Effect of the deletion of US2 and US3 from herpes simplex virus type 2 on immune responses in the murine vagina following intravaginal infection

Vaccine

Volumn 20, Issue 1-2, 2001, Pages 98-104

  Inagaki Ohara, Kyoko ^a   Iwasaki, Takuya ^b   Watanabe, Daisuke ^a   Kurata, Takeshi ^b   Nishiyama, Yukihiro ^a  

^a NAGOYA UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b NATIONAL INSTITUTE OF INFECTIOUS DISEASES   (Japan)

Author keywords

Host immunity; HSV; US2; US3

Indexed keywords

GAMMA INTERFERON; HERPES SIMPLEX VACCINE; INTERLEUKIN 12;

ANIMAL CELL; ANIMAL MODEL; ARTICLE; CLEARANCE; CONTROLLED STUDY; DENDRITIC CELL; FEMALE; FLOW CYTOMETRY; GENE INACTIVATION; GENITAL HERPES; HERPES SIMPLEX; HERPES SIMPLEX VIRUS 2; IMMUNE RESPONSE; INFECTION PREVENTION; MACROPHAGE; MONONUCLEAR CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE; VAGINA; VAGINA MUCOSA; VIROGENESIS; VIRUS INDUCTION; VIRUS STRAIN;

ADMINISTRATION, INTRAVAGINAL; ANIMALS; ANTIGEN PRESENTATION; DENDRITIC CELLS; FEMALE; HERPES GENITALIS; HERPESVIRUS 2, HUMAN; INTERFERON TYPE II; INTERLEUKIN-12; INTERLEUKIN-4; LYMPHOCYTE ACTIVATION; MACROPHAGE ACTIVATION; MACROPHAGES; MICE; MICE, INBRED BALB C; MUCOUS MEMBRANE; PROTEIN-SERINE-THREONINE KINASES; SEQUENCE DELETION; T-LYMPHOCYTE SUBSETS; VAGINA; VIRAL ENVELOPE PROTEINS; VIRAL PROTEINS; VIRUS REPLICATION;

EID: 0035851001     PISSN: 0264410X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0264-410X(01)00311-5     Document Type: Article

References (34)

1. Latent infection of sensory ganglia with herpes simplex virus: Efficacy of immunization
2. Langerhans cells and T lymphocyte subsets in the murine vagina and cervix
3. Characterization of neutrophiles and T lymphocytes associated with the murine vaginal epithelium
4. Analysis of herpes simplex virus-specific T cells in the murine female genital tract following genital infection with herpes simplex virus type 2
5. Mucosal immunity to herpes simplex virus type 2 infection in the mouse vagina is impaired by in vivo depletion of T lymphocytes
6. T lymphocytes are required for protection of the vaginal mucosa and sensory ganglia of immune mice against reinfection with herpes simplex virus type
7. Influence of mucosal and parenteral immunization with a replication-defective mutant of HSV-2 on immune responses and protection from genital infection
8. Induction of a protective immune response by mucosal vaccination with a DISC HSV-1 vaccine
9. Construction of a US3 lacZ insertion: Mutant of herpes simplex virus type 2 and characterization of its phenotype in vitro and in vivo
10. Purification and biological characterization of the protein kinase encoded by the US3 gene of herpes simplex virus type 2
11. Characterization of the herpes simplex virus type 2 (HSV-2) US2 gene product and a US2-deficient HSV-2 mutant
12. Alpha herpes viruses possess a gene homologous to the protein kinase gene family of eukaryotes and retroviruses
13. The herpes simplex virus 1 protein kinase US3 is required for protection from apoptosis induced by the virus
14. US3 protein kinase of herpes simplex virus type 2 plays a role in protecting corneal epithelial cells from apoptosis in infected mice
15. Impaired induction of protective immunity by highly virulent herpes simplex virus type 2 in a murine model of genital herpes
16. A mouse model for studies of mucosal immunity to vaginal infection by herpes simplex virus type 2
17. Interferon-γ enhances resolution of herpes simplex virus type 2 infection of the murine genital tract
18. Gamma delta T cells of the murine vagina: T cell response in vivo in the absence of the expression of CD2 and CD28 molecules
19. Potential for involvement of Fas antigen/Fas ligand interaction in apoptosis of epithelial cells by intraepithelial lymphocytes in murine small intestine
20. Effects of a nonapeptide thymic hormone on intestinal intraepithelial lymphocytes in mice following administration of 5-fluorouracil
21. The pathogenicity of a US3 protein kinase-deficient mutant of herpes simplex virus type 2 in mice
22. The role of polymorphonuclear leukocyte infiltration in herpes simplex virus infection of murine skin
23. Expression of surface antigens during the differentiation of human dendritic cells versus macrophages from blood monocytes in vitro
24. T cell help for cytotoxic T lymphocytes is mediated by CD40-CD40L interactions
25. Role of CD28/CD80-86 and CD40/CD154 co-stimulatory interactions in host defense to primary herpes simplex virus infection
26. + T cells through IL-12 produced by Listeria-induced macrophages
27. Regulation of human cytolytic lymphocyte responses by interleukin-12
28. HLA class I molecules are not transported to the cell surface in cells infected with herpes simplex virus types 1 and 2
29. + T lymphocytes
30. Impairment of antigen-specific T-cell priming in mice lacking CD40 ligand
31. CD40 ligand-transduced co-stimulation of T cells in the development of helper function
32. Cellular responses to interferon-gamma
33. Herpes simplex virus type 2 induces secretion of IL-12 by macrophages through a mechanism involving NF-kappa B
34. Expression of herpes simplex virus type 2 US3 affects the Cdc42/Rac pathway and attenuates c-Jun N-terminal kinase activation