pH-dependent blocking actions of three novel antiarrhythmic compounds on K+ and Na+ currents in rat ventricular myocytes

European Journal of Pharmacology

Volumn 425, Issue 2, 2001, Pages 95-107

  Franciosi, Sonia ^a   McLarnon, James G ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

Antiarrhythmic; Hydrogen ion concentration; Inward Na+ current (INa); Open channel blockade; Patch clamp; Transient outward current (Ito)

Indexed keywords

1 NAPHTHALENEACETIC ACID 2 MORPHOLINOCYCLOHEXYL ESTER; [2 (3 OXOPYRROLIDINYL) 1 (1 NAPHTHALENETHOXY)]CYCLOHEXANE; [2 MORPHOLINYL 1 (1 NAPHTHALENETHOXY)]CYCLOHEXANE; [2 MORPHOLINYL 1 (2 NAPHTHALENETHOXY)]CYCLOHEXANE; ANTIARRHYTHMIC AGENT; NAPHTHYL GROUP; NAPHTHYLETHOXYCYCLOHEXYLAMINE DERIVATIVE; POTASSIUM CHANNEL BLOCKING AGENT; RSD 1067; RSD 1070; RSD 1108; SODIUM CHANNEL BLOCKING AGENT; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL ISOLATION; CONTROLLED STUDY; DRUG INHIBITION; DRUG POTENCY; DRUG STRUCTURE; HEART MUSCLE CELL; MALE; NONHUMAN; PH; POTASSIUM CURRENT; PRIORITY JOURNAL; RAT; SODIUM CURRENT;

ANIMALS; ANTI-ARRHYTHMIA AGENTS; CELLS, CULTURED; ELECTROPHYSIOLOGY; HEART VENTRICLES; HYDROGEN-ION CONCENTRATION; KINETICS; MALE; MORPHOLINES; MYOCARDIUM; NAPHTHALENES; PATCH-CLAMP TECHNIQUES; POTASSIUM CHANNELS; RATS; RATS, SPRAGUE-DAWLEY; SODIUM CHANNELS; TIME FACTORS;

EID: 0035839225     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(01)01178-5     Document Type: Article

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