Pharmacokinetic properties of a novel tissue-type plasminogen activator pamiteplase after single intravenous administration to rats, dogs, and monkeys

Thrombosis Research

Volumn 101, Issue 6, 2001, Pages 493-500

  Oikawa, Keishi ^a,b   Kamimura, Hidetaka ^a   Watanabe, Takashi ^a   Miyamoto, Ikuo ^a   Higuchi, Saburo ^a  

^a ASTELLAS PHARMA INC   (Japan)

^b 1 8 Azusawa 1 Chome Itabashi ku ^*  (Japan)

Author keywords

Dog; Monkey; Pamiteplase; Pharmacokinetics; Rat; t PA

Indexed keywords

ALTEPLASE; PAMITEPLASE;

ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; BODY WEIGHT; CONTROLLED STUDY; DOG; DOSE TIME EFFECT RELATION; DRUG ACTIVITY; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG HALF LIFE; DRUG INDUCED DISEASE; DRUG INFUSION; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; MALE; MONKEY; NONHUMAN; PRIORITY JOURNAL; RAT; SPECIES DIFFERENCE; THROMBOSIS;

ANIMALS; AREA UNDER CURVE; BODY WEIGHT; DOGS; ENZYME-LINKED IMMUNOSORBENT ASSAY; HALF-LIFE; HAPLORHINI; INJECTIONS, INTRAVENOUS; MALE; METABOLIC CLEARANCE RATE; RATS; RATS, INBRED F344; RECOMBINANT PROTEINS; TISSUE PLASMINOGEN ACTIVATOR;

EID: 0035868254     PISSN: 00493848     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0049-3848(00)00414-X     Document Type: Article

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