Effect of E3040, an inhibitor of 5-lipoxygenase and thromboxane synthase, on rat bowel damage induced by lipopolysaccharide

European Journal of Pharmacology

Volumn 427, Issue 2, 2001, Pages 159-166

  Oketani, Kiyoshi ^a   Inoue, Takashi ^a   Murakami, Manabu ^a  

^a EISAI CO LTD   (Japan)

Author keywords

5 Lipoxygenase; E3040; Lipopolysaccharide; Thromboxane synthase

Indexed keywords

6 HYDROXY 5,7 DIMETHYL 2 METHYLAMINO 4 (3 PYRIDYLMETHYL)BENZOTHIAZOLE; ANTIINFLAMMATORY AGENT; ARACHIDONATE 5 LIPOXYGENASE; ICOSANOID; LEUKOTRIENE B4; LEUKOTRIENE C4; LEUKOTRIENE D4; LIPOPOLYSACCHARIDE; MYELOPEROXIDASE; PREDNISOLONE; PROSTAGLANDIN E2; SULFADIAZINE; THROMBOXANE B2; THROMBOXANE SYNTHASE;

ARTICLE; BLOOD VESSEL PERMEABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFECT; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME SYNTHESIS; INTESTINE INJURY; LARGE INTESTINE; MALE; NEUTROPHIL; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMALS; BENZOTHIAZOLES; DINOPROSTONE; DOSE-RESPONSE RELATIONSHIP, DRUG; EICOSANOIDS; GASTROINTESTINAL AGENTS; INJECTIONS, INTRAVENOUS; INTESTINAL MUCOSA; INTESTINE, LARGE; LEUKOTRIENE B4; LIPOPOLYSACCHARIDES; LIPOXYGENASE INHIBITORS; MALE; PREDNISOLONE; PYRIDINES; RATS; RATS, INBRED F344; SULFASALAZINE; THIAZOLES; THROMBOXANE B2; THROMBOXANE-A SYNTHASE; TIME FACTORS;

EID: 0035860491     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(01)01234-1     Document Type: Article

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