DRD4 exon 3 variants associated with delusional symptomatology in major psychoses: A study on 2,011 affected subjects

American Journal of Medical Genetics - Neuropsychiatric Genetics

Volumn 105, Issue 3, 2001, Pages 283-290

  Serretti, Alessandro ^a   Lilli, Roberta ^a   Lorenzi, Cristina ^a   Lattuada, Enrico ^a   Smeraldi, Enrico ^a  

^a VITA SALUTE SAN RAFFAELE UNIVERSITY   (Italy)

Author keywords

Dopamine receptors; Genetics; Manic depressive disorder; Phenotype; Schizophrenia

Indexed keywords

DNA; DOPAMINE 4 RECEPTOR;

ADULT; ALLELE; ARTICLE; CONTROLLED STUDY; DELUSION; DNA SEQUENCE; DOPAMINERGIC SYSTEM; EXON; FEMALE; GENOTYPE; HUMAN; MAJOR CLINICAL STUDY; MALE; MANIC DEPRESSIVE PSYCHOSIS; MENTAL DISEASE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PSYCHIATRIC DIAGNOSIS; SYMPTOMATOLOGY;

ADULT; ANALYSIS OF VARIANCE; CASE-CONTROL STUDIES; EXONS; FEMALE; GENE FREQUENCY; GENETIC SCREENING; GENOTYPE; HUMANS; MALE; MIDDLE AGED; PSYCHOTIC DISORDERS; RECEPTORS, DOPAMINE D2; RECEPTORS, DOPAMINE D4; SCHIZOPHRENIA, PARANOID; VARIATION (GENETICS);

EID: 0035826476     PISSN: 15524841     EISSN: 1552485X     Source Type: Journal    
DOI: 10.1002/ajmg.1321     Document Type: Article

References (109)

1. DRD4 dopamine receptor genotype and CSF monoamine metabolites in Finnish alcoholics and controls
2. The family history method using diagnostic criteria: Reliability and validity
3. Symptoms of schizophrenia: Methods, meanings, and mechanisms
4. Modulation of intracellular cyclic AMP levels by different human dopamine D4 receptor variants
5. Response to clozapine in acute mania is more rapid than that of chlorpromazine
6. Alleles at the dopamine D4 receptor locus do not contribute to the genetic susceptibility to schizophrenia in a large Swedish kindred
7. Population and familial association between the D4 dopamine receptor and measures of novelty seeking
8. Family-based association study between bipolar disorder and DRD2, DRD4, DAT, and SERT in Sardinia
9. Clinical similarities in siblings with schizophrenia
10. Clozapine for treatment-refractory mania
11. Genetic study of dopamine D1, D2, and D4 receptors in schizophrenia
12. Factor analysis of schizophrenic symptoms using the OFCRIT checklist
13. Factor-derived subsyndromes of schizophrenia and familial morbid risks
14. Sibling pairs with schizophrenia or schizoaffective disorder: Associations of subtypes, symptoms and demographic variables
15. Lack of an association between a dopamine-4 receptor polymorphism and attention-deficit/hyperactivity disorder: Genetic and brain morphometric analyses
16. Distribution of novel mutation in the first exon of the human dopamine D4 receptor gene in psychotic patients
17. Grey matter correlates of syndromes in schizophrenia: A semi-automated analysis of structural magnetic resonance images
18. Association study of the repeat polymorphism in exon 3 of the dopamine receptor gene in schizophrenia
19. Identification of two novel polymorphisms and a rare deletion variant in the human dopamine D4 receptor gene
20. Turning point in the design of linkage studies of schizophrenia
21. Mapping genes for human personality
22. The time course of nonchronic major depressive disorder: Uniformity across episodes and samples - National Institute of Mental Health Collaborative Program on the Psychobiology of Depression
23. Psychopathological dimensions in schizophrenia
24. Repeat length variation in the dopamine D4 receptor gene shows no evidence of association with schizophrenia
25. Association study of a null mutation in the dopamine D4 receptor gene in Italian patients with obsessive-compulsive disorder, bipolar mood disorder and schizophrenia
26. Association study between dopamine D1, D2, D3, and D4 receptor genes and schizophrenia defined by several diagnostic systems
27. Dopamine D4 receptor (D4DR) exon III polymorphism associated with the human personality trait of novelty seeking
28. Saga of an adventure gene: Novelty seeking, substance abuse and the dopamine D4 receptor (D4DR) exon III repeat polymorphism
29. A haplotype relative risk study of the dopamine D4 receptor (DRD4) exon III repeat polymorphism and attention deficit hyperactivity disorder (ADHD)
30. Association between novelty seeking and the type 4 dopamine receptor gene in a large Finnish cohort sample
31. Dopamine D-4 gene 7-repeat allele and attention deficit hyperactivity disorder
32. Association of unipolar major depressive disorder with genes of the serotonergic and dopaminergic pathways
33. Association between obsessive-compulsive disorder and polymorphisms of genes encoding components of the serotonergic and dopaminergic pathways
34. Linkage of DFNB1 to non-syndromic neurosensory autosomal-recessive deafness in Mediterranean families
35. Molecular genetics of psychopathologies: A search for simple answers to complex problems
36. No association of the dopamine DRD4 receptor (DRD4) gene polymorphism with attention deficit hyperactivity disorder (ADHD) in the Irish population
37. Dopamine D4 receptor variants in Chinese sporadic and familial schizophrenics
38. Twelve-nucleotide repeat polymorphism of D4 dopamine receptor gene in Chinese familial schizophrenic patients
39. A search for association between schizophrenia and dopaminerelated alleles
40. Lack of evidence for allelic association between personality traits and the dopamine D4 receptor gene polymorphisms
41. Lack of association between dopamine D4 receptor gene and personality traits
42. New developments in dopamine and schizofrenia
43. Dopamine D4 receptor 48-bp repeat polymorphism: No association with response to antipsychotic treatment, but association with catatonic schizophrenia
44. Resemblance of psychotic symptoms and syndromes in affected sibling pairs from the Irish study of high-density schizophrenia families: Evidence for possible etiologic heterogeneity
45. Dopamine D4 receptor gene polymorphisms: Relation to ethnicity, no association with schizophrenia and response to clozapine in Israeli subjects
46. Failure to replicate an excess of the long dopamine D4 exon III repeat polymorphism in ADHD in a family-based study
47. A rapid non-enzimatic method for the preparation of HMW DNA from blood for RFLP studies
48. Dopamine D4 receptor gene polymorphism is associated with attention deficit hyperactivity disorder
49. Best estimate of lifetime psychiatric diagnosis: A methodological study
50. Association analysis between dopamine receptor genes and bipolar affective disorder
51. A hipervariable segment in the dopamine receptor D4 (DRD4) gene
52. The symptoms of chronic schizophrenia: A re-examination of the positive-negative dichotomy
53. Linkage between tyrosine hydroxylase gene and affective disorder cannot be excluded in two of six pedigrees
54. No evidence of association between dopamine D4 receptor variants and bipolar affective disorder
55. Familial associations of subsyndromes of psychosis in affected sibling pairs with schizophrenia and schizoaffective disorder
56. Analysis of the D4 dopamine receptor gene variant in an Italian schizophrenia kindred
57. An association study between schizophrenia and the dopamine receptor genes DRD3 and DRD4 using haplotype relative risk
58. Absence of linkage between schizophrenia and the dopamine D4 receptor gene
59. Dopamine D2, D3 and D4 receptor and transporter gene polymorphisms and mood disorders
60. Full-length cDNA cloning and distribution of human dopamine D4 receptor
61. Negative, psychoticism, and disorganized dimensions in patients with familial schizophrenia or bipolar disorder: Continuity and discontinuity between the major psychoses
62. Long-term stability of diagnosis and symptom dimensions in a systematic sample of patients with onset of schizophrenia in childhood and early adolescence. II. Postnegative distinction and childhood predictors of adult outcome
63. A polydiagnostic application of operational criteria in studies of psychotic illness: Development and reliability of the OPCRIT system
64. Pharmacological characterization of U-101387, a dopamine D4 receptor selective antagonist
65. Novel polymorphisms in the upstream region of the human dopamine D4 receptor (DRD4) gene
66. Adult attention deficit hyperactivity disorder and the dopamine D4 receptor gene
67. Distribution of putative D4 dopamine receptors in postmortem striatum from patients with schizophrenia
68. Linkage studies between affective disorder and dopamine D2, D3, and D4 receptor gene loci in four Japanese pedigrees
69. D2 and D4 dopamine receptor polymorphisms and personality
70. Human dopamine D4 receptor gene: Frequent occurrence of a null allele and observation of homozygosity
71. Identification of a polymorphism in the promoter region of DRD4 associated with the human novelty seeking personality trait
72. Association between dopamine D4 receptor (D4DR) exon III polymorphism and novelty seeking in Japanese subjects
73. Analysis of the tyrosine hydroxylase and dopamine D4 receptor genes in a Croatian sample of bipolar I and unipolar patients
74. Dopamine D4 receptor gene: Novelty or nonsense?
75. Are there more than two syndromes in schizophrenia? A critique of the positive-negative dichotomy
76. An empirical analysis of latent structures underlying schizophrenic symptoms: A four-syndrome model
77. Association study between the dopamine D4 receptor gene and schizophrenia
78. Linkage strategies for genetically complex traits. I. Multilocus models
79. Dopamine Drd4 receptor polymorphism and attention deficit hyperactivity disorder
80. Mice lacking dopamine D4 receptors are supersensitive to ethanol, cocaine, and methamphetamine
81. Dopamine D4 receptor exon III alleles and variation of novelty seeking in alcoholics
82. Structural and functional correlates of subsyndromes in chronic schizophrenia
83. Dopamine D4 receptors elevated in schizofrenia
84. Dopamine D4 receptor variant, D4GLYCINE194, in Africans, but not in Caucasians: No association with schizophrenia
85. Tandem duplication polymorphism upstream of the dopamine d4 receptor gene (DRD4)
86. Identification of symptomatologic patterns common to major psychoses: Proposal for a phenotype definition
87. Dopamine receptor D4 gene is associated with delusional symptomatology in mood disorders
88. Dopamine receptor D4 gene is not associated with major psychoses
89. Genetic variants of dopamine receptor D4 and psychopathology
90. Failure to find linkage between a functional polymorphism in the dopamine D4 receptor gene and schizophrenia
91. Analysis of new D4 dopamine receptor (DRD4) coding region variants and TH microsatellite in the old order Amish family (OOA110)
92. Evidence that the dopamine D4 receptor is a susceptibility gene in attention deficit hyperactivity disorder
93. Dopamine D4 receptor variants in unrelated schizophrenic cases and controls
94. European collaborative project on affective disorders: Interactions between genetic and psychosocial vulnerability factors
95. Association between the dopamine D4 receptor (DRD4) exon III polymorphism and measures of novelty seeking in a German population
96. No association between novelty seeking and the type 4 dopamine receptor gene (DRD4) in two New Zealand samples
97. Dopamine D4 receptors and effects of guanine nucleotides on [3H]raclopride binding in postmortem caudate nucleus of subjects with schizophrenia or major depression
98. Association of the dopamine receptor D4 (DRD4) gene with a refined phenotype of attention deficit hyperactivity disorder (ADHD): A family-based approach
99. PNU-96415E, a potential antipsychotic agent with clozapine-like pharmacological properties
100. Psychopathological syndromes in the functional psychoses: Associations with course and outcome
101. Psychopathological syndromes and familial morbid risk of psychosis
102. Cloning of the gene for a human dopamine D4 receptor with high affinity for the antipsychotic clozapine
103. Multiple dopamine D4 receptor variants in the human population
104. No association between novelty seeking and dopamine D4 receptor (D4DR) exon III seven repeat alleles in Baltimore longitudinal study of aging participants
105. Association between different psychotic disorders and the DRD4 polymorphism, but no differences in the main ligand binding region of the DRD4 receptor protein compared to controls
106. Dopaminergic mechanisms in depression and mania
107. Is clozapine a mood stabilizer?