Synthesis, photophysical properties, tumor uptake, and preliminary in vivo photosensitizing efficacy of a homologous series of 3-(1′-alkyloxy)-ethyl-3-devinylpurpurin-18-N-alkylimides with variable lipophilicity

Journal of Medicinal Chemistry

Volumn 44, Issue 10, 2001, Pages 1540-1559

  Zheng, G ^a   Potter, W R ^a   Camacho, S H ^a   Missert, J R ^a   Wang, G ^b   Bellnier, D A ^a   Henderson, B W ^a   Rodgers, M A J ^b   Dougherty, T J ^a   Pandey, R K ^a  

^a ROSWELL PARK CANCER INSTITUTE   (United States)

^b BOWLING GREEN STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

12 (HYDROXYMETHYL)PURPURINIMIDE DERIVATIVE; 12 FORMYLPURPURINIMIDE DERIVATIVE; DICHLOROMETHANE; OXYGEN; PURPURIN DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG ABSORPTION; DRUG ACTIVITY; DRUG EFFICACY; DRUG SCREENING; DRUG SOLUBILITY; DRUG STRUCTURE; DRUG SYNTHESIS; DRUG UPTAKE; IN VIVO STUDY; LIPOPHILICITY; MOUSE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; REACTION ANALYSIS; STRUCTURE ACTIVITY RELATION;

ANIMALS; CHLOROPHYLL; LIGHT; MAGNETIC RESONANCE SPECTROSCOPY; MICE; NEOPLASMS, EXPERIMENTAL; OXYGEN; PHOTOSENSITIZING AGENTS; PORPHYRINS; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; SCATTERING, RADIATION; SINGLET OXYGEN; SPECTROPHOTOMETRY; TRANSPLANTATION, HETEROLOGOUS;

EID: 0035837069     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm0005510     Document Type: Article

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