Domain closure mechanism in transferrins: New viewpoints about the hinge structure and motion as deduced from high resolution crystal structures of ovotransferrin N-lobe

Journal of Molecular Biology

Volumn 309, Issue 4, 2001, Pages 937-947

  Mizutani, Kimihiko ^a   Mikami, Bunzo ^a   Hirose, Masaaki ^a  

^a KYOTO UNIVERSITY   (Japan)

Author keywords

Domain closure; Hinge motion; Iron binding protein; Ovotransferrin; Transferrin

Indexed keywords

OVOTRANSFERRIN; TRANSFERRIN;

AMINO ACID SUBSTITUTION; ARTICLE; CONFORMATIONAL TRANSITION; CRYSTAL STRUCTURE; HYDROGEN BOND; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DOMAIN; PROTEIN STRUCTURE; STRUCTURE ANALYSIS;

EID: 0035876277     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1006/jmbi.2001.4719     Document Type: Article

References (36)

1. Location of structural domains in protein
2. Structural mechanisms for domain movements in proteins
3. Iron transport and storage proteins
4. Structure of human lactoferrin: Crystallographic structure analysis and refinement at 2.8 Å resolution
5. Three-dimensional structure of mare diferric lactoferrin at 2.6 Å resolution
6. Molecular structure of serum transferrin at 3.3 Å resolution
7. Crystal structure of diferric hen ovotransferrin at 2.4 Å resolution
8. Structure of diferric duck ovotransferrin at 2.35 resolution
9. X-ray solution scattering reveals conformational changes upon iron uptake in lactoferrin, serum and ovo-transferrins
10. Metal-induced conformational changes in transferrins
11. Tertiary structural changes and iron release from human serum transferrin
12. Crystal structure of hen apo-ovotransferrin. Both lobes adopt an open conformation upon loss of iron
13. Apolactoferrin structure demonstrates ligand-induced conformational change in transferrins
14. Ligand-induced conformational change in transferrins: Crystal structure of the open form of the N-terminal half-molecule of human transferrin
15. Two high-resolution crystal structures of the recombinant N-lobe of human transferrin reveal a structural change implicated in iron release
16. Structure of recombinant human lactoferrin expressed in Aspergillus awamori
17. Structure of human apolactoferrin at 2.0 Å resolution. Refinement and analysis of ligand-induced conformational change
18. Crystal structure at 1.9 Å resolution of the apoovotransferrin N-lobe bound by sulfate anions: Implications for the domain opening and iron release mechanism
19. Alternative structural state of transferrin. The crystallographic analysis of iron-loaded but domain-opened ovotransferrin N-lobe
20. Structural evidence for a pH-sensitive dilysine trigger in the hen ovotransferrin N-lobe: Implications for transferrin iron release
21. Domain closure in lactoferrin. Two hinges produce a see-saw motion between alternative close-packed interfaces
22. Structure of mare apolactoferrin: The N and C lobes are in the closed form
23. Structure of human diferric lactoferrin refined at 2.2-Å resolution
24. The effect of the iron saturation of transferrin on its binding and uptake by rabbit reticulocytes
25. Monoclonal antibodies to either domain of ovotransferrin block binding to transferrin receptors on chick reticulocytes
26. Association of the two lobes of ovotransferrin is a prerequisite for receptor recognition
27. Receptor recognition sites reside in both lobes of human serum transferrin
28. Asp ligand provides the trigger for closure of transferrin molecules. Direct evidence from X-ray scattering studies of site-specific mutants of the N-terminal half-molecule of human transferrin
29. The structural mechanism for iron uptake and release by transferrins
30. Structural and functional consequences of removal of the inter-domain disulfide bridge from the isolated C-lobe of ovotransferrin
31. Amino-terminal and carboxyl-terminal half-molecules of ovotransferrin: Preparation by a novel procedure and their interactions
32. Crystallization of and preliminary crystallographic data for the N-terminal half-molecule of ovotransferrin
33. Crystallographic refinement by simulated annealing: Application to crambin
34. MOLSCRIPT: A program to produce both detailed and schematic plots of protein structures
35. Raster3D - Photo-realistic molecular graphics