Is there loss or qualitative changes in the expression of thyroid peroxidase protein in thyroid epithelial cancer?

British Journal of Cancer

Volumn 85, Issue 6, 2001, Pages 875-880

  Czarnocka, B ^a,b   Pastuszko, D ^a   Janota Bzowski, M ^a   Weetman, A P ^c   Watson, P F ^c   Kemp, E H ^c   McIntosh, R S ^d   Asghar, M S ^d   Jarzab, B ^e   Gubala, E ^e   Wloch, J ^e   Lange, D ^e  

^a MEDICAL CENTER FOR POSTGRADUATE EDUCATION   (Poland)

^b MOSSAKOWSKI MEDICAL RESEARCH CENTRE   (Poland)

^c UNIVERSITY OF SHEFFIELD   (United Kingdom)

^d QUEEN S MEDICAL CENTRE   (United Kingdom)

^e INSTITUTE OF ONCOLOGY   (Poland)

Author keywords

Differentiated thyroid cancer; Epitope; Fab; IgG ; mAb; TPO

Indexed keywords

IMMUNOGLOBULIN F(AB) FRAGMENT; IMMUNOGLOBULIN G; MONOCLONAL ANTIBODY; THYROID PEROXIDASE; THYROTROPIN;

ADOLESCENT; ADULT; AGED; ARTICLE; CANCER STAGING; CLINICAL ARTICLE; EPITOPE MAPPING; FEMALE; GRAVES DISEASE; HUMAN; MALE; MICROSOME; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; THYROID CARCINOMA; WESTERN BLOTTING;

ADENOCARCINOMA, FOLLICULAR; ADOLESCENT; ADULT; AGED; ANTIBODIES, MONOCLONAL; BLOTTING, WESTERN; CARCINOMA, PAPILLARY; ELECTROPHORESIS, POLYACRYLAMIDE GEL; EPITOPE MAPPING; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; GRAVES DISEASE; HUMANS; IMMUNOENZYME TECHNIQUES; IODIDE PEROXIDASE; MALE; MICROSOMES; MIDDLE AGED; THYROID DISEASES; THYROID GLAND; THYROID NEOPLASMS;

EID: 0035860146     PISSN: 00070920     EISSN: None     Source Type: Journal    
DOI: 10.1054/bjoc.2001.2015     Document Type: Article

References (21)

1. Purification of the human thyroid peroxidase and its identification as the microsomal antigen involved in autoimmune thyroid diseases
2. Immunoglobulin Gκ antithyroid peroxidase antibodies in Hashimoto's thyroiditis: Epitope-mapping analysis
3. Immunohistochemical study of thyroid peroxidase in normal, hyperplastic, and neoplastic human thyroid tissues
4. Thyroid peroxidase detection as a tool to assist diagnosis of thyroid nodules on fine-needle aspiration biopsy
5. Expression of thyroid-specific transcription factors TTF-1 and Pax-8 in human thyroid neoplasm
6. Evaluation of the monoclonal antibody anti-thyroperoxidase MoAb47 in the diagnostic decision of cold thyroid nodules by fine-needle aspiration
7. Human thyroid peroxidase activity in benign and malignant thyroid disorders
8. Comparison of thyroid peroxidase expression with cellular proliferation in thyroid follicular tumors
9. Gene expression of differentiation and dedifferentiation markers in normal and malignant human thyroid tissues
10. Correlation between thyroid peroxidase activity and histopathological and ultrastructural changes in various thyroid diseases
11. Immunohistochemical demonstration of thyroid peroxidase (TPO) in human thyroid tissues from various thyroid diseases
12. Analysis of immuno-globulin Gκ antithyroid peroxidase antibodies from different tissues in Hashimoto's thyroiditis
13. Studies on the membrane-associated nature of human thyroid peroxidase: A difference in the solubility of the enzyme from benign and malignant thyroid tissues
14. The mRNA levels of thyrotropin receptor, thyroglobulin and thyroid peroxidase in neoplastic human thyroid tissues
15. Relationship between immunological structure and biochemical properties of human thyroid peroxidase
16. Thyroid peroxidase expression and DNA polymorphism in thyroid cancer
17. Immunohistochemical loss of thyroid peroxidase in papillary thyroid carcinoma: Strong suppression of peroxidase gene expression
18. Differential expression of dipeptidyl peptidase IV (CD26) and thyroid peroxidase in neoplastic thyroid tissues
19. Thyroid peroxidase, thyroglobulin, cAMP, and DNA in human thyroid
20. Subcellular distribution of peroxidase activity in human thyroid tissue
21. Immunohistological differentiation of benign thyroid follicular cell tumors from malignant ones: Usefulness of anti-peroxidase and JT-95 antibodies