Met-Ile-Phe-Leu derivatives: Full and partial agonists of human neutrophil formylpeptide receptors

European Journal of Pharmacology

Volumn 411, Issue 3, 2001, Pages 327-333

  Dalpiaz, Alessandro ^a   Scatturin, Angelo ^a   Vertuani, Gianni ^a   Pecoraro, Rita ^a   Borea, Pier Andrea ^a   Varani, Katia ^a   Traniello, Serena ^a   Spisani, Susanna ^a  

^a UNIVERSITY OF FERRARA   (Italy)

Author keywords

Formylpeptide receptor; Full agonist, Partial agonist, Neutrophil functionality; Neutrophil, human

Indexed keywords

CHEMOATTRACTANT; FORMYLPEPTIDE; METHIONYLISOLEUCYLPHENYLALANYLLEUCINE; UNCLASSIFIED DRUG;

ANION TRANSPORT; ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL FUNCTION; CHEMOTAXIS; DERIVATIZATION; HUMAN; HUMAN CELL; HYDROGEN BOND; MOLECULAR CLONING; PHAGOCYTOSIS; PRIORITY JOURNAL; RECEPTOR AFFINITY; RECEPTOR BINDING;

CELL MOVEMENT; CHEMOTAXIS, LEUKOCYTE; HUMANS; NEUTROPHILS; OLIGOPEPTIDES; RECEPTORS, FORMYL PEPTIDE; RECEPTORS, IMMUNOLOGIC; RECEPTORS, PEPTIDE; SUPEROXIDES;

EID: 0035847140     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(00)00908-0     Document Type: Article

References (32)

1. The use of esters of N-hydroxy-succinimide in peptide synthesis
2. Peptides with agonist and antagonist chemotactic activity
3. Structure and function of leukocyte chemoattractant receptors
4. Mechanisms of autoimmune disease induction. The role of the immune response to microbial pathogens
5. Mithocondrial N-formylmethionyl proteins as chemoattractans for neutrophils
6. Phe-D-Leu-Phe-D-Leu-Phe derivatives as formylpeptide receptor antagonists in human neutrophils: Cellular and conformational aspects
7. Role of peptide backbone conformation on biological activity of chemotactic peptides
8. Subtle differences between human and rabbit neutrophil receptors shown by the secretagogue activity of constrained formyl peptides
9. Selective inhibition of N-formylpeptide-induced neutrophil activation by carbamate-modified peptide analogues
10. Binding of N-formylated chemotactic peptides in crystals of the Mcg light chain dimer: Similarities with neutrophil receptors
11. Studies on fMLP-receptor interaction and signal transduction pathway by means of FMLP-OMe selective analogues
12. Further studies on the structural requirements for synthetic peptide chemoattractants
13. Peptide chemoattractants: A model of the receptor rabbit neutrophils
14. N-terminus urea-substituted chemotatic peptides: New potent agonists and antagonists toward the neutrophil fMLF receptor
15. Receptor up-regulation, internalization, and interconverting receptor states. Critical components of a quantitative description of N-formyl peptide receptor dynamics in the neutrophil
16. Interconverting receptor states af 4°C for the neutrophil N-formylpeptide receptor
17. Conformationally constrained chemotactic peptide analogs of high biological activity
18. Rapid modulation of N-formyl chemotactic peptide receptors on the surface of human granulocytes: Formation of high affinity ligand-receptor complexes in transient association with cytoskeleton
19. Guanine nucleotides modulate the binding affinity of the oligopeptide chemoattractant receptor on human polymorphonuclear leukocytes
20. Rapid and efficient mehod for the N-formylation of C-blocked peptides
21. Purification and identification of formyl-methionyl-leucyl-phenylalanine as the major peptide neutrophil chemotatctic factor produced by Escherichia coli
22. Spectrum of horse-heart cytochrome c
23. Inhibition of neutrophil derived lysosomal enzymes and reactive oxygen species by a novel tetrapeptide
24. Identification of a ligand binding site in the human neutrophil formyl peptide recetor using a site-specific fluorescent photoaffinity label and mass spectrometry
25. The N-formyl peptide receptor: A model for the study of chemoattractant receptor structure and function
26. A series of six ligands for the human formyl peptide receptor: Tetrapeptides with high chemotactic potency and efficacy
27. Neutrophils, host defense and inflammation: A double-edged sword
28. Modification of the amide bond at position 3 in fMLP analogs select neutrophil functions
29. 6c-Phe-OMe
30. Conformational studies of synthetic tripeptide chemoattractants
31. Leukocyte locomotion and chemotaxis. New methods for evaluation and demonstration of a cell-derived chemotactic factor