Synthesis and antiviral activity of novel 5-(1-cyanamido-2-haloethyl) and 5-(1-hydroxy(or methoxy)-2-azidoethyl) analogues of uracil nucleosides

Journal of Medicinal Chemistry

Volumn 44, Issue 21, 2001, Pages 3531-3538

  Kumar, R ^a   Rai, D ^a   Sharma, S K ^a   Saffran, H A ^a   Blush, R ^a   Lorne, D ^a   Tyrrell, J ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

5 (1 AZIDO 2 BROMOETHYL) 2' DEOXYURIDINE; 5 (1 CYANAMIDO 2 BROMOETHYL) 2' DEOXYURIDINE; 5 (1 CYANAMIDO 2 BROMOETHYL)ARABINOURIDINE; 5 (1 CYANAMIDO 2 CHLOROETHYL) 2' DEOXYURIDINE; 5 (1 CYANAMIDO 2 IODOETHYL) 2' DEOXYURIDINE; 5 (1 CYANAMIDO 2 IODOETHYL)ARABINOURIDINE; 5 (1 HYDROXY 2 AZIDOETHYL) 2' DEOXYURIDINE; 5 (1 METHOXY 2 AZIDOETHYL) 2' DEOXYURIDINE; 5 (2 BROMOVINYL) 2' DEOXYURIDINE; ACICLOVIR; ARABINOURIDINE DERIVATIVE; EDOXUDINE; GANCICLOVIR; LAMIVUDINE; MITOGENIC AGENT; THYMIDINE KINASE; UNCLASSIFIED DRUG; URACIL DERIVATIVE;

ANIMAL CELL; ANTIVIRAL ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; HEPATITIS B VIRUS; HERPES SIMPLEX VIRUS 1; HERPES SIMPLEX VIRUS 2; HUMAN; HUMAN CELL; HUMAN CYTOMEGALOVIRUS; IN VITRO STUDY; NONHUMAN; T LYMPHOCYTE; VARICELLA ZOSTER VIRUS; VIRUS REPLICATION;

ANIMALS; ANTI-HIV AGENTS; ANTINEOPLASTIC AGENTS; ANTIVIRAL AGENTS; AZIDES; CELL LINE; CERCOPITHECUS AETHIOPS; CYTOMEGALOVIRUS; DEOXYURIDINE; DRUG SCREENING ASSAYS, ANTITUMOR; HEPATITIS B VIRUS, DUCK; HERPESVIRUS 3, HUMAN; HUMANS; SIMPLEXVIRUS; STRUCTURE-ACTIVITY RELATIONSHIP; TUMOR CELLS, CULTURED; URACIL NUCLEOTIDES; VIRUS REPLICATION;

EID: 0035846073     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm010226s     Document Type: Article

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