Cytotoxic T cell activity against the peptide, AYRARALEL, from Yo protein of patients with the HLA A24 or B27 supertype and paraneoplastic cerebellar degeneration

Journal of the Neurological Sciences

Volumn 188, Issue 1-2, 2001, Pages 61-65

  Tanaka, Masami ^a   Tanaka, Keiko ^b   Tsuji, Shoji ^b   Kawata, Akihiro ^c   Kojima, Sigeyuki ^d   Kurokawa, Tomomi ^e   Kira, Jun ichi ^e   Takiguchi, Masafumi ^f  

^a Natl West Niigata Central Hospital   (Japan)

^b NIIGATA UNIVERSITY   (Japan)

^c TOKYO METROPOLITAN NEUROLOGICAL HOSPITAL   (Japan)

^d Matsudo Municipal Hospital   (Japan)

^e KYUSHU UNIVERSITY   (Japan)

^f KUMAMOTO UNIVERSITY   (Japan)

Author keywords

Anti Hu antibodies; Anti Yo antibodies; Cytotoxic T cells; Paraneoplastic cerebellar degeneration; Paraneoplastic neurological syndromes; Reverse immunogenetics

Indexed keywords

ALANYLTYROSYLARGINYLALANYLARGINYLALANYLLEUCYLGLUTAMYLLEUCINE; BRAIN PROTEIN; CD8 ANTIGEN; CHROMIUM 51; INTERLEUKIN 2; PROTEIN ANTIBODY; PROTEIN YO; PROTEIN YO ANTIBODY; UNCLASSIFIED DRUG;

ARTICLE; CELL MEDIATED CYTOTOXICITY; CELL SELECTION; CLINICAL ARTICLE; CONTROLLED STUDY; FLOW CYTOMETRY; HUMAN; HUMAN CELL; MONONUCLEAR CELL; PARANEOPLASTIC NEUROPATHY; PRIORITY JOURNAL; PROTEIN BINDING; TARGET CELL;

AUTOANTIGENS; CEREBELLAR DISEASES; DNA-BINDING PROTEINS; EPITOPES; HLA-A ANTIGENS; HLA-B27 ANTIGEN; HUMANS; NEOPLASM PROTEINS; NERVE DEGENERATION; NERVE TISSUE PROTEINS; PARANEOPLASTIC SYNDROMES; PEPTIDE FRAGMENTS; T-LYMPHOCYTES, CYTOTOXIC;

EID: 0035878566     PISSN: 0022510X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0022-510X(01)00548-2     Document Type: Article

References (11)

1. Paraneoplastic neurologic syndromes: Pathogenesis and physiopathology
2. Trial to establish an animal model of paraneoplastic cerebellar degeneration with anti-Yo antibody: I. Mouse strains bearing different MHC molecules produce antibodies on immunization with recombinant Yo protein, but do not cause Purkinje cell loss
3. Passive transfer and active immunization with the recombinant leucine-zipper (Yo) protein as an attempt to establish an animal model of paraneoplastic cerebellar degeneration
4. HLA A24 in paraneoplastic cerebellar degeneration with anti-Yo antibody
5. Sub-acute cerebellar degeneration with anti-Yo autoantibodies: Immunohistochemical analysis of the immune reaction in the central nervous system
6. Cytotoxic T cells against a peptide from Yo protein in patients with paraneoplastic cerebellar degeneration with anti-Yo antibody
7. Tumor-specific killer cells in paraneoplastic cerebellar degeneration
8. HLA-B* 3501-peptide interactions: Role of anchor residues of peptides in their binding to HLA-B* 3501 molecules
9. Nine major HLA class I supertypes account for the vast preponderance of HLA-A and -B polymorphism
10. A peptide with the binding motif of the HLA B7 supertype reacts with CD 8-positive cytotoxic T cells in anti-Hu syndrome
11. HLA-A31- and HLA-Aw68-restricted cytotoxic T cell responses to a single hepatitis B virus nucleocapsid epitope during acute viral hepatitis