A chiroselective peptide replicator

Nature

Volumn 409, Issue 6822, 2001, Pages 797-801

  Saghatellan, A ^a   Yokobayashi, Y ^a   Soltani, K ^a   Ghadiri, M R ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOPOLYMER; POLYPEPTIDE;

AMINO ACID SEQUENCE; ARTICLE; CATALYSIS; CHEMICAL REACTION; CHIRALITY; PEPTIDE ANALYSIS; PRIORITY JOURNAL; REACTION ANALYSIS; STEREOCHEMISTRY;

NASA DISCIPLINE EXOBIOLOGY; NON-NASA CENTER;

AMINO ACID SEQUENCE; CATALYSIS; EVOLUTION, CHEMICAL; MOLECULAR SEQUENCE DATA; MUTATION; PEPTIDE BIOSYNTHESIS; PEPTIDE FRAGMENTS; PEPTIDES; PROTEIN CONFORMATION; STEREOISOMERISM; THERMODYNAMICS;

EID: 0035865080     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/35057238     Document Type: Article

References (27)

1. The origin and amplification of biomolecular chirality
2. Origins of homochirality
3. Experiments on the abiotic amplification of optical activity
4. Enantiomeric excesses in meteoritic amino acids
5. Weak neutral currents and the origin of biomolecular chirality
6. Chiral symmetry breaking in sodium chlorate crystallization
7. Spontaneous generation and amplification of optical activity in alpha-amino acids by enantioselective occlusion into centrosymmetric crystals of glycine
8. On spontaneous asymmetric synthesis
9. Nonlinear effects in asymmetric synthesis and stereoselective reactions: Ten years of investigation
10. Asymmetric autocatalysis and amplification of enantiomeric excess of a chiral molecule
11. Homochiral imperative of molecular evolution
12. Pyranosyl-RNA: Chiroselective self-assembly of base sequences by ligative oligomerization of tetranucleotide-2′,3′-cydophosphates (with a commentary concerning the origin of biomolecular homochirality)
13. Chiral selection in poly(C)-directed synthesis of oligo(G)
14. Enantiomeric cross-inhibition in the synthesis of oligonucleotides on a nonchiral template
15. A highly enantio-selective hexitol nucleic acid template for nonenzymic oligoguanylate synthesis
16. A self-replicating peptide
17. Peptide self-replication via template-directed ligation
18. Emergence of symbiosis in peptide selfreplication through a hypercyclic network
19. Dynamic error correction in autocatalytic peptide networks
20. Influence of secondary structure (helical conformation) on stereoselectivity in peptide couplings
21. Stereoselection in designed three-helix bundle metalloproteins
22. A switch between two-, three-, and four-stranded coiled coils in GCN4 leucine zipper mutants
23. The helix-destabilizing propensity scale of Damino acids: The influence of side chain steric effects
24. Structure effects of double D-amino acid replacements: A nuclear magnetic resonance and circular dichroism study using amphipathic model helixes
25. Peptide destabilization by two adjacent D-amino acids in single-stranded amphipathic alpha-helixes
26. Synthesis of proteins by native chemical ligation