PKCγ contributes to a subset of the NMDA-dependent spinal circuits that underlie injury-induced persistent pain

Journal of Neuroscience

Volumn 21, Issue 14, 2001, Pages 5321-5327

  Martin, W J ^a   Malmberg, A B ^a   Basbaum, A I ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Mustard oil; NMDA; Persistent pain; Protein kinase C; Spinal cord; Isoform

Indexed keywords

ALLYL ISOTHIOCYANATE; ISOPROTEIN; N METHYL DEXTRO ASPARTIC ACID; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; PROTEIN KINASE C; AMINO ACID RECEPTOR BLOCKING AGENT; ISOENZYME; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; N METHYLASPARTIC ACID; PLANT EXTRACT; PROTEIN KINASE C GAMMA; VEGETABLE OIL;

ALLODYNIA; ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ELECTROPHYSIOLOGY; ENZYME MECHANISM; INJURY; MECHANICAL STIMULATION; MOUSE; NERVE CELL EXCITABILITY; NEUROTRANSMISSION; NOCICEPTION; NONHUMAN; PAIN; PRIORITY JOURNAL; RECEPTOR BLOCKING; SPINAL CORD; STIMULUS RESPONSE; THERMAL STIMULATION; ACTION POTENTIAL; ANIMAL; BRASSICA; CHEMICALLY INDUCED DISORDER; DISEASE MODEL; DRUG ANTAGONISM; DRUG EFFECT; GENETICS; HYPERALGESIA; METABOLISM; MOUSE MUTANT; NEURALGIA; PAIN ASSESSMENT; PATHOPHYSIOLOGY; POSTERIOR HORN CELL; STIMULATION;

ACTION POTENTIALS; ANIMALS; BEHAVIOR, ANIMAL; DISEASE MODELS, ANIMAL; EXCITATORY AMINO ACID ANTAGONISTS; HYPERALGESIA; ISOENZYMES; MICE; MICE, KNOCKOUT; MUSTARD PLANT; N-METHYLASPARTATE; NEURALGIA; PAIN MEASUREMENT; PHYSICAL STIMULATION; PLANT EXTRACTS; PLANT OILS; POSTERIOR HORN CELLS; PROTEIN KINASE C; RECEPTORS, N-METHYL-D-ASPARTATE; SPINAL CORD;

EID: 0035878076     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.21-14-05321.2001     Document Type: Article

References (44)

1. Modified hippocampal long-term potentiation in PKC gamma-mutant mice
2. PKC gamma mutant mice exhibit mild deficits in spatial and contextual learning
3. Chronic hypersensitivity for inflammatory nociceptor sensitization mediated by the epsilon isozyme of protein kinase C
4. The ventral dendritic arbor of marginal (lamina I) neurons in the adult primate spinal cord
5. Protein kinase C modulation of NMDA currents: An important link for LTP induction
6. Physiology and morphology of substantia gelatinosa neurons intracellularly stained with horseradish peroxidase
7. Potent analgesic effects of GDNF in neuropathic pain states
8. Contribution of protein kinase C to central sensitization and persistent pain following tissue injury
9. The role of excitatory amino acid receptors and intracellular messengers in persistent nociception after tissue injury in rats
10. Dynamic receptive field plasticity in rat spinal cord dorsal horn following C-primary afferent input
11. The late results of antero-lateral cordotomy for pain relief
12. Exposure of rat spinal neurones to NMDA, AMPA and kainate produces only short-term enhancements of responses to noxious and non-noxious stimuli
13. Multiple overlapping processes underlying short-term synaptic enhancement
14. Golgi studies of the neurons in layer I and II of the dorsal horn of the medulla (trigeminal nucleus caudalis)
15. Expansion of receptive fields of spinal lamina I projection neurons in rats with unilateral adjuvant-induced inflammation: The contribution of dorsal horn mechanisms
16. An intracellular analysis of amino acid induced excitations of deep dorsal horn neurones in the rat spinal cord slice
17. Nociceptor modulated central sensitization causes mechanical hyperalgesia in acute chemogenic and chronic neuropathic pain
18. Involvement of spinal protein kinase C in induction and maintenance of both persistent spontaneous flinching reflex and contralateral heat hyperalgesia induced by subcutaneous bee venom in the conscious rat
19. Morphology and ultrastructure of physiologically identified substantia gelatinosa (lamina II) neurons with axons that terminate in deeper dorsal horn laminae (III-V)
20. Possible role of protein kinase C in the sensitization of primate spinothalamic tract neurons
21. NMDA-receptor-dependent synaptic plasticity: Multiple forms and mechanisms
22. Partial sciatic nerve injury in the mouse as a model of neuropathic pain: Behavioral and neuroanatomical correlates
23. Preserved acute pain and reduced neuropathic pain in mice lacking PKCγ
24. Patterns of increased brain activity indicative of pain in a rat model of peripheral mononeuropathy
25. Inflammation-induced upregulation of protein kinase Cγ immunoreactivity in rat spinal cord correlates with enhanced nociceptive processing
26. The induction of pain: An integrative review
27. Evidence for a role of protein kinase C in the sustained activation of rat dorsal horn neurons evoked by cutaneous mustard oil application
28. Functional circuitry for the induction of prolonged excitation in the rat spinal dorsal horn
29. Transmission of chronic nociception by spinal neurons expressing the substance P receptor
30. Neurophysiological characterization of the anterolateral quadrant neurons subserving pain in M. mulatta
31. Does neurogenic inflammation alter the sensitivity of unmyelinated nociceptors in the rat?
32. The effects of a non-competitive NMDA receptor antagonist, MK-801, on behavioral hyperalgesia and dorsal horn neuronal activity in rats with unilateral inflammation
33. Unsupervised waveform classification for multi-neuron recordings: A real-time, softwarebased system. I. Algorithms and implementation
34. Intrathecal N-methyl-D-aspartate induces hyperexcitability in rat dorsal horn convergent neurones
35. Tackling pain at the source: New ideas about nociceptors
36. Localization of subspecies of protein kinase C in the mammalian central nervous system
37. Cellular and subcellular distribution of NMDAR1 splice variant mRNA in the rat lumbar spinal cord
38. Involvement of glutamatergic neurotransmission and protein kinase C in spinal plasticity and the development of chronic pain
39. The cloned capsaicin receptor integrates multiple pain-producing stimuli
40. Evidence for a central component of post-injury pain hypersensitivity
41. Physiology and morphology of multireceptive neurons with C-afferent fiber inputs in the deep dorsal horn of the rat lumbar spinal cord
42. Neuronal plasticity: Increasing the gain in pain
43. Relative effectiveness of C primary afferent fibers of different origins in evoking a prolonged facilitation of the flexor reflex in the rat
44. Changes of cutaneous receptive fields of spino-cervical-tract neurones and other dorsal horn neurones by microelectrophoretically administered amino acids