A human volunteer challenge model using frozen bacteria of the new epidemic serotype, V. cholerae O139 in Thai volunteers

Vaccine

Volumn 20, Issue 5-6, 2001, Pages 920-925

  Pitisuttithum, Punnee ^a   Cohen, Mitchell B ^b   Phonrat, Benjaluck ^a   Suthisarnsuntorn, Usanee ^a   Bussaratid, Valai ^a   Desakorn, Varunee ^a   Phumratanaprapin, Weerapong ^a   Singhasivanon, Pratap ^a   Looareesuwan, Sornchai ^a   Schiff, Gilbert M ^b   Ivanoff, Bernard ^c   Lang, Dennis ^d  

^a MAHIDOL UNIVERSITY   (Thailand)

^b UNIVERSITY OF CINCINNATI   (United States)

^c WORLD HEALTH ORGANIZATION   (Switzerland)

^d NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

Author keywords

Antitoxin; Diarrhea; Dose escalation; Vibriocidal serology

Indexed keywords

CHOLERA VACCINE; IMMUNOGLOBULIN A ANTIBODY; IMMUNOGLOBULIN G ANTIBODY; TETRACYCLINE;

ADULT; ARTICLE; CHOLERA; CONTROLLED STUDY; DIARRHEA; DISEASE SEVERITY; DOSE CALCULATION; DRUG EFFICACY; ENDEMIC DISEASE; FECES ANALYSIS; FEMALE; HUMAN; HUMAN EXPERIMENT; IMMUNE RESPONSE; INOCULATION; MALE; NORMAL HUMAN; PRIORITY JOURNAL; THAILAND; VIBRIO CHOLERAE;

ADULT; ANTIBODIES, BACTERIAL; CHOLERA; CHOLERA VACCINES; COLONY COUNT, MICROBIAL; DISEASE OUTBREAKS; FECES; FEMALE; FREEZING; HUMANS; MALE; MODELS, BIOLOGICAL; SEROTYPING; THAILAND; VIBRIO CHOLERAE;

EID: 0035852276     PISSN: 0264410X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0264-410X(01)00381-4     Document Type: Article

References (14)

1. Large epidemic of cholera-like disease in Bangladesh caused by Vibrio cholerae O139 Bengal in India synonym Bengal
2. Spread of Vibrio cholerae O139
3. Cholera in 1995
4. V. cholerae O139 Bengal in Bangkok
5. Vibrio cholerae O139: How great is the threat of a pandemic potential?
6. Protective efficacy in humans of killed whole vibro oral cholera vaccine with or without B submit of cholera toxin
7. Live oral vaccines against cholera: An update
8. Validation and characterization of a human volunteer challenge model for cholera using frozen bacteria of the new epidemic serotype, V. cholerae O139
9. Validation of a volunteer model of cholera with frozen bacteria as the challenge
10. Clinical and immunologic characteristics of Vibrio cholerae O139 Bengal infection in North American volunteers
11. Initial clinical studies of CVD 112 Vibrio cholerae O139 live oral vaccine: Safety, efficacy against experimental challenge
12. Clinical and bacteriological studies of El Tor cholera after ingestion of known inocula in Thai volunteers
13. Synergistic protective effect in rabbits of immunization with Vibrio cholerae lipopolysaccharide and toxin/toxoid