Nerve fibers innervating the cranial and spinal meninges: Morphology of nerve fiber terminals and their structural integration

Microscopy Research and Technique

Volumn 53, Issue 2, 2001, Pages 96-105

  Fricke, Britta ^a   Andres, Karl Hermann ^a   Von Düring, Monika ^a  

^a RUHR UNIVERSITY BOCHUM   (Germany)

Author keywords

Cerebral arteries; Cerebrospinal fluid; Chemoreceptors; Dura mater; Innervation; Leptomeninx; Mechanoreceptors; Pia mater; Post puncture headache; Subarachnoid space

Indexed keywords

BRAIN; CEREBROSPINAL FLUID; FIBERS; TEXTURES;

CEREBRAL ARTERIES; DURA MATER; INNERVATION; LEPTOMENINX; MECHANORECEPTORS; NERVE FIBERS; NERVE TERMINALS; PIA MATERS; POST PUNCTURE HEADACHE; SUBARACHNOID SPACES;

CHEMOSENSOR;

ARTICLE; BRAIN ARTERY; CEREBROSPINAL FLUID ANALYSIS; CHEMORECEPTOR; CRANIAL NERVE; DURA MATER; HUMAN; INNERVATION; LEPTOMENINX; MECHANORECEPTOR; NERVE CONDUCTION; NONHUMAN; PRIORITY JOURNAL; SPINAL NERVE; SUBARACHNOID SPACE;

EID: 0035871117     PISSN: 1059910X     EISSN: None     Source Type: Journal    
DOI: 10.1002/jemt.1074     Document Type: Article

References (121)

1. Andres KH. 1967a. Über die Feinstruktur der Arachnoidea und Dura mater von Mammalia. Z Zellforsch 79:272-295.
2. Andres KH. 1967b. Zur Feinstruktur der Arachnoidalzotten bei Mammalia. Z Zellforsch 82:92-109.
3. Andres KH, Düring M von. 1973. Morphology of cutaneous receptors. In: Iggo A, editor. Handbook of sensory physiology Vol. II. New York: Springer, p 3-28.
4. Andres KH, Düring M von, Schmidt RF. 1985. Sensory innervation of the Achilles tendon by group III and IV afferent fibers. Anat Embryol 172:145-156.
5. Andres KH, Düring M von, Muszynski K, Schmidt RF. 1987a. Nerve fibres and their terminals of the dura mater encephali of the rat. Anat Embryol 175:289-301.
6. Andres KH, Düring M von, Muszynski K, Schmidt RF. 1987b. The innervation of the dura mater encephali of the rat. In: Schmidt RF, Schaible HG, Vahle-Hinz C, editors. Fine afferent nerve fibers and pain. Weinheim, Germany: VCH. p 15-25.
7. Arbab MAR, Wiklund L, Svengaard NA. 1986. Origin and distribution of cerebral vascular innervation from superior cervical, trigeminal and spinal ganglia investigated with retrograde and anterograde WGA-HRP tracing in the rat. Neuroscience 19:695-708.
8. Artico M, De Santis S, Cavallotti C. 1998. Cerebral dura mater and cephalalgia: relationships between mast cells and catecholaminergic nerve fibers in the rat. Cephalalgia 18:183-191.
9. Bauersachs M. 1991. Immuncytochemische Darstellung über die Innervation der Dura mater encephali der Ratte. Thesis, Ruhr-University, Bochum, Germany
10. Bleys RL, Cowen T, Groen GJ, Hillen B, Ibrahim NB. 1996a. Perivascular nerves of the human basal arteries: I. Topographical distribution. J Cereb Blood Flow Metab 16:1034-1047.
11. Bleys RL, Cowen T, Groen GJ, Hillen B. 1996b. Perivascular nerves of the human basal arteries: II. Changes in aging and Alzheimer's disease. J Cereb Blood Flow Metab 16:1048-1057.
12. Braun JS, Kaissling B, Hir ML, Zenker W. 1993. Cellular components of the immune barrier in the spinal meninges and dorsal root ganglia of the normal rat: immunohistochemical (MHC class II) and electron-microscopic observations. Cell Tissue Res 273:209-217.
13. Brinker T, Ludemann W, Berens von Rautenfeld D, Samii M. 1997. Dynamic properties of lymphatic pathways for the absorption of cerebrospinal fluid. Acta Neuropathol (Berl) 94:493-498.
14. Busch E. 1938. The innervation of the intracranial blood-vessels. Acta Psychiatr Neurol 13:131-138.
15. Buzzi MG, Moskowitz MA. 1990. The antimigraine drug, sumatriptan (GR43175), selectively blocks neurogenic plasma extravasation from blood vessels in dura mater. Br J Pharmacol 99:202-206.
16. Cavallotti D, Artico M, De Santis S, Iannetti G, Cavallotti C. 1998. Catecholaminergic innervation of the human dura mater involved in headache. Headache 38:352-355.
17. Chambers MR, Andres KH, Düring M von, Iggo A. 1972. Structure and function of the slowly adapting type II mechanoreceptor in hairy skin. Q J Exp Physiol 57:417-445
18. Chang JY, Hardebo JE, Owman C, Sahlin C, Svengaard N-A. 1987. Nerves containing serotonin, its interaction with noradrenaline, and characterization of serotonin receptors in cerebral arteries of monkey. J Auton Pharmacol 7:317-329.
19. Chan-Palay V. 1976. Serotonin axons in the supra- and subependymal plexus and in the leptomeninges; their roles in local alterations of cerebrospinal fluid and vasomotor activity. Brain Res 102:103-130.
20. Clark SM. 1931. Innervation of the pia mater of the spinal cord and medulla. J Comp Neurol 53:129-141.
21. Dahl E. 1973. The innervation of the cerebral arteries. J Anat 115: 53-63.
22. Dahl E, Flora G, Nelson E. 1965. Electron microscopic observations on normal human intracranial arteries. Neurology 15:132-140.
23. Dimitriadou V, Buzzi MG, Moskowitz MA, Theoharides TC. 1991. Trigeminal sensory fiber stimulation induces morphological changes reflecting secretion in rat dura mater mast cells. Neuroscience 44:97-112.
24. Dimitriadou V, Buzzi MG, Theoharides TC, Moskowitz MA. 1992. Ultrastructural evidence for neurogenically mediated changes in blood vessels of the rat dura mater and tongue following antidromic trigeminal stimulation. Neuroscience 48:187-203.
25. Dimitriadou V, Rouleau A, Trung Tuong MD, Newlands GJF, Miller HRP, Luffau G, Schwartz J-C, Garbarg M. 1997. Functional relationships between sensory nerve fibers and mast cells of dura mater in normal and inflammatory conditions. Neuroscience 77:829-839.
26. Drummond HA, Price MP, Welsh MJ, Abboud FM. 1998. A molecular component of the arterial baroreceptor mechanotransduction. Neuron 21:1435-1441.
27. Düring M von, Andres KH. 1991. Sensory nerve fiber terminals in the arachnoid granulations of non-human primates. Neurosci Lett 127: 121-124.
28. Düring M von, Andres KH. 1995. Topography and pattern of peptidergic nerve fibers in the dura mater of non-human primates. Pain in Europe 1995. European Federation of IASP Chapters, Abstract Book, p. 76.
29. Düring M von, Bauersachs M, Böhmer B, Veh RW, Andres KH. 1990. Neuropeptide Y- and substance P-like immunoreactive nerve fibers in the rat dura mater encephali. Anat Embryol 182:363-373.
30. Ebersberger A, Ringkamp M, Reeh PW, Handwerker HO. 1997. Recordings from the brain stem neurons responding to chemical stimulation of the subarachnoid space. J Neurophysiol 77:3122-3133.
31. Edvinsson L, Uddman R. 1982. Immunohistochemical localization and dilatatory effect of substance P on human cerebral vessels. Brain Res 232:466-471.
32. Edvinsson L, Nielsen KC, Owman CH, West KA. 1974. Adrenergic innervation of the mammalian choroid plexus. Am J Anat 139:299-308.
33. Edvinsson L, Hakanson R, Lindvall M, Owman Ch, Svensson KG. 1975. Ultrastructural and biochemical evidence for a sympathetic neural influence on the choroid plexus. Exp Neurol 48:241-251.
34. Edvinsson L, McCulloch J, Uddman R. 1981. Substance P: Immunocytochemical localization and effect upon cat pial arteries in vitro and in situ. J Physiol 318:251-258.
35. Edvinsson L, Degueurce A, Duverger D, MacKenzie ET, Scatton B. 1983. Central serotoninergic nerves project to the pial vessels of the brain. Nature 306:55-57.
36. Edvinsson L, Gulbenkian S, Barroso CP, Cunha S, Polak JM, Mortensen A, Jorgensen L, Jansen-Olesen I. 1998. Innervation of the human middle meningeal artery: immunohistochemistry, ultrastructure, and role of endothelium for vasomotility. Peptides 19: 1213-1225.
37. Erlich SS, McComb JG, Hyman S, Weiss MH. 1989. Ultrastructure of the orbital pathway for cerebrospinal fluid drainage in rabbits. J Neurosurg 70:926-931.
38. Escott KJ, Connor HE, Brain SD, Beattie DT. 1995. The involvement of calcitonin gene-related peptide (CGRP) and substance P in feline pial artery diameter responses evoked by capsaicin. Neuropeptides 29:129-135.
39. Ferrante F, Ricci A, Felici L, Cavallotti C, Amenta F. 1990. Suggestive evidence for a functional association between mast cells and sympathetic nerves in meningeal membranes. Acta Histochem Cytochem 23:637-646.
40. Fricke B, Düring M von, Andres KH. 1997. Topography and immunocytochemical characterization of nerve fibers in the leptomeningeal compartments of the rat. A light-and electron-microscopical study. Cell Tissue Res 287:11-22.
41. Fricke B, Lints R, Stewart G, Drummond H, Dodt G, Driscoll M, Düring M von. 2000. Epithelial Na+ channels and stomatin are expressed in rat trigeminal mechanosensory neurons. Cell Tissue Res 299:327-334.
42. Gomez DG, Manzo RP, Fenstermacher JD, Potts DG. 1988. Cerebrospinal fluid absorption in the rabbit. Graef's Arch Clin Exp Ophthalmol 226:1-7.
43. Gerrits RJ, Raczynski C, Greene AS, Stein EA. 2000. Regional cerebral blood flow responses to variable frequency whisker stimulation: an autoradiographic analysis. Brain Res 864:205-212.
44. Griffith SG, Lincoln J, Burnstock G. 1982. Serotonin as a neurotransmitter in cerebral arteries. Brain Res 247:388-392.
45. Groen GJ, Baljet B, Drukker J. 1988. The innervation of the spinal dura mater: Anatomy and clinical implications. Acta Neurochir (Wien) 92:39-46.
46. Gulland GL. 1898. The occurence of nerves on intracranial blood vessels. Br Med J 2:781-782.
47. Hammersen F. 1963. Die Angioarchitektonik der Dura mater encephali. I. Zur Problematik der sogenannten Mäander-Gefässe und Knäuelarterien. Z Zellforsch 59:153-164
48. Hanko J, Hardebo JE, Kahrström J, Owman C, Sundler F. 1985. Calcitonin gene-related peptide is present in mammalian cerebrovascular nerve fibers and dilates pial and peripheral arteries. Neurosci Lett 57:91-95.
49. Hara H, Kobayashi S. 1987. Vasoactive intestinal polypeptide (VIP)-like immunoreactive cells in the skull base of the rat. Histochemistry 87:217-221.
50. Hashimoto PH, Gotow T, Ichimura T, Nakatani T, Takasu N, Kodaka R, Sumitani S, Fukuda T. 1985. Visualization of the cerebrospinal fluid drainage into the Galen's Vein. Arch Hist Jpn 48:173-181.
51. Hedge SA, Hara H, Kobayashi S. 1988. Innervation of radicular and extraparenchymal arteries of spinal cord. Histochemical and immunohistochemical study in primate. Histochemistry 89:415-420.
52. Huber GC. 1897. Observations on the innervation of the intracranial vessels. J Comp Neurol 9:1-25.
53. Iggo A, Andres KH. 1982. Morphology of cutaneous receptors. Ann Rev Neurosci 5:1-31
54. Iggo A, Gottschald K-M. 1974. Cutaneous mechanoreceptors in simple and in complex sensory structures. In: Schwartzkopff J, editor. Mechanoreception. Opladen: Westdeutscher Verlag. p 153-176.
55. Johanson CE. 1995. Ventricles and cerebrospinal fluid. In: Conn PM, editor. Neuroscience in medicine. Philadelphia: J.B. Lippincott Company. p 171-196.
56. Kautzky R. 1951. Grundlagen der cerebrospinalen Innervation der Hirnhäute und Hirngefässe. Z Anat Entw Gesch 115:570-583.
57. Keller JT, Saunders MC, Beduk A, Jollis JG. 1985. Innervation of the posterior fossa dura of the cat. Brain Res Bull 14: 97-102.
58. Keller JT, Marfurt CF, Dimlich RVW, Tierney BE. 1989. Sympathetic innervation of the supratentorial dura mater of the rat. J Comp Neurol 290:310-321.
59. Kerber CW, Newton TH. 1973. The macro- and microvasculature of the dura mater. Neuroradiology 6:175-179.
60. Knyihár-Csillik E, Tajti J, Samsara M, Sáry G, Slezák S, Vécsei L. 1997. Effect of a serotonin agonist (sumatriptan) on the peptidergic innervation of the rat cerebral dura mater and on the expression of c-fos in the caudal trigeminal nucleus in an experimental migraine model. J Neurosci Res 48:449-464.
61. Konnai Y, Honda T, Sekiguchi Y, Kikuchi S, Sugiura Y. 2000. Sensory innervation of the lumbar dura mater passing through the sympathetic trunk in rats. Spine 25:776-782
62. Krahn V. 1983. Nerve sheaths in the leptomeningeal connective tissue. Acta Anat 116:84-89.
63. Krisch B. 1988. Ultrastructure of the meninges at the site of penetration of veins through the dura mater, with particular reference to Pacchionian granulations. Investigations in the rat and two species of New-World monkeys (Cebus apella, Callitrix jacchus). Cell Tissue Res 251:621-631.
64. Krisch B, Leonhardt H, Oksche A. 1984. Compartments and perivascular arrangement of the meninges covering the cerebral cortex of the rat. Cell Tissue Res 238:459-474.
65. Kumar R, Berger RJ, Dunsker SB, Keller JT. 1996. Innervation of the spinal dura. Myth or reality? Spine 21:18-26.
66. Lang J. 1971. Zur Vaskularisation der Dura mater cerebri. Z Anat Entwickl Gesch 135:20-34.
67. Lang J. 1985. Die Anatomie der BWS und des benachbarten Nervensystems. In: Hohmann D, Kügelgen B, Liebig, K, editors. Neuroorthopädie 3. Berlin: Springer, p 14-73.
68. Lasater GM. 1970. Primary intracranial hypotension. The low spinal fluid pressure syndrome. Headache 10:63-66.
69. Levine JE, Povlishock JT, Becker DP. 1982. The morphological correlates of primate cerebrospinal fluid absorption. Brain Res 241:31-41.
70. Lindvall M, Owman C. 1981. Autonomic nerves in the mammalian choroid plexus and their influence on the formation of cerebrospinal fluid. J Cereb Blood Flow Metab 1(3):245-266.
71. Lindvall M, Alumets J, Edvinsson L, Fahrenkrug J, Hakanson R, Hanko J, Owman Ch, Schaffalitzky de Muckadell OB, Sundler F. 1978a. Peptidergic (VIP) nerves in the mammalian choroid plexus. Neurosci Lett 9:77-82.
72. Lindvall M, Edvinsson L, Owman Ch. 1978b. Sympathetic nervous control of cerebrospinal fluid production from the choroid plexus. Adv Neurol 20:111-120.
73. Loewenstein WR, Skalak R. 1966. Mechanical transmission in a Pacinian corpuscle. J Physiol (Lond) 182:346-378.
74. Malinovsky L, Pac L. 1982. Morphology of sensory corpuscles in mammals. Acta Facultatis Medicae Universitatis Brunenis.
75. Markowitz S, Saito K, Moskowitz MA. 1987. Neurogenically mediated leakage of plasma protein occurs from blood vessels in dura mater but not brain. J Neurosci 7:4129-4136.
76. Mayberg M, Langer RS, Zervas NT, Moskowitz MA. 1981. Perivascular meningeal projections from cat trigeminal ganglia: Possible pathway for vascular headaches in man. Science 213:228-230.
77. Mayberg MR, Zervas NT, Moskowitz MA. 1984. Trigeminal projections to supratentorial pial and durai blood vessels in cats demonstrated by horseradish peroxidase histochemistry. J Comp Neurol 223:46-56.
78. McCulloch J, Uddman R, Kingman TA, Edvinsson L. 1986. Calcitonin gene-related peptide: functional role in cerebrovascular regulation. Proc Natl Acad Sci USA 83:5731-5735.
79. McNaughton FL. 1937. The innervation of the intracranial blood vessels and durai sinuses. Res Nerv Ment Dis Proc 18:178-200.
80. Messlinger K, Hanesch U. 1995. Calcitonin gene-related peptide immunreactive Nervenfasern in der Dura mater encephali der Ratte. Experimente zur neurogenen Entzündung der Hirnhäute. Der Schmerz 9:20-28.
81. Messlinger K, Hanesch U, Baumgärtel M, Trost B, Schmidt RF. 1993. Innervation of the dura mater encephali of cat and rat: ultrastructure and calcitonin gene-related peptide-like and substance P-like immunoreactivity. Anat Embryol 188:219-237.
82. Miura M, Kato S, von Ludinghausen M. 1998. Lymphatic drainage of the cerebrospinal fluid from monkey spinal meninges with special reference to the distribution of the epidural lymphatics. Arch Histol Cytol 61:277-286.
83. Moskowitz M. 1992. Neurogenic versus vascular mechanisms of sumatriptan and ergot alkaloids in migraine. TIPS 13:307-311.
84. Nakamura S, Milhorat TH. 1978. Nerve endings in the choroid plexus of the fourth ventricle of the rat: electron microscopic study. Brain Res 153:285-293.
85. Nelson E, Rennels M. 1970a. Innervation of intracranial arteries. Brain 93:475-490.
86. Nelson E, Rennels M. 1970b. Neuromuscular contacts in intracranial arteries of the cat. Science 167:301-302.
87. Nielson KC, Owman C, Sporrong B. 1971. Ultrastructure of the autonomic innervation apparatus in the main pial arteries of rats and cats. Brain Res 27:25-32.
88. Nielson KC, Lindvall-Axelsson M, Owman C. 1992. Neuroendocrine regulatory mechanisms in the choroid plexus-cerebrospinal fluid system. Brain Res Rev 17:109-138.
89. Nozaki K, Boccalini P, Moskowitz MA. 1992a. Expression of c-fos-like immunoreactivity in brain stem after meningeal irritation by blood in the subarachnoid space. Neuroscience 49:669-680.
90. Nozaki K, Moskowitz MA, Boccalini P. 1992b. CP-93,129, sumatriptan, dihydroergotamine block c-fos expression within rat trigeminal nucleus caudalis caused by chemical stimulation of the meninges. Br J Pharmacol 106:409-415.
91. Obersteiner H. 1897. Die Innervation der Hirngefässe. Arbeiten aus dem Institut für Anatomie und Physiologie des Zentralnervensystems and der Wiener Universität 5:78.
92. O'Connor T, van der Kooy D. 1986. Pattern of intracranial and extracranial projections of trigeminal ganglion cells. J Neurosci 6:2200-2207.
93. Ottoson A, Edvinsson L. 1997. Release of histamine from dural mast cells by substance P and calcitonin-related peptide. Cephalalgia 17:166-174.
94. Parke WW, Watanabe R. 1989. Adhesions of the ventral lumbar dura. An adjunct source of discogenic pain? Spine 15:300-303.
95. Parkinson D. 1991. Human spinal arachnoid septa, trabeculae, and "rogue strands". Am J Anat 192:498-509.
96. Patin DJ, Eckstein EC, Harum K, Pallares VS. 1993. Anatomic and biochemical properties of human lumbar dura mater. Anesth Analg 76:535-540.
97. Pease DC, Molinari S. 1960. Electron microscopy of muscular arteries; pial vessels of the cat and monkey. J Ultrastruct Res 3:447-468.
98. Rando TA, Fishmann RA. 1992. Spontaneous intracranial hypotension: report of two cases and review of literature. Neurology 42:481-487.
99. Reivich M. 1974. Blood flow metabolism couple in brain. Res Publ Assoc Nerv Ment Dis 53:125-140.
100. Risling M, Dalsgaard C-J, Frisén J, Sjögren A-M, Fried K. 1994. Substance P-, calcitonin gene-related peptide, growth-associated protein-43, and neurotrophin receptor-like immunoreactivity associated with unmyelinated axons in feline ventral roots and pia mater. J Comp Neurol 339:365-386.
101. Rozniecki JJ, Dimitriadou V, Lambracht-Hall M, Pang X, Theoharides TC. 1999. Morphological and functional demonstration of dura mater mast cell-neuron interactions in vitro and in vivo. Brain Res 849:1-15.
102. Samarasinghe DD. 1965. The innervation of the cerebral arteries in the rat: an electron microscope study. J Anat 99:815-828.
103. Sato S. 1966. An electron microscopic study on the innervation of the intracranial artery of the rat. Am J Anat 118:873-890.
104. Scapinelli R. 1990. Anatomical and radiologic studies on the lumbosacral meningovertebral ligaments of humans. J Spinal Disord 3:6-15.
105. Steiger HJ, Tew JM, Keller JT. 1982. The sensory representation of the trigeminal ganglion of the cat. Neurosci Lett 31:231-236.
106. Stohr Ph jr. 1940. Über den Bau sensibler Nervenendigungen in der Pia mater des Menschen. Z Zellforsch Mikrosk Anat 30:78-97.
107. Suzuki N, Hardebo JE, Owman Ch. 1988. Origin and pathways of cerebrovascular vasoactive interstinal polypeptide-positive nerves in rat. J Cereb Blood Flow Metab 8:697-712.
108. Szmydynger-Chodobska J, Monfils PR, Lin AY, Rahman MP, Johanson CE, Chodobski A. 1996. NADPH-diaphorase histochemistry of rat choroid plexus blood vessels and epithelium. Neurosci Lett 208:179-182.
109. Theoharides TC, Spanos C, Pang X, Alferes L, Ligris K, Letourneau R, Rozniecki JJ, Webster E, Chrousos GP. 1995. Stress-induced intracranial mast cell degranulation: a corticotropin-releasing hormone-mediated effect. Endocrinology 136:5745-5750.
110. Tripathi BJ, Tripathi RC. 1974. Vacuolar transcellular channels as a drainage pathway for cerebrospinal fluid. J Physiol 239:195-206.
111. Tsai S-H, Tew JM, Shipley MT. 1989. Cerebral arterial innervation: II. Development of calcitonin-gene-related peptide and norepinephrine in the rat. J Comp Neurol 279:1-12.
112. Upton ML, Weller RO, Path FRC. 1985. The morphology of cerebrospinal fluid drainage pathways in human arachnoid granulations. J Neurosurg 63:867-875.
113. Uddman R, Hara H, Edvinsson L. 1989. Neuronal pathways to the rat middle meningeal artery revealed by retrograde tracing and immunocytochemistry. J Auton Nerv Syst 26:69-75.
114. Williamson DJ, Hargreaves RJ, Hill RG, Shepheard SL. 1997. Sumatriptan inhibits neurogenic vasodilatation in the anaesthetized rat: intravital microscope studies. Cephalalgia 17:525-531.
115. Witzig K. 1940. Beitrag zur Frage der funktionellen Struktur der Dura mater cerebri des Menschen. Jahr Naturforsch Ges Zürich 85:71-97.
116. Wright PM, Nogueira GJ, Levin E. 1971. Role of the pia mater in the transfer of substances in and out of the cerebrospinal fluid. Exp Brain Res 13:294-305.
117. Yu X-J, Cutrer FM, Moskowitz MA, Waeber C. 1997. The 5-HT1D receptor antagonist GR-127,935 prevents inhibitory effects of sumatriptan but not CP-122,288 and 5-CT on neurogenic plasma extravasation within guinea pig dura mater. Neuropharmacology 36:83-91.
118. Yamada H, Honda T, Kikuchi S, Sugiura Y. 1998. Direct innervation of sensory fibers from the dorsal root ganglion of the cervical dura mater of rats. Spine 23:1524-1529.
119. Yamashima T. 1986. Ultrastructural study of the final cerebrospinal fluid pathway in human arachnoid villi. Brain Res 384:68-76.
120. Zenker W, Bankoul S, Braun JB. 1994. Morphological indications for considerable diffuse reabsorption of cerebrospinal fluid in spinal meninges particularly in the areas of meningeal funnels. Anat Embryol 189:243-258.
121. Zoli M, Jansson A, Sykova E, Agnati LF, Fuxe K. 1999. Volume transmission in the CNS and its relevance for neuropsychopharmacology. TIPS 20:142-150.