Modulation of ligand selectivity by mutation of the first extracellular loop of the human C5a receptor

Biochemical Pharmacology

Volumn 61, Issue 12, 2001, Pages 1571-1579

  Cain, Stuart A ^a   Woodruff, Trent M ^b   Taylor, Stephen M ^b   Fairlie, David P ^b   Sanderson, Sam D ^c   Monk, Peter N ^a  

^a UNIVERSITY OF SHEFFIELD   (United Kingdom)

^b UNIVERSITY OF QUEENSLAND   (Australia)

^c UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

Author keywords

Antagonist; C5a; Complement; Mast cells; Receptor

Indexed keywords

COMPLEMENT COMPONENT C5A [DEARGININE]; COMPLEMENT COMPONENT C5A RECEPTOR; MUTANT PROTEIN; PEPTIDE; PHENYLALANINE [ORNITHYLPROLYL DEXTRO CYCLOHEXYLALANYLTRYPTOPHYLARGININE]; TYROSYLSERYLPHENYLALANYLLYSYLPROLYLMETHIONYLPROLYLLEUCYL DEXTRO ALANYLARGININE; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DRUG POTENCY; DRUG SELECTIVITY; HUMAN; HUMAN CELL; LEUKEMIA CELL; MAST CELL LEUKEMIA; MOLECULAR RECOGNITION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; RECEPTOR AFFINITY; SEQUENCE ANALYSIS; SPECIES DIFFERENCE;

AMINO ACID SEQUENCE; ANIMALS; ANTIGENS, CD; CELLS, CULTURED; DNA, COMPLEMENTARY; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; LIGANDS; MOLECULAR SEQUENCE DATA; MUTATION; PROTEIN CONFORMATION; RECEPTOR, ANAPHYLATOXIN C5A; RECEPTORS, COMPLEMENT; SEQUENCE HOMOLOGY, AMINO ACID; SHEEP; SWINE; TRANSFECTION;

EID: 0035877281     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-2952(01)00608-6     Document Type: Article

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