CDT a valuable marker for over-consumption of alcohol. Principles for use in testing prior to obtaining a drivers license;CDT värdefull markör för överkonsumtion av alkohol: Riktlinjer för dess användning vid körkortsprövning

Lakartidningen

Volumn 98, Issue 7, 2001, Pages 677-683

  Bjerre, Bo ^a,d   Borg, Stefan ^b   Jeppsson, Jan Olof ^c   Johnson, Göran ^c   Karlsson, Gunilla ^b  

^a Vägverket ^*  (Sweden)

^b Beroendecentrum Nord   (Sweden)

^c LUND UNIVERSITY HOSPITAL   (Sweden)

^d SWEDISH TRANSPORT ADMINISTRATION   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MARKER; TRANSFERRIN;

ALCOHOLISM; ARTICLE; BLOOD; CHEMISTRY; DRINKING BEHAVIOR; DRIVER LICENCE; GENETICS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; LABORATORY DIAGNOSIS; LEGAL ASPECT; METABOLISM; PRACTICE GUIDELINE; PSYCHOLOGICAL ASPECT; SWEDEN;

ALCOHOL DRINKING; ALCOHOLISM; AUTOMOBILE DRIVER EXAMINATION; BIOLOGICAL MARKERS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; FALSE POSITIVE REACTIONS; GUIDELINES; HUMANS; PRACTICE GUIDELINES; SWEDEN; TRANSFERRIN;

EID: 0035857523     PISSN: 00237205     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (23)

1. Norström T. Utvärdering av 1990 års reform av trafikbrottslagen, 1996.
2. Alling C. Markörer vid alkoholism. Läkartidningen 1992; 89: 3261-7.
3. Helander A, Jones AW. Biochemical tests for acute and chronic alcohol ingestion. In: Karch S, ed. Drug abuse handbook. Boca Raton, FL: CRC Press, 1998:374-94.
4. Kristenson H, Trell E, Hood B. Serum gamma-glutamyltransferase in screening and continuous control of heavy drinking in middle-aged men. Am J Epidemiol 1981; 114: 862-72.
5. Seppä K, Laippala P, Saarni M. Macrocytosis as a consequence of alcohol abuse among patients in general practice. Alcohol Clin Exp Res 1991; 15: 871-6.
6. Stibler H. Carbohydrate-deficient transferrin in serum. A new marker of potentially harmful alcohol consumption reviewed. Clin Chem 1991; 37: 2029-37.
7. Landberg E, Påhlsson P, Lundblad A, Arnetorp A, Jeppson JO. Carbohydrate composition of serum transferrin isoforms from patients with high alcohol consumption. Biochem Biophys Res Commun 1995; 210: 267-74.
8. Nilsson JE, von Schenck H, Larsson B, Bäck SE, Norlund L, Jeppsson JO. Carbohydrate-deficient transferrin (CDT) determined by HPLC: Reference interval in a random cross-section of the population. (Under publicering)
9. Jeppsson JO, Kristenson H, Fimiani C. Carbohydrate-deficient transferrin quantified by HPLC to determine heavy consumption of alcohol. Clin Chem 1993; 39: 2115-20.
10. Randell E, Diamandis EP, Goldberg DM. Changes in carbohydrate-deficient transferrin and gammaglutamyltransferase after moderate wine consumption in healthy males. J Clin Lab Anal 1998; 12: 92-7.
11. Anton RF, Moak DH. Carbohydrate deficient transferrin and gamma glutamyl transferase markers of heavy alcohol consumption: Gender differences. Alcohol Clin Exp Res 1994; 18: 747-54.
12. Helander A. Absolute or relative measurement of carbohydrate-deficient transferrin in serum? Experiences with three immunological assays. Clin Chem 1999; 45: 131-5.
13. Heggli DE, Aurebekk A, Granum B, Westby C, Lovli T, Sundrehagen E. Should trisialo-transferrins be included when calculating carbohydrate-deficient transferrin for diagnosing elevated alcohol intake? Alcohol Alcohol 1996; 31: 381-4.
14. Gorg A, Weser J, Westermeier R, Postel W, Weidinger S, Patutschnick W et al. Isoelectric focusing with immobilized pH gradients for the analysis of transferrin (Tf) subtypes and variants. Hum Genet 1983; 64: 222-6.
15. Salaspuro M. Carbohydrate-deficient transferrin as compared to other markers of alcoholism: A systematic review. Alcohol 1999; 19: 261-71.
16. Helander A, Voltaire Carlsson A, Borg S. Longitudinal comparison of carbohydrate-deficient transferrin and gamma-glutamyl transferase: complementary markers of excessive alcohol consumption. Alcohol Alcohol 1996; 31: 101-7.
17. Kristenson H, Jeppsson JO. Undersökningar vid en körkortsmottagning. CD-transferrin värdefull markör på alkoholkonsumtion. Läkartidningen 1998; 95: 1425-30.
18. Bean P, Sutphin MS, Liu Y, Anton R, Reynolds TB, Shoenfeld Y et al. Carbohydrate-deficient transferrin and false-positive results for alcohol abuse in primary bilary cirrhosis: differential diag-nosis by detection of mitochondrial autoantibodies. Clin Chem 1995; 41: 858-61.
19. Radosavljevic M, Temsch E, Hammer J, Pfeffel F, Mayer G, Renner F et al. Elevated levels of carbohydrate deficient transferrin are not specific for alcohol abuse in patients with liver disease. J Hepatol 1995; 23: 706-11.
20. Bell H, Tallaksen C, Try K, Hang E. Carbohydrate deficient transferrin and other markers of high alcohol consumption: a study of 502 patients admitted consecutively to a medical department. Alcohol Clin Exp Res 1994; 18: 1103-5.
21. Fagerberg B, Agewall S, Urbanavicius V, Attvall S, Lundberg PA, Lindstedt G. Carbohydrate-deficient transferrin is associated with insulin sensitivity in hypertensive men. J Clin Endocrinol Metab 1994; 79: 712-5.
22. Whitfield JB, Fletcher LM, Murphy LT, Powell LW, Holliday J, Heath AC et al. Smoking obesity and hypertension after the dose response curve and test sensitivity of carbohydrate-deficient transferrin as a marker of alcohol intake. Clin Chem 1998; 44: 2480-9.
23. Hagberg BA, Blennow G, Kristiansson B, Stibler H. Carbohydrate-deficient glycoprotein syndromes: peculiar group of new disorders. Pediatr neurol 1993; 9: 255-64.