Factors influencing drug release from stearic acid based compacts

International Journal of Pharmaceutics

Volumn 228, Issue 1-2, 2001, Pages 189-198

  Killen, Bronagh U ^a   Corrigan, Owen I ^a  

^a TRINITY COLLEGE DUBLIN   (Ireland)

Author keywords

Benzoic acid; Fatty acid carriers; Release mechanism; Stearic acid

Indexed keywords

BENZOIC ACID; DRUG CARRIER; STEARIC ACID;

ARTICLE; COMPRESSION; CONTROLLED DRUG RELEASE; DISSOLUTION; DRUG DELIVERY SYSTEM; DRUG DOSAGE FORM; DRUG SCREENING; DRUG SOLUBILITY; KINETICS; PARTICLE SIZE; PRIORITY JOURNAL; TIME; VELOCITY;

ALGORITHMS; BENZOATES; DRUG COMPOUNDING; DRUG DELIVERY SYSTEMS; EXCIPIENTS; PARTICLE SIZE; POROSITY; SOLUBILITY; STEARATES; SURFACE PROPERTIES;

EID: 0035834180     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-5173(01)00841-9     Document Type: Article

References (20)

1. Matrix type controlled release systems: I. Effect of percolation on drug dissolution kinetics
2. Diffusion in porous materials above the percolation threshold
3. The influence of excipient particle size, solubility and acid strength on the dissolution of an acidic drug from two-component compacts
4. The effect of dissolution on the surface texture of model solid dosage forms as assessed by non-contact laser profilometry
5. Mechanism of sustained-action medication, theoretical analysis of rate release of solid drugs dispersed in solid matrices
6. The release of macromolecules from fatty acid matrices: Complete factorial study of factors affecting release
7. Particle size effects on fractal dimensions of matrix type slow release systems
8. The role of the drug/excipient particle size ratio in the percolation model for tablets
9. Evaluation of batch-to-batch and manufacturer-to-manufacturer variability in the physical properties of talc and stearic acid
10. Dissolution characteristics of benzoic acid and salicylic acid mixtures in reactive media
11. An investigation into the release of cefuroxime axetil from taste-masked stearic acid microspheres, part 1, the influence of the dissolution medium on the drug release profile and the physical integrity of the microspheres
12. An investigation into the release of cefuroxime axetil from taste-masked stearic acid microspheres II., the effects of buffer composition on drug release
13. An investigation into the release of cefuroxime axetil from taste-masked stearic acid microspheres III, the use of DSC and HSDSC as means of characterising the interaction of the microspheres with buffered media
14. Mechanistic studies of macromolicular drug release from macroporous polymers. 11. Models for the slow kinetics of drug release
15. Mechanistic studies of macromolecular drug release from macroporous polymers I, experiments and preliminary theory concerning completeness of drug release
16. The reliability of a compressed mixture of insulin and palmitic acid to sustain a reduction in hyperglycaemia in rodents