A novel homozygous deletion at chromosomal band 6q27 in an ovarian cancer cell line delineates the position of a putative tumor suppressor gene

Cancer Letters

Volumn 173, Issue 1, 2001, Pages 63-70

  Lin, Hsingchi ^a   Morin, Patrice J ^a  

^a NATIONAL INSTITUTE ON AGING   (United States)

Author keywords

6q27; Homozygous deletion; Ovarian cancer

Indexed keywords

MICROSATELLITE DNA;

ANALYTIC METHOD; ARTICLE; CANCER CELL CULTURE; CELL LINE; CHROMOSOME DELETION; CLONING; CONTROLLED STUDY; DATA ANALYSIS; DNA FLANKING REGION; EXPRESSED SEQUENCE TAG; FEMALE; GENE DELETION; GENE EXPRESSION; GENE LOCATION; HOMOZYGOSITY; HUMAN; HUMAN CELL; OVARY CANCER; PRIORITY JOURNAL; TUMOR SUPPRESSOR GENE;

CHROMOSOME MAPPING; CHROMOSOMES, HUMAN, PAIR 6; EXPRESSED SEQUENCE TAGS; FEMALE; GENE DELETION; GENES, TUMOR SUPPRESSOR; HOMOZYGOTE; HUMANS; OPEN READING FRAMES; OVARIAN NEOPLASMS; RIBONUCLEASES; RIBOSOMAL PROTEIN S6 KINASES; TUMOR CELLS, CULTURED; TUMOR SUPPRESSOR PROTEINS;

EID: 0035829117     PISSN: 03043835     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3835(01)00677-2     Document Type: Article

References (38)

1. Allelotype of human ovarian cancer
2. Comparison of loss of heterozygosity patterns in invasive low-grade and high-grade epithelial ovarian carcinomas
3. Frequent loss of heterozygosity and three critical regions on the short arm of chromosome 8 in ovarian adenocarcinomas
4. Frequent loss of heterozygosity on chromosomes 6q, 11, and 17 in human ovarian carcinomas
5. Molecular genetic characterization of BRCA1- and BRCA2-linked hereditary ovarian cancers
6. Survival in familial, BRCA1-associated, and BRCA2-associated epithelial ovarian cancer
7. Distinct somatic genetic changes associated with tumor progression in carriers of BRCA1 and BRCA2 germ-line mutations
8. Specific cytogenetic changes in ovarian cancer involving chromosomes 6 and 14
9. Loss of heterozygosity on chromosomal segments 3p, 6q and 11p in human ovarian carcinomas
10. Human epithelial ovarian cancer allelotype
11. Identification of a recurring translocation site involving chromosome 6 in human malignant melanoma
12. Allelotype of human breast carcinoma: A second major site for loss of heterozygosity is on chromosome 6q
13. Allelotype of colorectal carcinomas
14. Loss of heterozygosity for loci on the long arm of chromosome 6 in human malignant melanoma
15. Early involvement of 6q in surface epithelial ovarian tumors
16. Physical map of the D6S149-D6S193 region on chromosome 6Q27 and its involvement in benign surface epithelial ovarian tumours
17. Loss of heterozygosity on the long arm of chromosome 6 in breast cancer: Possibly four regions of deletion
18. A novel region of deletion on chromosome 6q23.3 spanning less than 500 Kb in high grade invasive epithelial ovarian cancer
19. A novel 4 cM minimal deletion unit on chromosome 6q25.1-q25.2 associated with high grade invasive epithelial ovarian carcinomas
20. Suppression of tumorigenicity in human ovarian cancer cell lines is controlled by a 2 cM fragment in chromosomal region 6q24-q25
21. Allele loss on chromosome arm 6q and fine mapping of the region at 6q27 in epithelial ovarian cancer
22. Fluorescence in situ hybridization analysis using cosmid probes to define chromosome 6q abnormalities in ovarian carcinoma cell lines
23. Fine-scale deletion mapping of the distal long arm of chromosome 6 in 70 human ovarian cancers
24. Definition of a commonly deleted region in ovarian cancers to a 300-kb segment of chromosome 6q27
25. Induction of senescence and control of tumorigenicity in BK virus transformed mouse cells by human chromosome 6
26. Loss of heterozygosity on chromosome 6q27 and p53 mutations in epithelial ovarian cancer
27. Evidence for the colonic origin of ovarian cancer cell line SW626
28. Reactivity of a monoclonal antibody with human ovarian carcinoma
29. Comparative properties of five human ovarian adenocarcinoma cell lines
30. Rare activation of the TCF/beta-catenin pathway in ovarian cancer
31. Biological characterization of human epithelial ovarian carcinoma cells in primary culture: The insulin-like growth factor system
32. Analysis of a 69-kb contiguous genomic sequence at a putative tumor suppressor gene locus on human chromosome 6q27
33. Molecular diagnosis of familial adenomatous polyposis
34. Frequent silencing of the GPC3 gene in ovarian cancer cell lines
35. A comparison of expressed sequence tags (ESTs) to human genomic sequences
36. Complete DNA sequence and characterization of a 330-kb VNTR-rich region on chromosome 6q27 that is commonly deleted in ovarian cancer
37. Allelic loss on chromosome 6Q in primary prostate cancer
38. Simple tandem repeat allelic deletions confirm the preferential loss of distal chromosome 6q in melanoma