CB1 receptor mediated analgesia from the Nucleus Reticularis Gigantocellularis pars alpha is activated in an animal model of neuropathic pain

Brain Research

Volumn 908, Issue 1, 2001, Pages 67-74

  Monhemius, R ^a,c   Azami, J ^b   Green, D L ^a   Roberts, M H T ^a  

^a CARDIFF UNIVERSITY   (United Kingdom)

^b UNIVERSITY HOSPITAL OF WALES   (United Kingdom)

^c UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

Cannabinoid CB1; Descending inhibition; Nociception; Pain

Indexed keywords

2,3 DIHYDRO 5 METHYL 3 (MORPHOLINOMETHYL) 6 (1 NAPHTHOYL)PYRROLO[1,2,3 DE][1,4]BENZOXAZINE; CANNABINOID 1 RECEPTOR; FORMALDEHYDE; RIMONABANT;

ANALGESIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINOCICEPTION; ARTICLE; BEHAVIOR; CONTROLLED STUDY; GIGANTOCELLULAR RETICULAR NUCLEUS; MALE; NERVE LIGATION; NONHUMAN; PAIN; PHARMACOLOGICAL BLOCKING; PRIORITY JOURNAL; RAT; SCIATIC NERVE; STIMULATION; TAIL FLICK TEST; WITHDRAWAL REFLEX;

ANALGESIA; ANALGESICS; ANIMALS; DISEASE MODELS, ANIMAL; DRUG INTERACTIONS; MALE; MEDULLA OBLONGATA; MORPHOLINES; NAPHTHALENES; NERVE CRUSH; NEURALGIA; NEURONS; PAIN MEASUREMENT; PERIPHERAL NERVOUS SYSTEM DISEASES; PIPERIDINES; PYRAZOLES; RATS; RATS, WISTAR; REACTION TIME; RECEPTORS, CANNABINOID; RECEPTORS, DRUG; RETICULAR FORMATION;

EID: 0035838275     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-8993(01)02605-1     Document Type: Article

References (28)

1. The contribution of nucleus reticularis paragigantocellularis and nucleus raphe magnus to the analgesia produced by systemically administered morphine, investigated with the microinjection technique
2. The behavioural importance of dynamically activated descending inhibition from the nucleus reticularis gigantocellularis pars alpha
3. Conformationally restrained analogues of pravadoline: Nanomolar potent, enantioselective, (aminoalky-1)indole agonists of the cannabinoid receptor
4. A method for determining loss of pain sensation
5. Determination and characterisation of a cannabinoid receptor in rat brain
6. Isolation and structure of a brain constituent that binds to the cannabinoid receptor
7. The formalin test: A quantative study of the analgesic effects of morphine, meperidine, and brain stem stimulation in rats and cats
8. Characterisation and localisation of cannabinoid receptors in rat brain: A quantitative in vitro autoradiographic study
9. The analgesic effects of R(+)WIN 55,212-2 mesylate, a high affinity cannabinoid agonist, in a rat model of neuropathic pain
10. Cannabinoid suppression of noxious heat-evoked activity in wide dynamic range neurons in the lumbar dorsal horn of the rat
11. Supraspinal inhibition of nociceptive dorsal horn neurones in the anaesthetised rat: Tonic or dynamic?
12. The cannabinoid receptor agonist WIN 55,212-1 mesylate blocks the development of hyperalgesia produced by capsaicin in rats
13. Analgesia from electrical stimulation of the periaqueductal gray matter in the cat: Behavioural observations and inhibitory effects on spinal cord interneurons
14. Two distinct antinociceptive systems in rats with pathological pain
15. Suppression of noxious stimulus-evoked activity in the ventral posterolateral nucleus of the thalamus by a cannabinoid agonist: Correlation between electrophysiological and antinociceptive effects
16. Cannabinoid receptor-mediated inhibition of the rat tail-flick reflex after microinjection into the rostroventral medulla
17. Anatomical basis for cannabinoid induced antinociception as revealed by intracerebral microinjections
18. Spinal cannabinoids are anti-allodynic in rats with persistent inflammation
19. Identification of an endogenous 2-monoglyceride, present in canine gut, that binds to cannabinoid receptors
20. Surgery in the rat during electrical analgesia induced by focal brain stimulation
21. Antihyperalgesic effects of spinal cannabinoids
22. SR141716A, a potent and selective antagonist of the brain cannabinoid receptor
23. A novel behavioural model of neuropathic pain disorders produced in rats by partial sciatic nerve injury
24. Evidence for a role of endogenous cannabinoids in the modulation of acute and tonic pain sensitivity
25. The neurobiology of cannabinoid analgesia
26. Pain modulation by release of the endogenous cannabinoid anandamide
27. The pathophysiology of chronic pain-increased sensitivity to low threshold Ab-fibre inputs