High pressure refolding of recombinant human growth hormone from insoluble aggregates: Structural transformations, kinetic barriers, and energetics

Journal of Biological Chemistry

Volumn 276, Issue 50, 2001, Pages 46856-46863

  St John, Richard J ^a   Carpenter, John F ^b   Balny, Claude ^c   Randolph, Theodore W ^a  

^a UCB 450   (United States)

^b UNIVERSITY OF COLORADO   (United States)

^c INSERM   (France)

Author keywords

[No Author keywords available]

Indexed keywords

GROWTH KINETICS; HYDROCHLORIC ACID; HYDROGEN BONDS; HYDROSTATIC PRESSURE; SPECTROSCOPIC ANALYSIS; THERMAL EFFECTS; UREA;

ELECTROSTATIC INTERACTIONS;

HORMONES;

CHAOTROPIC AGENT; GUANIDINE; PROTEIN; RECOMBINANT GROWTH HORMONE; UNCLASSIFIED DRUG; UREA; HUMAN GROWTH HORMONE; RECOMBINANT PROTEIN;

AGITATION; ARTICLE; BINDING KINETICS; CELL TRANSFORMATION; CONCENTRATION RESPONSE; ELECTRICITY; ENERGY; HIGH TEMPERATURE PROCEDURES; HORMONE BINDING; HUMAN; HUMAN CELL; HYDROGEN BOND; HYDROSTATIC PRESSURE; MOLECULAR DYNAMICS; PRESSURE MEASUREMENT; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN ANALYSIS; PROTEIN FOLDING; PROTEIN SECONDARY STRUCTURE; PROTEIN STRUCTURE; STRUCTURE ANALYSIS; TEMPERATURE DEPENDENCE; THERMODYNAMICS; ULTRAVIOLET SPECTROSCOPY; CHEMISTRY; DOSE RESPONSE; INFRARED SPECTROSCOPY; KINETICS; METABOLISM; PRESSURE; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN DENATURATION; SPECTROPHOTOMETRY; TEMPERATURE; TIME; ULTRAVIOLET RADIATION;

DOSE-RESPONSE RELATIONSHIP, DRUG; GUANIDINE; HUMAN; HUMAN GROWTH HORMONE; KINETICS; PRESSURE; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN DENATURATION; PROTEIN FOLDING; PROTEIN STRUCTURE, SECONDARY; RECOMBINANT PROTEINS; SPECTROPHOTOMETRY; SPECTROSCOPY, FOURIER TRANSFORM INFRARED; TEMPERATURE; THERMODYNAMICS; TIME FACTORS; ULTRAVIOLET RAYS; UREA;

EID: 0035861633     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M107671200     Document Type: Article

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