Transcriptional regulation of the KEL gene and Kell protein expression in erythroid and non-erythroid cells

Biochemical Journal

Volumn 356, Issue 1, 2001, Pages 171-180

  Camara Clayette, Valérie ^a   Rahuel, Cécile ^a   Lopez, Claude ^a   Hattab, Claude ^a   Verkarre, Virginie ^a   Bertrand, Olivier ^a   Cartron, Jean Pierre ^a  

^a INSTITUT NATIONAL DE LA TRANSFUSION SANGUINE   (France)

Author keywords

Blood group antigen; Tissue expression; Trans acting factor; Transcriptional activity

Indexed keywords

GENES; IMMUNOLOGY; MUTAGENESIS; PROTEINS; RNA; TISSUE;

TRANSCRIPTIONAL REGULATION;

BIOCHEMISTRY;

ANTIGEN; ANTIGEN PROTEIN KELL; CHLORAMPHENICOL ACETYLTRANSFERASE; DNA; MESSENGER RNA; UNCLASSIFIED DRUG;

ANTIGEN EXPRESSION; ARTICLE; BLOOD GROUP KELL SYSTEM; BRAIN TISSUE; CONTROLLED STUDY; DENDRITIC CELL; DNA SEQUENCE; ELECTROPHORETIC MOBILITY; ENZYMATIC ASSAY; ERYTHROID CELL; ERYTHROLEUKEMIA CELL; EXON; GENE ACTIVITY; GENE CONTROL; GENE EXPRESSION REGULATION; GENE REPRESSION; GENETIC TRANSFECTION; HELA CELL; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; LYMPHOID CELL; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PURIFICATION; SEQUENCE ANALYSIS; SERTOLI CELL; SITE DIRECTED MUTAGENESIS; SPLEEN; TESTIS; TISSUE DISTRIBUTION; TONSIL; TRANSCRIPTION REGULATION; WESTERN BLOTTING;

ANTIGENS, NUCLEAR; CHLORAMPHENICOL O-ACETYLTRANSFERASE; DNA HELICASES; DNA-BINDING PROTEINS; ERYTHROID PROGENITOR CELLS; GENE EXPRESSION REGULATION; GENES, REPORTER; HELA CELLS; HUMANS; K562 CELLS; KELL BLOOD-GROUP SYSTEM; LUCIFERASES; LYMPHOID TISSUE; MALE; NUCLEAR PROTEINS; POINT MUTATION; PROMOTER REGIONS (GENETICS); PROTEIN BINDING; TESTIS; TISSUE DISTRIBUTION; TRANSCRIPTION FACTORS;

EID: 0035874484     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/0264-6021:3560171     Document Type: Article

References (37)

1. Erythrocyte blood group antigens: Not so simple after all
2. Insights into the structure and function of membrane polypeptides carrying blood group antigens
3. Kell and Kx blood group systems
4. In vivo isosensitization of red cells in babies with haemolytic disease
5. Inhibition of erythoid progenitor cells by anti-Kell antibodies in fetal alloimmune anemia
6. Decreased fetal erythropoiesis and hemolysis in Kell hemolytic anemia
7. Time-course of polypeptides blood group antigens during human eythroid differentiation
8. The expression of human blood group antigens during erythropoiesis in a cell culture system
9. Molecular cloning and primary structure of Kell blood group protein
10. Proteolytic processing of big endothelin-3 by the Kell blood group protein
11. Association of XK and Kell blood group proteins
12. Purification and partial characterization of the erythrocyte Kx protein deficient in McLeod patients
13. The repressor which binds the -75 GATA motif of the GPB promoter contains Ku70 as the DNA binding subunit
14. Erythroid-specific activity of the glycophorin B promoter requires GATA-1 mediated displacement of a repressor
15. Organization of the gene encoding the human Kell blood group protein
16. CAT constructions with multiple unique restriction sites for the functional analysis of eukaryotic promoters and regulatory elements
17. Induction of erythroid differentiation in the human leukaemia cell line K562
18. Firefly luciferase gene: Structure and expression in mammalian cells
19. Recombinant genomes which express chloramphenicol acetyltransferase in mammalian cells
20. A rapid micropreparation technique for extraction of DNA-binding proteins from limiting numbers of mammalian cells
21. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
22. Structure of the 5′ region of the gene encoding human glycophorin A and analysis of its multiple transcripts
23. Characterization of murine monoclonal antibodies directed against the Kell blood group glycoprotein
24. Cleavage of structural proteins during assembly of the head of bacteriophage T4
25. The E-box of the human glycophorin B promoter is involved in the erythroid-specific expression of the GPB gene
26. In vitro binding of several cell-specific and ubiquitous nuclear proteins to the GT-I motif of the SV40 enhancer
27. SP1-mediated transcriptional activation is repressed by SP3
28. Different members of the SP1 multigene family exert opposite transcriptional regulation of the long terminal repeat of HIV-1
29. Sequence-specific recognition of DNA by zinc-finger peptides derived from the transcription factor SP1
30. The Ku autoantigen
31. Sp3 is a bifunctional transcription regulator with modular independent activation and repression domains
32. Sp3 encodes multiple proteins that differ in their capacity to stimulate or repress transcription
33. The human Kell blood group gene maps to chromosome 7q33 and its expression is restricted to erythropid cells
34. Basic local alignment search tool
35. Expression of Kell blood group protein in nonerythroid tissues
36. Kell is not restricted to the erythropoietic lineage but is also expressed on myeloid cells
37. Inhibition of megakaryopoiesis by Kell-related antibodies