Determination of the pKa of the four Zn2+-coordinating residues of the distal finger motif of the HIV-1 nucleocapsid protein: Consequences on the binding of Zn2+

Journal of Molecular Biology

Volumn 310, Issue 3, 2001, Pages 659-672

  Bombarda, E ^a   Morellet, N ^b   Cherradi, H ^a   Spiess, B ^c   Bouaziz, S ^b   Grell, E ^d   Roques, B P ^b   Mely Y ^a  

^a UNIVERSITÉ DE STRASBOURG   (France)

^b CNRS   (France)

^c Laboratoire de Pharmacochimie   (France)

^d MAX PLANCK INSTITUTE OF BIOPHYSICS   (Germany)

Author keywords

Fluorescence, zinc; NCp7; NMR; pKa

Indexed keywords

NUCLEOCAPSID PROTEIN; PROTEIN NCP7; UNCLASSIFIED DRUG; ZINC ION; APOPROTEIN; CAPSID PROTEIN; CYSTEINE; GAG PROTEIN; HISTIDINE; NCP7 PROTEIN, HUMAN IMMUNODEFICIENCY VIRUS 1; PROTON; VIRUS PROTEIN; ZINC; ZINC FINGER PROTEIN;

ARTICLE; BINDING AFFINITY; FLUORESCENCE SPECTROSCOPY; HUMAN IMMUNODEFICIENCY VIRUS 1; HYDROGEN BOND; METAL BINDING; MOLECULAR DYNAMICS; NONHUMAN; PH; PKA; POTENTIOMETRY; PRIORITY JOURNAL; PROTEIN STRUCTURE; PROTON NUCLEAR MAGNETIC RESONANCE; PROTON TRANSPORT; AMINO ACID SEQUENCE; CHEMISTRY; COMPUTER SIMULATION; FLUORESCENCE; METABOLISM; MOLECULAR GENETICS; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PHYSIOLOGY; SPECTROFLUOROMETRY; THERMODYNAMICS; VIRUS CAPSID;

HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1; MIRIDAE;

AMINO ACID SEQUENCE; APOPROTEINS; CAPSID; CAPSID PROTEINS; COMPUTER SIMULATION; CYSTEINE; FLUORESCENCE; GENE PRODUCTS, GAG; HISTIDINE; HYDROGEN BONDING; HYDROGEN-ION CONCENTRATION; MAGNETIC RESONANCE SPECTROSCOPY; MOLECULAR SEQUENCE DATA; POTENTIOMETRY; PROTONS; SPECTROMETRY, FLUORESCENCE; THERMODYNAMICS; VIRAL PROTEINS; ZINC; ZINC FINGERS;

EID: 0035854280     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1006/jmbi.2001.4770     Document Type: Article

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