Differential changes in rat cholinergic parameters subsequent to immunotoxic lesion of the basal forebrain nuclei

Brain Research

Volumn 918, Issue 1-2, 2001, Pages 113-120

  Waite, Jerene J ^a,b   Chen, Andrew D ^b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b VA SAN DIEGO HEALTHCARE SYSTEM   (United States)

Author keywords

Acetycholine microdialysis; Acetylcholine synthesis; Choline acetyltransferase activity; Cholinergic basal forebrain; Immunotoxic lesion; Rat

Indexed keywords

ACETYLCHOLINE; CHOLINE; CHOLINE ACETYLTRANSFERASE; IMMUNOGLOBULIN G; IMMUNOTOXIN; SAPORIN;

ACETYLCHOLINE BRAIN LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BEHAVIOR DISORDER; BRAIN NUCLEUS; CHOLINERGIC NERVE; CONTROLLED STUDY; ENZYME ACTIVITY; FOREBRAIN; FRONTAL CORTEX; HIPPOCAMPUS; IMMUNOTOXICITY; INTERMETHOD COMPARISON; MALE; MICRODIALYSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN SYNTHESIS; RAT; SYNTHESIS;

ACETYLCHOLINE; ANIMALS; ANTIBODIES, MONOCLONAL; BASAL NUCLEUS OF MEYNERT; CHOLINE O-ACETYLTRANSFERASE; CHOLINERGIC AGENTS; CHOLINERGIC FIBERS; DOSE-RESPONSE RELATIONSHIP, DRUG; EXTRACELLULAR SPACE; FRONTAL LOBE; HIPPOCAMPUS; IMMUNOTOXINS; MALE; MICRODIALYSIS; N-GLYCOSYL HYDROLASES; NEURAL PATHWAYS; RATS; RATS, INBRED F344; SEPTAL NUCLEI; TIME FACTORS;

EID: 0035834320     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-8993(01)02968-7     Document Type: Article

References (59)

1. Mechanical deafferentation of basal forebrain-cortical pathways and neurotoxic lesions of the nucleus basalis magnocellularis: Comparative effect on spatial learning and cortical acetylcholine release in vivo
2. Selective immunotoxic lesions of basal forebrain cholinergic cells: Effects on learning and memory in rats
3. Differential effects on spatial navigation of immunotoxin-induced cholinergic lesions of the medial septal area and nucleus basalis magnocellularis
4. Cholinergic projections from the basal forebrain to frontal, parietal, temporal, occipital, and cingulate cortices: A combined fluorescent tracer and acetylcholinesterase analysis
5. Acetylcholine metabolism of a sympathetic ganglion
6. High affinity choline transporter status in Alzheimer's disease tissue from rapid autopsy
7. Specificity of 192 IgG-saporin for NGF receptor-positive cholinergic basal forebrain neurons in the rat
8. Anti-Thy-1 immunotoxin, OX7-saporin, destroys cerebellar Purkinje cells after intraventricular injection in rats
9. NGF increases cortical acetylcholine release in rats with lesions of the nucleus basalis
10. The role of cholinergic projections from the nucleus basalis in memory
11. Behavioural, biochemical and histochemical effects of different neurotoxic amino acids injected into nucleus basalis magnocellularis of rats
12. Age-dependent effect of AF64A on cholinergic activity in the septo-hippocampal pathway of the rat brain: Decreased responsiveness in aged rats
13. Cholinergic mechanisms in learning, memory and dementia: A review of recent evidence
14. Radiochemical microassays for the determination of choline acetyltransferase and acetylcholinesterase activities
15. Complete and selective cholinergic denervation of rat neocortex and hippocampus but not amygdala by an immunotoxin against the p75 NGF receptor
16. Sprouting of cholinergic axons does not occur in the cerebral cortex after nucleus basalis lesions
17. Cortical cholinergic deafferentation following the intracortical infusion of 192 IgG-saporin: A quantitative histochemical study
18. Acetylcholine turnover estimation in brain by gas chromatography/mass spectrometry
19. High affinity choline transport and acetylCoA production in brain and their roles in the regulation of acetylcholine synthesis
20. Medial septal and nucleus basalis magnocellularis lesions produce order memory deficits in rats which mimic symptomatology of Alzheimer's disease
21. Post-mortem changes in high affinity choline uptake
22. Differential alterations of cortical cholinergic and neurotensin markers following ibotenic acid lesions of the nucleus basalis magnocellularis
23. Compensatory elevation of acetylcholine synthesis in vivo by cholinergic neurons surviving partial lesions of the septohippocampal pathway
24. Compensatory changes of in vivo acetylcholine and noradrenaline release in the hippocampus after partial deafferentation, as monitored by microdialysis
25. Hippocampal theta activity following selective lesion of the septal cholinergic system
26. Protein measurement with the Folin phenol reagent
27. Topographic analysis of the innervation of the rat neocortex and hippocampus by the basal forebrain cholinergic system
28. Central cholinergic pathways in the rat: An overview based on an alternative nomenclature
29. AMPA-induced excitotoxic lesions of the basal forebrain: A significant role for the cortical cholinergic system in attentional function
30. Effects of prenatal nicotine exposure on development of central and peripheral cholinergic neurotransmitter systems. Evidence for cholinergic trophic influences in developing brain
31. Spatial learning impairments in rats with selective immunolesion of the forebrain cholinergic system
32. Changes in choline acetyltransferase immunoreactivity and the number of immunoreactive fibers remaining after lesions to the magnocellular basal nucleus of rats
33. Dementia: Animal models of the cognitive impairments produced by degeneration of the basal forebrain cholinergic system
34. Comparative effects of ibotenic acid- and quisqualic acid-induced lesions of the substantia innominata on attentional function in the rat: Further implications for the role of the cholinergic neurons of the nucleus basalis in cognitive processes
35. Effects of intraventricular transplantation of NGF-secreting cells on cholinergic basal forebrain neurons after partial immunolesion
36. Basal forebrain afferent projections modulating cortical acetylcholine, attention, and implications for neuropsychiatric disorders
37. Impulse-flow regulation of high affinity choline uptake in brain cholinergic nerve terminals
38. Overexpression of the high affinity choline transporter in cortical regions affected by Alzheimer's disease. Evidence from rapid autopsy studies
39. Regulatory changes in presynaptic cholinergic function assessed in rapid autopsy material from patients with Alzheimer disease: Implications for etiology and therapy
40. Ribosome-inactivating proteins from the seeds of Saponaria officinalis L. (soapwort), of Agrostemma githago L. (corn cockle) and of Asparagus officinalis L. (asparagus), and from the latex of Hura crepitans L. (sandbox tree)
41. Behavioural, histochemical, and biochemical consequences of selective immunolesions in discrete regions of the basal forebrain cholinergic system
42. Short-term control of the synthesis of acetylcholine
43. Regional differences in ethylcholine mustard aziridinium ion (AF64A)-induced deficits in presynaptic cholinergic markers for the rat central nervous system
44. Behavioral and biochemical consequences of combined lesions of the medial septum/diagonal band and nucleus basalis in the rat when ibotenic acid, quisqualic acid, and AMPA are used
45. 192 Immunoglobulin G-saporin produces graded behavioral and biochemical changes accompanying the loss of cholinergic neurons of the basal forebrain and cerebellar Purkinje cells
46. Time course of cholinergic and monoaminergic changes in rat brain after immunolesioning with 192 IgG-saporin
47. Behavioral and neurobiological alterations induced by the immunotoxin 192-IgG-saporin: Cholinergic and non-cholinergic effects following i.c.v. injection
48. Effects of bilateral ibotenate-induced lesions of the nucleus basalis magnocellularis upon selective cholinergic biochemical markers in the rat anterior cerebral cortex
49. Recovery of neocortical choline acetyltransferase activity following ibotenic acid injection into the nucleus basalis of Meynert in rats
50. Behavioral, biochemical, histological, and electrophysiological effects of 192 IgG-saporin injections into the basal forebrain of rats
51. Immunolesioning: Selective destruction of neurons using immunotoxin to rat NGF receptor
52. Exogenous nerve growth factor increases the activity of high-affinity choline uptake and choline acetyltransferase in brain of Fisher 344 male rats
53. Exogenous NGF affects cholinergic transmitter function and Y-maze behavior in aged Fischer 344 male rats
54. Nerve growth factor (NGF) augments cortical and hippocampal cholinergic functioning after p75NGF receptor-mediated deafferentation but impairs inhibitory avoidance and induces fear-related behaviors
55. Cholinergic systems in mammalian brain and spinal cord
56. High affinity transport of choline into synaptosomes of rat brain
57. Altered NGF protein levels in different brain areas after immunolesion
58. 3H]hemicholinium-3 binding
59. Differential development of cholinergic nerve terminal markers in rat brain regions: Implications for nerve terminal density, impulse activity and specific gene expression