMAL CELL ANTIGEN 1; CD157 ANTIGEN; CELL ANTIGEN; HYDROLASE; MUTANT PROTEIN; POLYPEPTIDE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CALCIUM CELL LEVEL; CONTROLLED STUDY; CRYSTAL; ENZYME ACTIVITY; GENETIC ENGINEERING; INTRACELLULAR TRANSPORT; NONHUMAN; PRIORITY JOURNAL; PROTEIN FOLDING; PROTEIN GLYCOSYLATION; PROTEIN MODIFICATION; PROTEIN POLYMORPHISM; PROTEIN PROCESSING; PROTEIN PURIFICATION; PROTEIN SECRETION; SITE DIRECTED MUTAGENESIS;

ADP-RIBOSYL CYCLASE; AMINO ACID SEQUENCE; ANIMALS; ANTIGENS, CD; ANTIGENS, CD38; ANTIGENS, DIFFERENTIATION; ANTIGENS, SURFACE; BACULOVIRIDAE; CELL LINE; CRYSTALLOGRAPHY, X-RAY; GENE EXPRESSION REGULATION; GLYCOSYLATION; HUMANS; MAMMALS; MEMBRANE GLYCOPROTEINS; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; NAD+ NUCLEOSIDASE; PROTEIN CONFORMATION; RECOMBINANT PROTEINS; SPODOPTERA; TRANSFECTION; TUNICAMYCIN;

ANIMALIA; INSECTA; MAMMALIA; UNIDENTIFIED BACULOVIRUS;

EID: 0035878868     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/0264-6021:3570385     Document Type: Article

References (31)

1. Modulator and messenger functions of cyclic ADP-ribose in calcium signaling
2. 2+ in a protist, Euglena gracilis
3. Abscisic acid signaling through cyclic ADP-ribose in plants
4. Novel mechanism of intracellular calcium release in pituitary
5. Purification and characterization of a molluscan egg-specific NADase, a second-messenger enzyme
6. + into a calcium-mobilizing metabolite
7. Isolation of a cDNA encoding the human CD38 (T10) molecule, a cell surface glycoprotein with an unusual discontinuous pattern of expression during lymphocyte differentiation
8. BST-1, a surface molecule of bone marrow stromal cell lines that facilitates pre-B-cell growth
9. + glycohydrolase
10. The reaction mechanism for CD38. A single intermediate is responsible for cyclization, hydrolysis, and base-exchange chemistries
11. A covalent intermediate in CD38 is responsible for ADP-ribosylation cyclization reactions
12. CD38 functions are regulated through an internalization step
13. The transmembrane glycoprotein CD38 is a catalytically active transporter responsible for generation and influx of the second messenger cyclic ADP-ribose across membranes
14. Regulation of calcium signalling in T-lymphocytes by the second messenger cyclic ADP-ribose
15. Novel peptide inhibitor of ecto-ADP-ribosyl cyclase of bone marrow stromal cell antigen-1 (BST-1/CD157)
16. Inhibitor peptide SNP-1 binds to a soluble form of BST-1/CD157 at a 2:2 stoichiometry
17. Glycoproteins
18. Primary Structural requirements for the enzymatic formation of the N-glycosidic bond in glycoproteins
19. Rapid and efficient site-specific mutagenesis without phenotypic selection
20. Elevated levels of the soluble form of bone marrow stromal cell antigen 1 in the sera of patients with severe rheumatoid arthritis
21. ADP ribosyl cyclase activity of a novel bone marrow stromal cell surface molecule, BST-1
22. Human BST-1 expressed on myeloid cells functions as a receptor molecule
23. Enzymatic synthesis and characterization of cyclic GDP-ribose
24. ProMod and Swiss-Model: Internet-based tools for automated comparative protein modelling
25. Crystal structure of Aplysia ADP ribosyl cyclase, a homologue of the bifunctional ectozyme CD38
26. BST-1/CD157 regulates the humoral immune responses in vivo
27. Novel kinetics, behaviour and cell-type specificity of CD157-mediated tyrosine kinase signalling
28. Human CD38 (ADP-ribosyl cyclase) is a counter-receptor of CD31, an Ig superfamily member
29. Functional role of glycosylation on the recombinant CD38/ADP-ribosyl cyclase in CHO cells
30. Site-directed removal of N-glycosylation sites in the bovine cation-dependent mannose 6-phosphate receptor: Effects on ligand binding, intracellular targeting and association with binding immunoglobulin protein
31. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding