Hyperactivity, neuromotor defects, and impaired learning and memory in a mouse model for metachromatic leukodystrophy

Brain Research

Volumn 907, Issue 1-2, 2001, Pages 35-43

  D'Hooge, Rudi ^a   Van Dam, Debby ^a   Franck, Frieda ^a   Gieselmann, Volkmar ^b   De Deyn, Peter P ^a,c  

^a UNIVERSITY OF ANTWERP   (Belgium)

^b UNIVERSITY OF BONN   (Germany)

^c Born Bunge Neurosciences Foundation   (Belgium)

Author keywords

Hyperactivity; Lysosomal disorder; Metachromatic leukodystrophy; Morris water maze; Transgenic mouse model

Indexed keywords

CEREBROSIDE SULFATASE;

AGE; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; COGNITION; CONTROLLED STUDY; DIAGNOSTIC TEST; DRUG DEFICIENCY; HUMAN; HYPERACTIVITY; LEARNING DISORDER; MAZE TEST; METACHROMATIC LEUKODYSTROPHY; MOTONEURON; MOTOR COORDINATION; MOTOR NEURON DISEASE; MOTOR PERFORMANCE; MOUSE; NONHUMAN; OPEN FIELD TEST; PATHOPHYSIOLOGY; PRIORITY JOURNAL; SPATIAL MEMORY; TREATMENT OUTCOME;

AGE FACTORS; ANIMALS; AVOIDANCE LEARNING; CEREBROSIDE-SULFATASE; EXPLORATORY BEHAVIOR; GENOTYPE; HYPERKINESIS; LEARNING DISORDERS; LEUKODYSTROPHY, METACHROMATIC; MAZE LEARNING; MEMORY DISORDERS; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MODELS, ANIMAL; MOTOR SKILLS DISORDERS; NERVE TISSUE PROTEINS; PSYCHOMOTOR PERFORMANCE; RETENTION (PSYCHOLOGY); SPATIAL BEHAVIOR; SWIMMING;

EID: 0035854585     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-8993(01)02374-5     Document Type: Article

References (23)

1. Age-related behavioural deficits in transgenic mice expressing the HIV-1 coat protein gp120
2. Neuromotor alterations and cerebellar deficits in aged arylsulfatase A-deficient transgenic mice
3. A note on a simple apparatus for detecting neurological deficit in rats and mice
4. L1 knockout mice show dilated ventricles, vermis hypoplasia and impaired exploration patterns
5. Metachromatic leukodystrophy: Molecular genetics and an animal model
6. Molecular genetics of metachromatic leukodystrophy
7. Abnormal expression of neurofilament proteins in dysmyelinating axons located in the central nervous system of jimpy mutant mice
8. The incidence and genetics of metachromatic leukodystrophy in Northern Sweden
9. Phenotype of arylsulfatase A-deficient mice: Relationship to human metachromatic leukodystrophy
10. Models of the cerebellum and motor learning
11. Mice with an aspartylglucosaminuria mutation similar to humans replicate the pathophysiology in patients
12. Metachromatic leukodystrophy and multiple sulfatase deficiency: Sulfatide lipidosis
13. Dysmyelination in 'jimpy' mouse
14. A single nucleotide difference in the gene for myelin proteolipid protein defines the jimpy mutation in mouse
15. Cerebellar contribution to spatial processing: Morris water maze and T-maze
16. Molecular basis of different forms of metachromatic leukodystrophy
17. The differential diagnosis of adult onset metachromatic leukodystrophy and early onset familial Alzheimer disease in an Alzheimer clinic population
18. Neuropsychological outcomes of several storage diseases with and without bone marrow transplantation
19. Characteristics of the dementia in late-onset metachromatic leukodystrophy
20. Mutant mice (quaking and jimpy) with deficient myelination in the central nervous system
21. Animal model of lysosomal disease: An overview
22. Lysosomal disorders
23. Neuronal depletion of cerebellum in late infantile metachromatic leukodystrophy