Clinical concentrations of doxorubicin inhibit activity of myocardial membrane-associated, calcium-independent phospholipase A2

Cancer Research

Volumn 61, Issue 10, 2001, Pages 4024-4029

  McHowat, Jane ^a   Swift, Luther M ^b   Arutunyan, Ara ^b   Sarvazyan, Narine ^b  

^a SAINT LOUIS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b TEXAS TECH UNIVERSITY HEALTH SCIENCES CENTER SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DOXORUBICIN; PHOSPHOLIPASE A2;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CARDIOTOXICITY; CELL CULTURE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG BLOOD LEVEL; DRUG TISSUE LEVEL; ENZYME INHIBITION; HEART MUSCLE CELL; ISOLATED HEART; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMALS; ANTIBIOTICS, ANTINEOPLASTIC; ARACHIDONIC ACID; BLOTTING, WESTERN; CELL MEMBRANE; CYTOSOL; DITHIOTHREITOL; DOSE-RESPONSE RELATIONSHIP, DRUG; DOXORUBICIN; DRUG SYNERGISM; GLUTATHIONE; HEART; HEART VENTRICLES; MALE; MYOCARDIUM; NAPHTHALENES; PHOSPHODIESTERASE INHIBITORS; PHOSPHOLIPASES A; PYRONES; RATS; RATS, SPRAGUE-DAWLEY;

EID: 0035872490     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (33)

1. Anthracycline and anthraquinone anticancer agents: Current status and recent developments
2. Anthracyclines in the treatment of cancer
3. Adriamycin cardiomyopathy: Pathophysiology and prevention
4. Doxorubicin cardiotoxicity: Analysis of prevailing hypotheses
5. Role of the glutathione-glutathione peroxidase cycle in the cytotoxicity of the anticancer quinones
6. Inhibition of buthionine sulfoximine-enhanced doxorubicin toxicity in metallothionein overexpressing transgenic mouse heart
7. Effects of duxurubicin on cardiomyocytes with reduced level of superoxide dismutase
8. Visualization of doxorubicin-induced oxidative stress in isolated cardiac myocytes
9. Regulation and inhibition of phospholipase A2
10. Structural and dynamic effects of oxidatively modified phospholipids in unsaturated lipid membranes
11. Lipid bilayer heterogeneities and modulation of phospholipase A2 activity
12. Arachidonic acid and free fatty acids as second messengers and the role of protein kinase C
13. Cell surface actions of Adriamycin
14. Activation of phospholipase A2 by Adriamycin in vitro. Role of drug-lipid interactions
15. Adriamycin-induced changes in the surface membrane of sarcoma 180 ascites cells
16. Calcium-independent phospholipase A2 in isolated rabbit ventricular myocytes
17. Stimulation of different phospholipase A2 isoforms by TNF-α and IL-1β in adult rat ventricular myocytes
18. Thrombin activates a membrane-associated calcium-independent PLA2 in ventricular myocytes
19. Identification and characterization of human myocardial phospholipase A2 from transplant recipients suffering from end-stage ischemic heart disease
20. The genomic organization, complete mRNA sequence, cloning, and expression of a novel human intracellular membrane-associated calcium-independent phospholipase A2
21. Heart and liver membrane phospholipid homeostasis during acute administration of various antitumoral drugs to the rat
22. Protective effect of dietary selenium supplementation on delayed cardiotoxicity of Adriamycin in rat: Is PHGPX but not GPX involved?
23. Inactivation of a cytosolic phospholipase A2 by thiol-modifying reagents: Cysteine residues as potential targets of phospholipase A2
24. Structure and evolution of the lipase superfamily
25. 2. Mechanism-based discrimination between calcium-dependent and -independent phospholipases A2
26. Determinants of cardiomyocyte development in long-term primary culture
27. Mammalian calcium-independent phospholipase A2
28. Binding of Adriamycin to liposomes as a probe for membrane lateral organization
29. Interaction with protein SH groups could be involved in Adriamycin cardiotoxicity
30. Thiol oxidation and inhibition of Ca-ATPase by Adriamycin in rabbit heart microsomes
31. Tissue-specific functions of individual glutathione peroxidases
32. Protective action of phospholipid hydroperoxide glutathione peroxidase against membrane-damaging lipid peroxidation. In situ reduction of phospholipid and cholesterol hydroperoxides
33. Tissue-specific regulation of selenoenzyme gene expression during selenium deficiency in rats