Effect of melting point of chiral terpenes on human stratum corneum uptake

International Journal of Pharmaceutics

Volumn 228, Issue 1-2, 2001, Pages 89-97

  Mackay, Kirsty M B ^a   Williams, Adrian C ^a   Barry, Brian W ^a  

^a UNIVERSITY OF BRADFORD   (United Kingdom)

Author keywords

Chiral enantiomers; Melting point; Penetration enhancers; Stratum corneum uptake; Terpenes

Indexed keywords

DRUG VEHICLE; MENTHOL; NEOMENTHOL; PROPYLENE GLYCOL; TERPENE DERIVATIVE; UNCLASSIFIED DRUG; WATER;

ADULT; AGED; CHIRALITY; CONFERENCE PAPER; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG DELIVERY SYSTEM; DRUG FORMULATION; DRUG PENETRATION; DRUG PURITY; DRUG SOLUBILITY; DRUG UPTAKE; ENANTIOMER; FEMALE; HUMAN; HUMAN TISSUE; LIQUID; MALE; MELTING POINT; PRIORITY JOURNAL; RACEMIC MIXTURE; STRATUM CORNEUM; TEMPERATURE;

CALORIMETRY, DIFFERENTIAL SCANNING; CHEMISTRY, PHYSICAL; CHROMATOGRAPHY, GAS; HUMANS; POLYETHYLENE GLYCOLS; SKIN ABSORPTION; SOLUBILITY; STEREOISOMERISM; TERPENES; VEHICLES;

EID: 0035834175     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-5173(01)00808-0     Document Type: Article

References (34)

1. Human skin penetration enhancement: The synergy of propylene glycol with terpenes
2. The L.P.P. theory of penetration enhancement
3. A rapid method of total lipid extraction and purification
4. Development of transdermal drug delivery systems
5. Sesquiterpene components of volatile oils as skin penetration enhancers for the hydrophilic permeant 5-fluorouracil
6. Modes of action of terpene penetration enhancers in human skin; differential scanning calorimetry, small-angle X-ray diffraction and enhancer uptake studies
7. Oleic acid: Its effects on stratum corneum in relation to (trans)dermal drug delivery
8. Action of penetration enhancers on human skin as assessed by the permeation of model drugs 5-fluorouracil and estradiol. I. Infinite dose technique
9. Advances in drug delivery: Transdermal drug delivery: The ground rules are emerging
10. Effect of freezing on human skin permeability
11. Does solute stereochemistry influence percutaneous penetration?
12. In vitro skin penetration of propranolol enantiomers
13. Testosterone skin permeation enhancement by menthol through formation of a eutectic with drug and interaction with skin lipids
14. Preparation of isolated sheets of stratum corneum
15. Racemate and enantiomers of ketoprofen: Phase diagram, thermodynamic studies, skin permeability and use of chiral permeation enhancers
16. Effect of chiral enhancers on the permeability of optically active and racemic metoprolol across hairless mouse skin
17. Transdermal permeation of chiral compounds
18. Oestradiol permeation through human skin and silastic membrane: Effects of propylene glycol and supersaturation
19. Enantiomeric difference in percutaneous penetration of proponal through exised rat skin
20. Effect of pre-treatment of skin with cyclic monoterpenes on permeation of diclofenac in hairless rat
21. Permeability of the skin
22. Relating the concentration-dependent action of azone and dodecyl-L-pyroglutamate on the structure of excised human stratum corneum to changes in drug diffusivity, partition coefficient and flux
23. Transdermal delivery from eutectic systems: Enhanced permeation of a model drug, ibuprofen
24. Chiral β-blockers for transdermal delivery
25. The enhancement index concept applied to terpene penetration enhancers for human skin and model lipophilic (oestradiol) and hydrophilic (5-fluorouracil) drugs
26. Effects of terpenes and oleic acid as skin penetration enhancers as assessed with time; permeation, partitioning and differential scanning calorimetry
27. Terpene penetration enhancers in propylene glycol/water co-solvent systems: Effectiveness and mechanism of action
28. Effect of menthol on permeability of an optically active and racemic propranolol across guinea pig skin