Activation of programmed cell death (apoptosis) by adriamycin in human neoplastic cells

Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis

Volumn 484, Issue 1-2, 2001, Pages 87-93

  Gruber, Beata M ^a   Anuszewska, Elzbieta L ^a   Skierski, Janusz S ^a  

^a NATIONAL MEDICINES INSTITUTE   (Poland)

Author keywords

Adriamycin; Apoptosis; Flow cytometry

Indexed keywords

DOXORUBICIN;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CELL STRUCTURE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG SENSITIVITY; FLOW CYTOMETRY; FLUORESCENCE MICROSCOPY; HUMAN; HUMAN CELL; MELANOMA; PRIORITY JOURNAL;

ANTINEOPLASTIC AGENTS; APOPTOSIS; DOXORUBICIN; DRUG RESISTANCE, NEOPLASM; FLOW CYTOMETRY; FLUORESCENT DYES; HUMANS; INDOLES; MELANOMA; MICROSCOPY, FLUORESCENCE; RHODAMINES; TUMOR CELLS, CULTURED;

EID: 0035852081     PISSN: 00275107     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0027-5107(01)00256-1     Document Type: Article

References (9)

1. A critical evaluation of the mechanisms of action proposed for the antitumor effects of the anthracycline antibiotics adriamycin and daunomycin
2. Apoptosis induced by anthracycline antibiotics in P388 parent and multidrug-resistant cells
3. DNA damage and repair in normal and neoplastic cells treated with adriamycin
4. Studies on adaptation to adriamycin in cells pretreated with hydrogen peroxide
5. Growth arrest and non-apoptotic cell death associated with the suppression of c-myc expression in MCF-7 breast tumor cells following acute exposure to doxorubicin
6. p53 status affects the rate of the onset but not the overall extent of doxorubicin-induced cell death in Rat-1 fibroblasts constitutively expressing c-myc
7. Abrogation of adriamycin toxicity in vivo by cycloheximide
8. Adriamycin and daunomycin induce programmed cell death (apoptosis) in tumor cells
9. Doxorubicin-induced DNA degradation in murine thymocytes