CD9 amino acids critical for upregulation of diphtheria toxin binding

Biochemical and Biophysical Research Communications

Volumn 289, Issue 4, 2001, Pages 782-790

  Hasuwa, Hidetoshi ^a,b   Shishido, Yuji ^a   Yamazaki, Ayano ^b   Kobayashi, Terukazu ^a   Yu, Xiaochun ^a,b   Mekada, Eisuke ^b  

^a KURUME UNIVERSITY   (Japan)

^b OSAKA UNIVERSITY   (Japan)

Author keywords

Diphtheria toxin; HB EGF; Tetraspanin

Indexed keywords

CD9 ANTIGEN; DIPHTHERIA TOXIN; EPIDERMAL GROWTH FACTOR; TETRASPANIN;

AMINO ACID SEQUENCE; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; MOLECULAR RECOGNITION; MONKEY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN PROTEIN INTERACTION; PROTEIN SYNTHESIS INHIBITION; SEQUENCE HOMOLOGY; STRUCTURE ACTIVITY RELATION;

EID: 0035861966     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1006/bbrc.2001.6053     Document Type: Article

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7. Heparin-binding EGF-like growth factor, which acts as the diphtheria toxin receptor, forms a complex with membrane protein DRAP27/CD9, which up-regulates functional receptors and diphtheria toxin sensitivity
8. A metalloprotease-disintegrin MDC9/Meltrin-γ/ADAM9, and PKCδ are involved in TPA-induced ectodomain shedding of membrane-anchored heparin-binding EGF-like growth factor
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11. A dual signaling cascade that regulates the ectodomain shedding of HB-EGF
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14. Membrane anchored heparin-binding EGF-like growth factor and DRAP27/CD9 form a complex with integrin α3β1 at cell-cell contact sites
15. Heparin-like molecules on the cell surface potentiate binding of diphtheria toxin to the diphtheria toxin receptor/membrane-anchored heparin-binding EGF-like growth factor
16. An antibody that inhibits the binding of diphtheria toxin to cells, revealed the association of a 27-kDa membrane protein with the diphtheria toxin receptor
17. The 27-kD diphtheria toxin receptor-associated protein (DRAP27) from Vero cells is the monkey homologue of human CD9 antigen: Expression of DRAP27 elevates the number of diphtheria toxin receptors on toxin-sensitive cells
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20. Domain analysis of the tetraspanins: Studies of CD9/CD63 chimeric molecules on subcellular localization and upregulation activity for diphtheria toxin binding
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26. The membrane protein CD9/DRAP27 potentiates the growth factor activity of the membrane-anchored heparin-binding EGF-like growth factor (HB-EGF)
27. An anti-CD9 monoclonal antibody promotes adhesion and induces proliferation of Schwann cells in vitro
28. CD9 plays a role in Schwann cell migration in vitro
29. CD9-regulated adhesion. Anti-CD9 monoclonal antibody induce pre-B cell adhesion to bone marrow fibroblasts through de novo recognition of fibronectin
30. Ectopic expression of human and feline CD9 in a human B cell line confers beta 1 integrin-dependent motility on fibronectin and laminin substrates and enhanced tyrosine phosphorylation
31. CD9 of mouse brain is implicated in neurite outgrowth and cell migration in vitro and is associated with the alpha 6/beta 1 integrin and the neural adhesion molecule L1
32. Suppression of cell motility and metastasis by transfection with human motility-related protein (MRP-1/CD9) DNA
33. Identification of the motility-related protein (MRP-1), recognized by monoclonal antibody M31-15, which inhibits cell motility
34. Expression of the neuroglandular antigen and analogues in melanoma. CD9 expression appears inversely related to metastatic potential of melanoma
35. Role of transmembrane 4 superfamily (TM4SF) proteins CD9 and CD81 in muscle cell fusion and myotube maintenance
36. CD9, a major platelet cell surface glycoprotein, is a ROCA antigen and is expressed in the nervous system
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38. Expression and distribution of CD9 in myelin of the central and peripheral nervous systems
39. Immune system-related CD9 is expressed in mouse central nervous system myelin at a very late stage of myelination
40. Requirement of CD9 on the egg plasma membrane for fertilization
41. Severely reduced female fertility in CD9-deficient mice
42. The gamete fusion process is defective in eggs of Cd9-deficient mice
43. CD9, a tetraspan transmembrane protein, renders cells susceptible to canine distemper virus
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45. The tetraspanin superfamily: Molecular facilitators
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48. Binding of hepatitis C virus E2 glycoprotein to CD81 does not correlate with species permissiveness to infection